Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130477 - 130477
Published: Jan. 1, 2025
Language: Английский
Smart Medicine, Journal Year: 2022, Volume and Issue: 1(1)
Published: Dec. 1, 2022
Osteoarthritis (OA) is a common disease that endangers millions of middle-aged and elderly people worldwide. Researchers from different fields have made great efforts achieved remarkable progress in the pathogenesis treatment OA. However, there still no cure for In this review, we discuss OA summarize current clinical therapies. Moreover, introduce various natural synthetic biomaterials drug release, cartilage transplantation, joint lubricant during treatment. We also present our perspectives insights on future. hope review will foster communication collaboration among biological, clinical, biomaterial researchers, paving way therapeutic breakthroughs.
Language: Английский
Citations
85
Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)
Published: Jan. 3, 2023
Plastic surgery is a discipline that uses surgical methods or tissue transplantation to repair, reconstruct and beautify the defects deformities of human tissues organs. Three-dimensional (3D) bioprinting has gained widespread attention because it enables fine customization implants in patient's area preoperatively while avoiding some adverse reactions complications traditional approaches. In this paper, we review recent research advances application 3D plastic surgery. We first introduce printing process basic principles technology, revealing advantages disadvantages different technologies. Then, describe currently available materials, dissect rationale for special dynamic (4D bioprinting) achieved by varying combination strategy materials. Later, focus on viable clinical applications effects Finally, summarize discuss challenges prospects believe can contribute further development provide lessons related research.
Language: Английский
Citations
67
European Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 194, P. 106704 - 106704
Published: Jan. 14, 2024
Microparticles have unique benefits in the formulation of multiparticulate and multi-unit type pharmaceutical dosage forms allowing improved drug safety efficacy with favorable pharmacokinetics patient centricity. On other hand, above advantages are served by high well reproducible quality attributes medicinal product where even flexible design controlled processability offer success as possible longer life-cycle for manufacturers. Moreover, specific demands patients can be taken into account, including simplified dosing regimens, dosage, combinations, palatability, ease swallowing. In more than 70 years since first modified-release appeared on market, many new formulations been marketed publications literature. More newer technologies excipients become available producing tailor-made particles micrometer dimensions beyond. All these contributed to fact that sub-units (e.g. minitablets, pellets, microspheres) make up a system vary widely composition properties. Some units mucoadhesive properties others float contribute suitable release profile designed formula whole. Nowadays, there some which able active substance several months (3 or 6 depending treatment). this review, latest developments used long time presented, innovative solutions such applicability 3D printing produce subunits systems. Furthermore, diversity systems, different routes administration also touching ones capable carrying relevant, commercially multiparticle-based medical devices. The versatility size from 1 µm multiplicity promise solid foundation future applications form development.
Language: Английский
Citations
20
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(14), P. 17532 - 17542
Published: March 28, 2023
Androgenetic alopecia (AGA) is the most common type of progressive hair loss in both men and women that severely reduces life quality affects patients' self-esteem. Due to shortcomings traditional therapeutic formulations (e.g., topical minoxidil oral finasteride), such as low bioavailability, frequent dosing, significant side effects, there an urgent need develop a safe effective strategy for AGA treatment. Here, we report water-soluble microneedle (MN) patch integrated with biodegradable (MXD)-loaded microspheres long-acting treatment reduced administration frequency improved patient compliance. When pierces skin, MNs rapidly dissolve deliver MXD-encapsulated polylactic-co-glycolic acid (PLGA) into which, subsequently act drug reservoirs sustained release therapeutics over 2 weeks. Additionally, application MN provided mechanical stimulation on mouse which was also helpful regrowth. Compared MXD solutions have been commercialized market require daily application, contains much lower amount shows similar or superior regeneration effect mice while only requiring monthly weekly administration. These encouraging results suggest simple, safe, clinics.
Language: Английский
Citations
40
Applied Materials Today, Journal Year: 2023, Volume and Issue: 36, P. 102036 - 102036
Published: Dec. 22, 2023
Language: Английский
Citations
27
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116024 - 116024
Published: Dec. 19, 2023
Bioactive macromolecular drugs known as Growth Factors (GFs), approved by the Food and Drug Administration (FDA), have found successful application in clinical practice. They hold significant promise for addressing peripheral nerve injuries (PNIs). Peripheral guidance conduits (NGCs) loaded with GFs, context of tissue engineering, can ensure sustained efficient release these bioactive compounds. This, turn, maintains a stable, long-term, effective GF concentration essential treating damaged nerves. regeneration is complex process that entails secretion various GFs. Following PNI, GFs play pivotal role promoting cell growth survival, axon myelin sheath regeneration, differentiation, angiogenesis. also regulate regenerative microenvironment, stimulate plasticity changes post-nerve injury, and, consequently, expedite structure function repair. Both exogenous endogenous including NGF, BDNF, NT-3, GDNF, IGF-1, bFGF, VEGF, been successfully onto NGCs using techniques like physical adsorption, blend doping, chemical covalent binding, engineered transfection. These approaches effectively promoted repair Numerous studies demonstrated similar functional therapeutic outcomes compared to autologous transplantation. This evidence underscores substantial potential domain In this article, we provide an overview drug delivery systems utilizing NGCs. Looking ahead, commercial materials facilitate nerves maintain functionality distant target organs through
Language: Английский
Citations
23
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170364 - 170364
Published: Feb. 1, 2024
Language: Английский
Citations
10
Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35014 - e35014
Published: July 22, 2024
Language: Английский
Citations
10
Asian Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Hyaluronic acid (HA) is a natural glycosaminoglycan found in the human body, particularly extracellular matrix of body fluids and tissues. It plays critical role cellular processes living organisms by maintaining tissue hydration, cell proliferation, differentiation, inflammatory response. HA exhibits significant biological activity skin care, aesthetic anti-aging, medical orthopedic repair, gynecological cancer monitoring, other pathological conditions. Due to its exceptional biocompatibility, biodegradability, lack toxicity, non-immunogenicity, capacity bond with substances, various HA-based biomedical products like hydrogels, microneedles, microspheres have been developed. These innovations also applied health fields, such as bone regeneration, gels for fillers, gynecology-related treatment, utilizing drug delivery pathway. The interest increasing due their functions. Therefore, this review aimed summarize properties focus on applications engineering healthcare, has some practical complexes materials, aesthetics, gynecology. Through review, we seek offer theoretical research assistance development bioproducts healthcare domain provide innovative insights health.
Language: Английский
Citations
10
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 665, P. 124687 - 124687
Published: Sept. 10, 2024
Language: Английский
Citations
9