Applied Surface Science, Journal Year: 2024, Volume and Issue: 669, P. 160449 - 160449
Published: June 3, 2024
Language: Английский
Redox Biology, Journal Year: 2023, Volume and Issue: 68, P. 102967 - 102967
Published: Nov. 18, 2023
Oxidative stress occurs through an imbalance between the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms cells. The eye is particularly exposed to oxidative because its permanent exposure light due several structures having high metabolic activities. anterior part highly ultraviolet (UV) radiation possesses a complex system protect retina from UV radiation. posterior exhibits rates consumption leading subsequently production rate ROS. Furthermore, inflammation, aging, genetic factors, environmental pollution, are all elements promoting ROS impairing thereby representing risk factors stress. An abnormal redox status was shown be involved in pathophysiology various ocular diseases segment eye. In this review, we aim summarize provide updated understanding on pathogenesis common affecting surface, lens, retina, optic nerve. Moreover, discuss potential therapeutic approaches aimed at reducing context.
Language: Английский
Citations
83
Ophthalmology and Therapy, Journal Year: 2023, Volume and Issue: 12(2), P. 755 - 788
Published: Feb. 18, 2023
Exposure to blue light has seriously increased in our environment since the arrival of emitting diodes (LEDs) and, recent years, proliferation digital devices rich light. This raises some questions about its potential deleterious effects on eye health. The aim this narrative review is provide an update ocular and discuss efficiency methods protection prevention against light-induced injury. search relevant English articles was conducted PubMed, Medline, Google Scholar databases until December 2022. Blue exposure provokes photochemical reactions most tissues, particular cornea, lens, retina. In vitro vivo studies have shown that certain exposures (depending wavelength or intensity) can cause temporary permanent damage structures eye, especially However, currently, there no evidence screen use LEDs normal are human Regarding protection, currently a beneficial effect blocking lenses for diseases, age-related macular degeneration (AMD). humans, pigments (composed lutein zeaxanthin) represent natural by filtering light, be through intake from foods food supplements. These nutrients associated with lower risk AMD cataract. Antioxidants such as vitamins C, E, zinc might also contribute preventing oxidative stress. Currently, at domestic intensity levels retinotoxic eye. toxicity long-term cumulative dose-response unknown.
Language: Английский
Citations
75
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Age-related macular degeneration (AMD) is a prevalent degenerative disorder of the central retina, which holds global significance as fourth leading cause blindness. The condition characterized by multifaceted pathophysiology that involves aging, oxidative stress, inflammation, vascular dysfunction, and complement activation. complex interplay these factors contributes to initiation progression AMD. Current treatments primarily address choroidal neovascularization (CNV) in neovascular However, approval novel drug therapies for atrophic more gradual variant, known geographic atrophy (GA), has recently occurred. In light substantial impact AMD on affected individuals' quality life strain it places healthcare systems, there pressing need innovative medications. This paper aims provide an updated comprehensive overview advancements our understanding etiopathogenesis Special attention will be given influence aging altered redox status mitochondrial dynamics, cell death pathways, intricate between stress system, specifically context GA. Additionally, this review shed newly approved explore emerging alternative treatment strategies field. objective contribute ongoing dialogue surrounding AMD, offering insights into latest developments may pave way effective management intervention approaches.
Language: Английский
Citations
12
Progress in Retinal and Eye Research, Journal Year: 2022, Volume and Issue: 95, P. 101150 - 101150
Published: Dec. 6, 2022
Most studies evaluating cataract surgery focus on the primary outcome of early, central, best-corrected visual acuity. However, and intraocular lens (IOL) design have other secondary outcomes as well impacts various ocular tissues, function, quality life. Some these aspects are more difficult to quantify, or historically neglected, but might be extremely important patients. One development was addition blue-light filtering IOL design. Whether IOLs truly retinal protective qualities they were designed for is disputed, yet inadvertent desirable possibly detrimental influences being examined. Risk falls, driving accidents, injuries decrease following surgery, especially in elderly, importance which cannot overemphasized. Cataract formation contributes social isolation decreases cognitive stimulation elderly population, while extraction can reduce risk dementia decline. Diffractive multifocal extended depth-of-focus improve spectacle independence patient reported outcomes, positive negative dysphotopsia may persistent. Future directions such using enabling clear spectacle-free vision at all distances, intraoperative drug delivery systems show promising preliminary results. It seems inevitable that a higher will increase. We believe become relevant when considering new designs surgical techniques, fact benefit both patients surgeons.
Language: Английский
Citations
29
Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(2), P. 43 - 43
Published: Feb. 28, 2024
Purpose: RPE disruption with light exposures below or close to the American National Standards Institute (ANSI) photochemical maximum permissible exposure (MPE) have been observed, but these findings were limited two wavelengths. We extended measurements across visible spectrum. Methods: Retinal imaging fluorescence adaptive optics scanning ophthalmoscopy (FAOSLO) was used provide an in vivo measure of at a cellular level. The threshold retinal radiant (RREs) for (localized detectable change image) determined 460, 476, 488, 530, 543, 561, 594, 632, and 671 nm (uniform 0.5° square exposure) using multiples locations 4 macaques. Results: FAOSLO is sensitive detecting disruption. action spectrum dependence continuous wave (CW) field determined. It has shallower slope than current ANSI blue-light hazard MPE. At all wavelengths beyond 530 nm, There reciprocity irradiance duration 460 594 nm. Conclusions: measured Using this phototoxicity provided by FAOSLO, we find that thresholds are lower previously measured. wavelength our data considerably spectral traditional hazard, emphasizing need more caution increasing expected.
Language: Английский
Citations
5
Photonics, Journal Year: 2023, Volume and Issue: 10(5), P. 560 - 560
Published: May 11, 2023
The pandemic and lockdown caused by COVID-19 accelerated digitalization. Personal digital devices, emitting high-energy light, namely in the blue wavelength, have raised concerns about possible harmful effects on users’ eyes. Scientific research history has shown a relationship between exposure to light changes ocular structures. main goal of this review is examine frequent prolonged radiation from computers, tablets smartphones its consequences vision Bibliographic was carried out induced structures, cornea, crystalline lens retina based following scientific databases: BioOne Complete™; Google Scholar™; Paperity™; PubMed™; ScienceOpen™. most significant studies damage were selected reviewed. relevant bibliographic data analyzed summarized some gaps theme devices identified. experimental need acquire additional new suggested. hypothesis that continued use enriched with may interfere biological tissues lens, or not clarified available evidence. Therefore, are needed answer problem.
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4099 - 4099
Published: April 7, 2024
Age-related Macular Degeneration (AMD) is a multifactorial ocular pathology that destroys the photoreceptors of macula. Two forms are distinguished, dry and wet AMD, with different pathophysiological mechanisms. Although treatments were shown to be effective in they remain heavy burden for patients caregivers, resulting lack patient compliance. For no real treatment available Europe. It is, therefore, essential look new approaches. Recently, use long-chain very polyunsaturated fatty acids was identified as an interesting therapeutic alternative. Indeed, levels these acids, core components photoreceptors, significantly decreased AMD patients. To better understand this evaluate efficacy various molecules, vitro vivo models reproducing mechanisms both types developed. This article reviews anatomy physiological aging retina summarizes clinical aspects, potential strategies. In also presented. Finally, manuscript focuses on application omega-3 prevention AMD.
Language: Английский
Citations
4
Progress in Retinal and Eye Research, Journal Year: 2025, Volume and Issue: 105, P. 101326 - 101326
Published: Jan. 5, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 12, 2025
Introduction This study investigates the preferences of cataract patients in East China regarding intraocular lenses (IOLs). Methods A Discrete Choice Experiment (DCE) was conducted using a questionnaire that included various IOLs attributes. Participants made choices based on different combinations these attributes, and data were analyzed multinomial logit models (MNL) latent class analysis (LCA) to identify preference heterogeneity. Results total 200 (mean age 66.2 years, 58.5% female) participated study. The most influential factors IOL selection cost, followed by presbyopia correction, with for multifocal (trifocal bifocal), spherical aberration astigmatism correction. High cost higher probability adverse visual phenomena negatively affected preferences. inclusion blue-blocking functionality surgeon’s recommendation had minimal influence patient choice. LCA revealed three distinct groups: Class 1 (“Aberration Correction Seekers”) preferred aspheric IOLs, 2 (“Presbyopia Blue-Blocking Enthusiasts”) favored 3 (“Astigmatism Cost-Sensitive Patients”) toric IOLs. Multinomial logistic regression further showed male more likely choose while individuals education levels significantly less prefer Conclusion highlights significant heterogeneity Cost critical factor, Men exhibited sensitivity highly educated less. These findings underscore need personalized recommendations signal opportunities innovation customization industry.
Language: Английский
Citations
0
Current Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 5
Published: April 1, 2025
To evaluate the visual performance of a blue-light filter (BLF). The following parameters were assessed: glare disability (GD); chromatic contrast (CC); two-point light thresholds; and dysphotopsia symptoms (snowball spoke diameter). Twenty-five pseudophakic patients previously implanted with "UV-only" intraocular lens (IOL) tested using single-masked randomized cross-over design. In control condition, UV-only (matched to implant) was used. test BLF used (matching absorbance profile common IOL; Acrysof Natural Clareon; Alcon Research Ltd). intensity (expressed as log relative energy, LRE) broad-band xenon sky-blue background needed veil central grating target measure GD CC, respectively. diameter spokes/snowballs determined by measuring their lateral extent induced bright white point source. Two-point thresholds measured separation between two small relatively intense sources (Rayleigh criterion). resulted in improved CC (LRE 2.04 vs 1.83) = 2.46 2.27, p < 0.001). Snowballs (49 69 mm, 0.01) (139 171, 0.001) diameters also reduced condition. About 6% 10% more energy occlude stimulus for CC. Light spread technique about 26% less BLF. snowballs spokes 24% 19%. significantly function across variety indices.
Language: Английский
Citations
0