An ultra-sensitive dopamine measurement platform based on molecularly imprinted polymer-carbon hybrid nanomaterials for in vitro use DOI Creative Commons
Khadijeh Nekoueian,

Maedeh Akhoundian,

Niklas Wester

et al.

Electrochimica Acta, Journal Year: 2023, Volume and Issue: 445, P. 142029 - 142029

Published: Feb. 11, 2023

In the present study, we designed an ultrasensitive sensing platform for evaluation of physiologically relevant values basal dopamine (DA) in a culture medium as complex biological environment. The proposed was fabricated via integration molecular imprinting technology with carbon hybrid nanomaterials. Carbon nanofibers (CNFs) were grown by using plasma-enhanced chemical vapor deposition (PECVD) on tetrahedral amorphous (ta-C) thin films silicon wafers. prepared ta-C/CNFs platforms electrochemically coated DA-imprinted polypyrrole molecularly imprinted polymer (MIP) or "artificial receptors". three-dimensional MIP receptors able to determine trace DA phosphate-buffered saline solution (PBS) pH 7.4 (LOD = 5.43 nM) well absolute media such DMEM/F-12 39 nM), supplemented 15% horse serum and 2.5% fetal bovine 53.26 F-12 K cell 62.57 highly sensitivity free interference other coexisting biomolecules compounds. As all fabrication steps composite electrode are compatible common microsystem processes, results pave way integrating these ultra-sensitive electrodes microelectrode arrays (MEA) used human dopaminergic neurons studies vitro enable continuous measurement concentration real-time instance organoid studies.

Language: Английский

Electropolymerized polypyrrole silver nanocomposite coatings on porous Ti substrates with enhanced corrosion and antibacterial behavior for biomedical applications DOI Creative Commons
C. Garcı́a, V. Godinho, Clara Pérez‐Gonzàlez

et al.

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 29, P. 101433 - 101433

Published: March 8, 2023

This work proposes an innovative strategy that combines two well-known easy and economical preparation techniques: powder metallurgy based space-holder (SH) technique to provide porous biocompatible Ti substrates with balanced biomechanical behavior (for cortical bone tissue substitution) promoting ingrowth biocoating infiltration, electropolymerization coat these the polypyrrole–silver nanoparticles (PPy-AgNPs) composite conductive polymers improving its corrosion resistance, biocompatibility enhanced antibacterial activity. The deposited PPy-based coatings present a cauliflower-like structure well adhered substrates. macroporosity of rough inner pore surface SH are responsible for superior adhesion polymer comparing typical denser obtained by or forging. protection properties were investigated open circuit potential Anodic Polarization in PBS media simulate possible implant conditions, revealing improved resistance coatings. bioactivity was evaluated immersion tests, formation Hydroxyapatite after 90-day PBS. In both PPy PPy-AgNPs coatings, displacement polarization curves more noble potentials decrease current density, indicated coating's protective character is maintained activity assessed using Kirby–Bauer disk-diffusion method against Staphylococcus aureus (ATCC 25923). inhibition halo increased from 5.5 ± 0.4 mm bare substrate 8.2 0.6 PPy-coated 12.5 0.7 PPy-AgNPs-coated Ti. feature associated would significantly contribute success use implants envisaging substitution small damaged tissues example tumors.

Language: Английский

Citations

29
Conductive bacterial cellulose: From drug delivery to flexible electronics DOI
Artur Y. Prilepskii, V. A. Nikolaev,

Anastasiia Klaving

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 313, P. 120850 - 120850

Published: March 29, 2023

Language: Английский

Citations

29
Conjugated polymer-based composite scaffolds for tissue engineering and regenerative medicine DOI Creative Commons
Nazila Biglari, Ehsan Nazarzadeh Zare‬

Alexandria Engineering Journal, Journal Year: 2023, Volume and Issue: 87, P. 277 - 299

Published: Dec. 28, 2023

Conjugated polymers such as polypyrrole, polyaniline, and polythiophene have developed capable candidates for scaffold fabrication due to their electrical conductivity, tunable surface properties, ability deliver bioactive molecules. When blended with other biomaterials nanoparticles enables the formation of composites that leverage advantages both components. The main focus areas review include use conjugated polymer-based (CPCs) tissue engineering e.g., neural, cardiac, bone, skin. Within each section, specific examples are provided polymer-biomolecule composite systems been explored along a discussion composition, fabrication, performance supporting cell growth regeneration. Finally, current challenges future perspectives discussed in applying CPCs toward clinically relevant tissues organs. Overall, this comprehensive covers fundamental design considerations developing polymer scaffolds emerging applications engineering.

Language: Английский

Citations

27
Highly Specialized Textiles with Antimicrobial Functionality—Advances and Challenges DOI Creative Commons
Fulga Tanasă, Carmen‐Alice Teacă,

M Nechifor

et al.

Textiles, Journal Year: 2023, Volume and Issue: 3(2), P. 219 - 245

Published: May 18, 2023

Textiles with antimicrobial functionality have been intensively and extensively investigated in the recent decades, mostly because they are present everyday life various applications: medicine healthcare, sportswear, clothing footwear, furniture upholstery, air water purification systems, food packaging etc. Their ability to kill or limit growth of microbial population a certain context defines their activity against bacteria, fungi, viruses, even initial formation biofilm prior microorganisms’ proliferation. Various classes antimicrobials employed for these highly specialized textiles, namely, organic synthetic reagents polymers, metals metal oxides (micro- nanoparticles), natural naturally derived compounds, range applications critically assessed. At same time, different modern processing techniques reviewed relation applications. This paper focuses on some advances challenges field textiles given practical importance as it appears from most reports literature.

Language: Английский

Citations

23
Ternary inulin hydrogel with long-term intestinal retention for simultaneously reversing IBD and its fibrotic complication DOI Creative Commons

Xiangjing Cao,

Tao Shi, Weitao Wang

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 28, 2024

Excessive accumulation of reactive oxygen and nitrogen species (RONS) dysbiosis intestinal microbiota are pivotal symptoms for inflammatory bowel disease (IBD) its associated complications, such as fibrosis. This research introduces a probiotic inulin hydrogel loaded with polypyrrole (PPy) nanozymes antifibrotic drug pirfenidone (PFD) (PPy/PFD@Inulin gel) designed the concurrent amelioration IBD fibrotic complication. Upon oral administration, gel matrix could extend gastrointestinal residence time PPy PFD, facilitating efficient reduction pro-inflammatory cytokine levels enhancement epithelial barrier repair well suppression fibrosis through sustained RONS scavenging, modulation gut attenuation TGF-β/Smad signaling pathway to inhibit fibroblast proliferation. Notably, PPy/PFD@Inulin demonstrated significant prophylactic therapeutic efficacy in acute chronic colitis induced by dextran sodium sulfate (DSS) mouse models. Thus, engineered ternary offered pioneered paradigm simultaneous reversal fibrosis, single regimen.

Language: Английский

Citations

13
Insights into properties, synthesis and emerging applications of polypyrrole-based composites, and future prospective: A review DOI Creative Commons
Yuvika Sood,

Kartika Singh,

Harish Mudila

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33643 - e33643

Published: June 27, 2024

Recent advancements in polymer science and engineering underscore the importance of creating sophisticated soft materials characterized by well-defined structures adaptable properties to meet demands emerging applications. The primary objective polymeric composite technology is enhance functional utility for high-end purposes. Both inherent qualities intricacies synthesis process play pivotal roles advancing their expanding potential Polypyrrole (PPy)-based composites, owing distinctive properties, hold great appeal a variety Despite limitations PPy its pure form, these constraints can be effectively overcome through hybridization with other materials. This comprehensive review thoroughly explores existing literature on PPy-based providing in-depth insights into synthesis, Special attention given advantages intrinsically conducting polymers (ICPs) comparison ICPs. impact doping anions, additives, oxidants also examined. By delving aspects, this overview aims inspire researchers delve realm encouraging them explore new avenues flexible

Language: Английский

Citations

9
Green Synthesis of Silver Nanoparticles Using Cyto-compatible Polymer Derivative of Tara Gum for Gold (III) ion Detection in Water Samples DOI
Titilope John Jayeoye, Sudarshan Singh, Fredrick Nwude Eze

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Language: Английский

Citations

9
Development of Flexible Nanocomposites Based on Poly(ε-caprolactone) for Tissue Engineering Application: The Contributing Role of Poly(glycerol succinic acid) and Polypyrrole DOI
Aliakbar Jafari, Vafa Fakhri,

Soosan Kamrani

et al.

European Polymer Journal, Journal Year: 2022, Volume and Issue: 164, P. 110984 - 110984

Published: Jan. 4, 2022

Language: Английский

Citations

38
Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole DOI
Aliakbar Jafari,

Hadis Mirzaei,

Mir Alireza Shafiei

et al.

Polymers for Advanced Technologies, Journal Year: 2022, Volume and Issue: 33(5), P. 1427 - 1441

Published: Jan. 11, 2022

Abstract Biocompatible and electrically conductive porous scaffolds with a desirable hydrophilicity degradation rate suitable mechanical performance are highly favorable for tissue engineering regenerative medicine applications. In this study, we fabricated three‐dimensional (3D) bioscaffolds from poly(ε‐caprolactone) polylactic acid containing different concentrations of zirconia nanoparticles (n‐ZrO 2 ) through freeze‐drying technique. Afterward, the surface was coated an layer in situ polymerization polypyrrole (PPy) on samples. Bioscaffolds exhibited range properties electrical conductivity, meeting required performances conductivity broad Coating PPy resulted significantly higher faster biodegradation rate, as well noticeable enhancement vitro cell attachment, proliferation, viability. Our findings indicated that simultaneous presence n‐ZrO system presents synergistic effect overall introduces 3D promising candidates

Language: Английский

Citations

31
Photoactive polymers-decorated Cu-Al layered double hydroxide hexagonal architectures: A potential non-viral vector for photothermal therapy and co-delivery of DOX/pCRISPR DOI
Milad Ashrafizadeh, Ehsan Nazarzadeh Zare‬, Filippo Rossi

et al.

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 448, P. 137747 - 137747

Published: June 22, 2022

Language: Английский

Citations

31