Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(9), P. 5505 - 5616

Published: April 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Language: Английский

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Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)

Published: Sept. 6, 2021

Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration (IVDD) and achieves its effects by regulating metabolic disorders, the microenvironment cell homeostasis with sustained release of microRNAs, proteins, transcription factors. However, rapid clearance disruption exosomes are two major challenges application exosome in IVDD. Herein, thermosensitive acellular extracellular matrix (ECM) hydrogel coupled adipose-derived mesenchymal stem (ADSC) (dECM@exo) that inherits superior properties nucleus pulposus tissue ADSCs was fabricated to ameliorate This dECM@exo system can provide not only situ gelation replenish ECM leakage cells (NPCs) but also an environment growth NPCs. In addition, ADSC-derived from this regulates synthesis degradation metalloproteinases (MMPs) inhibits pyroptosis mitigating inflammatory response vitro. Animal results demonstrated maintained early IVD ameliorated functional serve as powerful platform drug delivery biotherapy alternative

Language: Английский

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Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12567 - 12603

Published: Aug. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Language: Английский

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Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

Biomolecules, Journal Year: 2022, Volume and Issue: 12(6), P. 784 - 784

Published: June 4, 2022

Cancer is one of the main causes death worldwide. To date, and despite advances in conventional treatment options, therapy cancer still far from optimal due to non-specific systemic biodistribution antitumor agents. The inadequate drug concentrations at tumor site led an increased incidence multiple resistance appearance many severe undesirable side effects. Nanotechnology, through development nanoscale-based pharmaceuticals, has emerged provide new innovative drugs overcome these limitations. In this review, we overview approved nanomedicine for rationale behind their designs applications. We also highlight approaches that are currently under investigation perspectives challenges nanopharmaceuticals, focusing on microenvironment disseminate cells as most attractive effective strategies treatments.

Language: Английский

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Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 272, P. 118491 - 118491

Published: July 27, 2021

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from widespread emergence drug resistance. Although doxorubicin (DOX) induces cell cycle arrest DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) been extensively utilized synthesizing nanoparticles as it interacts with CD44 expressed on surface cells. Cancer cells can take up HA-modified through receptor-mediated endocytosis. Various types nanostructures such carbon nanomaterials, lipid polymeric nanocarriers have modified HA enhance delivery acid-based advanced materials provide a platform co-delivery genes drugs along efficacy overcome chemoresistance. In present review, potential methods application are discussed.

Language: Английский

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Dissecting Tumor Growth: The Role of Cancer Stem Cells in Drug Resistance and Recurrence

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 976 - 976

Published: Feb. 15, 2022

Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal cells, i.e., self-renewal differentiation potential, suggesting they can drive progression. Consequently, targeting to prevent tumor growth or regrowth might offer chance lead the fight against cancer. create their niche, specific area within tissue unique microenvironment sustains vital functions. Interactions between niches play critical role regulating CSCs' tumorigenesis. Differences observed frequency CSCs, due phenotypic plasticity many remain challenge therapeutics, since modulate transcriptional activities into more stem-like state protect themselves from destruction. This represents an essential step future therapeutic approaches. Regarding self-renewal, are modulated by same molecular pathways found such as Wnt/β-catenin signaling, Notch Hedgehog signaling. Another key characteristic resistance standard chemotherapy radiotherapy treatments, capacity rest quiescent state. review will analyze primary mechanisms involved CSC tumorigenesis, particular attention roles progression benign malignant diseases; examine perspectives on identification new markers better control well dissecting process.

Language: Английский

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Cancer stem cells: advances in knowledge and implications for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 5, 2024

Abstract Cancer stem cells (CSCs), a small subset of in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, maintain tumor heterogeneity. continues be significant global disease burden. In the past, surgery, radiotherapy, chemotherapy were main cancer treatments. The technology treatments develop advance, emergence targeted therapy, immunotherapy provides more options for patients certain extent. However, limitations efficacy treatment resistance still inevitable. Our review begins with brief introduction historical discoveries, original hypotheses, pathways regulate CSCs, such as WNT/β-Catenin, hedgehog, Notch, NF-κB, JAK/STAT, TGF-β, PI3K/AKT, PPAR pathway, their crosstalk. We focus on role CSCs various therapeutic outcomes resistance, including how affect content alteration related molecules, CSCs-mediated clinical value targeting refractory, progressed or advanced tumors. summary, efficacy, method is difficult determine. Clarifying regulatory mechanisms biomarkers currently mainstream idea.

Language: Английский

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Dysregulated Signalling Pathways Driving Anticancer Drug Resistance

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12222 - 12222

Published: July 30, 2023

One of the leading causes death worldwide, in both men and women, is cancer. Despite significant development therapeutic strategies, inevitable emergence drug resistance limits success impedes curative outcome. Intrinsic acquired are common mechanisms responsible for cancer relapse. Several factors crucially regulate tumourigenesis resistance, including physical barriers, tumour microenvironment (TME), heterogeneity, genetic epigenetic alterations, immune system, burden, growth kinetics undruggable targets. Moreover, transforming factor-beta (TGF-β), Notch, epidermal factor receptor (EGFR), integrin-extracellular matrix (ECM), nuclear kappa-light-chain-enhancer activated B cells (NF-κB), phosphoinositol-3-kinase/protein kinase B/mammalian target rapamycin (PI3K/Akt/mTOR), wingless-related integration site (Wnt/β-catenin), Janus kinase/signal transducers activators transcription (JAK/STAT) RAS/RAF/mitogen-activated protein (MAPK) signalling pathways some key players that have a pivotal role mechanisms. To guide future treatments improve results, deeper comprehension necessary. This review covers intrinsic gives comprehensive overview recent research on enable to bypass barriers put up by treatments, and, like “satellite navigation”, find alternative routes which carry their “journey” progression.

Language: Английский

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Disulfidptosis-related lncRNA signatures assess immune microenvironment and drug sensitivity in hepatocellular carcinoma

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 169, P. 107930 - 107930

Published: Jan. 4, 2024

Language: Английский

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Research progress in tumor angiogenesis and drug resistance in breast cancer

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: June 25, 2024

Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from angiogenesis plays critical role the development of resistance to breast cancer treatments,

Language: Английский

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