Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: March 28, 2024
Abstract
Targeted
drug
delivery
and
the
reduction
of
off‐target
effects
are
crucial
for
promising
clinical
application
nucleic
acid
drugs.
To
address
this
challenge,
a
new
approach
treating
osteoarthritis
(OA)
that
accurately
delivers
antisense
oligonucleotides
(ASO)
targeting
matrix
metalloproteinase‐13
(ASO‐MMP13)
to
chondrocytes,
is
developed.
Small
extracellular
vesicles
(exos)
ligated
with
chondrocyte
affinity
peptide
(CAP)
using
Sortase
A
subsequently
incubated
cholesterol‐modified
ASO‐MMP13
construct
chondrocyte‐targeted
exo
(CAP‐exoASO).
Compared
exos
without
CAP
(ExoASO),
CAP‐exoASOs
attenuate
IL‐1β‐induced
damage
prolong
retention
time
in
joint
distribution
major
organs
following
intra‐articular
injection.
Notably,
decrease
MMP13
expression
(
P
<
0.001)
upregulate
COL2A1
=
0.006),
resulting
reorganization
cartilage
alleviation
progression
OA
model.
Furthermore,
Osteoarthritis
Research
Society
International
(OARSI)
score
articular
tissues
treated
CAP‐exoASO
comparable
healthy
rats
0.148).
mechanistic
study
demonstrates
may
reduce
inflammation
by
suppressing
IL‐17
TNF
signaling
pathways.
Based
on
targeted
effect,
successfully
accomplish
repair
have
considerable
potential
development
as
therapeutic
modality
satisfactory
therapy.
Cancer Nanotechnology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 17, 2025
Emphasizing
the
significance
of
cancer-associated
fibroblasts
(CAFs),
non-malignant
yet
pivotal
players
within
tumor
microenvironment
(TME),
this
review
illuminates
role
inflammatory
subtype
(iCAF)
as
catalysts
in
cancer
proliferation,
metastasis,
and
therapeutic
resistance.
Given
their
paramount
importance,
targeting
CAFs
emerges
a
robust
strategy
evolving
landscape
immunotherapy.
Nanomaterials,
distinguished
by
unique
features
malleability,
hold
considerable
promise
biomedicine,
especially
precision-oriented
domain
therapy.
Their
aptitude
for
modulating
immune
responses,
amplifying
drug
efficacy
through
precise
delivery,
discerningly
focusing
on
cells
TME
situates
nanomaterials
formidable
tools
to
transcend
boundaries
set
conventional
treatments.
This
scrutinizes
convoluted
interplay
among
CAFs,
cells,
TME.
It
further
showcases
widely
utilized
management.
We
underscore
potential
nanoscale
delivery
systems
directed
at
underscoring
transformative
power
revolutionizing
therapies,
enhancing
precision,
culminating
improved
patient
outcomes.
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
11(8), P. 2585 - 2604
Published: April 29, 2021
Invasive
fungal
infections
(IFIs)
represent
a
growing
public
concern
for
clinicians
to
manage
in
many
medical
settings,
with
substantial
associated
morbidities
and
mortalities.
Among
current
therapeutic
options
the
treatment
of
IFIs,
amphotericin
B
(AmB)
is
most
frequently
used
drug.
AmB
considered
as
first-line
drug
clinic
that
has
strong
antifungal
activity
less
resistance.
In
this
review,
we
summarized
promising
research
efforts
on
nanocarriers
delivery
highlighted
their
efficacy
safety
treating
IFIs.
We
have
also
discussed
mechanism
actions
AmB,
rationale
recent
advances
formulating
clinical
use.
Finally,
review
discusses
some
practical
considerations
provides
recommendations
future
studies
applying
combating
Nanomaterials,
Journal Year:
2021,
Volume and Issue:
11(7), P. 1755 - 1755
Published: July 5, 2021
Cancer
stem
cells
(CSCs)
are
a
subpopulation
of
that
can
initiate,
self-renew,
and
sustain
tumor
growth.
CSCs
responsible
for
metastasis,
recurrence,
drug
resistance
in
cancer
therapy.
reside
within
niche
maintained
by
multiple
unique
factors
the
microenvironment.
These
include
hypoxia,
excessive
levels
angiogenesis,
change
mitochondrial
activity
from
aerobic
aspiration
to
glycolysis,
an
upregulated
expression
CSC
biomarkers
cell
signaling,
elevated
synthesis
cytochromes
P450
family
enzymes
clearance.
Antibodies
ligands
targeting
maintain
utilized
delivery
anticancer
therapeutics
CSCs.
In
this
regard,
nanomaterials,
specifically
nanoparticles
(NPs),
extremely
useful
as
carriers
agents
This
review
covers
biology
advances
design
NPs
carrier
drugs
cells.
includes
development
synthetic
natural
polymeric
NPs,
lipid
inorganic
self-assembling
protein
antibody-drug
conjugates,
extracellular
nanovesicles
targeting.
Materials Today Bio,
Journal Year:
2022,
Volume and Issue:
16, P. 100394 - 100394
Published: Aug. 13, 2022
Sustained-release
drug-loaded
microspheres
provide
a
long-acting
sustained
release,
with
targeted
and
other
effects.
There
are
many
types
of
sustained-release
drug
various
preparation
methods,
they
easy
to
operate.
For
these
reasons,
have
attracted
widespread
interest
widely
used
in
tissue
engineering
fields.
In
this
paper,
we
systematic
review
the
application
engineering.
First,
introduce
new
type
delivery
system
(sustained-release
carriers),
describe
microspheres,
summarize
characteristics
different
microspheres.
Second,
methods
materials
required
for
preparing
Third,
applications
summarized.
Finally,
shortcomings
discuss
future
prospects
development
The
purpose
paper
was
further
understanding
personnel
engaged
related
fields
inspiration
ideas
studies
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 7, 2022
Cerebral
infarction/ischemia-reperfusion
injury
is
currently
the
disease
with
highest
mortality
and
disability
rate
of
cardiovascular
disease.
Current
studies
have
shown
that
nerve
cells
die
ischemia
several
hours
after
ischemic
stroke,
which
activates
innate
immune
response
in
brain,
promotes
production
neurotoxic
substances
such
as
inflammatory
cytokines,
chemokines,
reactive
oxygen
species
−
nitrogen
oxide,
mediates
destruction
blood-brain
barrier
occurrence
a
series
cascade
reactions.
Meanwhile,
expression
adhesion
molecules
cerebral
vascular
endothelial
increased,
polymorphonuclear
neutrophils,
lymphocytes
mononuclear
macrophages
passed
through
entered
brain
tissue.
These
recognize
antigens
exposed
by
central
nervous
system
activate
adaptive
responses,
further
mediate
secondary
neuronal
damage,
aggravating
neurological
deficits.
In
order
to
reduce
above-mentioned
body
induces
peripheral
immunosuppressive
responses
negative
feedback,
increases
incidence
post-stroke
infection.
This
process
accompanied
changes
status
tissue
local
systemic
systems.
A
growing
number
implicate
noncoding
RNAs
(ncRNAs)
novel
epigenetic
regulatory
elements
dysfunction
various
cell
subsets
neurovascular
unit
injury.
particular,
recent
revealed
advances
ncRNA
biology
greatly
expand
understanding
regulation
inflammation
Identification
aberrant
patterns
associated
biological
effects
ncRNAs
patients
their
potential
biomarkers
therapeutic
targets
for
Therefore,
this
review
systematically
presents
on
involvement
neuroimmune
cascades,
elucidates
functions
mechanisms
infarction/ischemia-reperfusion-related
ncRNAs,
providing
new
opportunities
discovery
targeted
therapy.
Furthermore,
introduces
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)-Display
possible
transformative
tool
studying
lncRNAs.
future,
expected
be
used
target
diagnosing
injury,
judging
its
prognosis
treatment,
thereby
significantly
improving
patients.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 5167 - 5167
Published: May 5, 2022
Cervical
cancer
(CC)
is
the
fourth
most
common
type
of
gynecological
malignancy
affecting
females
worldwide.
Most
CC
cases
are
linked
to
infection
with
high-risk
human
papillomaviruses
(HPV).
There
has
been
a
significant
decrease
in
incidence
and
death
rate
due
effective
cervical
Pap
smear
screening
administration
vaccines.
However,
this
not
equally
available
throughout
different
societies.
The
prognosis
patients
advanced
or
recurrent
particularly
poor,
one-year
relative
survival
maximum
20%.
Increasing
evidence
suggests
that
stem
cells
(CSCs)
may
play
an
important
role
tumorigenesis,
metastasis,
relapse,
chemo/radio-resistance,
thus
representing
potential
targets
for
better
therapeutic
outcome.
CSCs
small
subpopulation
tumor
self-renewing
ability,
which
can
differentiate
into
heterogeneous
cell
types,
creating
progeny
constituting
bulk
tumors.
Since
(CCSC)
difficult
identify,
led
search
markers
(e.g.,
ABCG2,
ITGA6
(CD49f),
PROM1
(CD133),
KRT17
(CK17),
MSI1,
POU5F1
(OCT4),
SOX2).
Promising
strategies
targeting
CSC-signaling
pathways
CSC
niche
currently
under
development.
Here,
we
provide
overview
CCSCs,
describing
phenotypes
CCSCs
management
CC.
Journal of Controlled Release,
Journal Year:
2023,
Volume and Issue:
363, P. 57 - 83
Published: Sept. 23, 2023
There
is
increasing
evidence
that
malignant
tumors
are
initiated
and
maintained
by
a
sub-population
of
tumor
cells
have
similar
biological
properties
to
normal
adult
stem
cells.
This
very
small
population
Cancer
Stem
Cells
(CSC)
comprises
initiating
responsible
for
cancer
recurrence,
drug
resistance
metastasis.
Conventional
treatments
such
as
chemotherapy,
radiotherapy
surgery,
in
addition
being
potentially
toxic
non-specific,
may
paradoxically
increase
the
population,
spread
survival
CSCs.
Next-generation
sequencing
omics
technologies
our
understanding
pathways
factors
involved
development
CSCs,
can
help
discover
new
therapeutic
targets
against
In
addition,
recent
advances
nanomedicine
provided
hope
optimal
specific
therapies
eradicate
Moreover,
use
artificial
intelligence
nano-informatics
elucidate
targets,
design
drugs
nanoparticles
(NPs)
deal
with
this
review,
we
first
summarize
CSCs
describe
signaling
molecular
characteristics
emergence
Also,
location
within
effect
host
on
creation
maintenance
discussed.
Newly
discovered
stemness
some
novel
compounds
combat
highlighted.
The
optimum
anti-CSC
NPs,
including
blood
circulation
stability,
accumulation
penetration,
cellular
internalization,
release,
endosomal
escape,
aptamers
designed
targeting
covered.
Finally,
smart
NPs
theranostic
purposes
overcome
