Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(11), P. 4391 - 4416
Published: May 20, 2023
Owing
to
the
inherent
shortcomings
of
traditional
therapeutic
drugs
in
terms
inadequate
efficacy
and
toxicity
clinical
treatment,
nanomedicine
designs
have
received
widespread
attention
with
significantly
improved
reduced
non-target
side
effects.
Nanomedicines
hold
tremendous
theranostic
potential
for
treating,
monitoring,
diagnosing,
controlling
various
diseases
are
attracting
an
unfathomable
amount
input
research
resources.
Against
backdrop
exponentially
growing
number
publications,
it
is
imperative
help
audience
get
a
panorama
image
activities
field
nanomedicines.
Herein,
this
review
elaborates
on
development
trends
nanomedicines,
emerging
nanocarriers,
vivo
fate
safety
their
extensive
applications.
Moreover,
challenges
obstacles
hindering
translation
nanomedicines
also
discussed.
The
elaboration
aspects
may
enlighten
readers
set
route
future
endeavors.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
167, P. 115597 - 115597
Published: Sept. 30, 2023
The
field
of
nanotechnology
has
revolutionised
global
attempts
to
prevent,
treat,
and
eradicate
infectious
diseases
in
the
foreseen
future.
Nanovaccines
have
proven
be
a
valuable
pawn
this
novel
technology.
are
made
up
nanoparticles
that
associated
with
or
prepared
components
can
stimulate
host's
immune
system.
In
addition
their
delivery
capabilities,
nanocarriers
been
demonstrated
possess
intrinsic
adjuvant
properties,
working
as
cell
stimulators.
Thus,
nanovaccines
potential
promote
rapid
well
long-lasting
humoral
cellular
immunity.
several
possible
benefits,
including
site-specific
antigen
delivery,
increased
bioavailability,
diminished
adverse
effect
profile.
To
avail
these
nanoparticle-based
vaccines
being
developed,
virus-like
particles,
liposomes,
polymeric
nanoparticles,
nanogels,
lipid
emulsion
vaccines,
exomes,
inorganic
nanoparticles.
Inspired
by
distinctive
researchers
on
development
for
variety
applications,
such
cancer
immunotherapy
diseases.
Although
few
challenges
still
need
overcome,
modulation
nanoparticle
pharmacokinetics
avoid
elimination
from
bloodstream
reticuloendothelial
system,
future
prospects
technology
also
assuring,
multiple
options
personalised
needle-free
formulations,
combination
promising
candidates.
Frontiers in Medicine,
Journal Year:
2023,
Volume and Issue:
10
Published: Nov. 21, 2023
Sepsis
is
a
systemic
inflammatory
disease
caused
by
severe
infections
that
involves
multiple
organs,
among
which
the
lung
most
susceptible,
leaving
patients
highly
vulnerable
to
acute
injury
(ALI).
Refractory
hypoxemia
and
respiratory
distress
are
classic
clinical
symptoms
of
ALI
sepsis,
has
mortality
rate
40%.
Despite
extensive
research
on
mechanisms
exact
pathological
process
not
fully
understood.
This
article
reviews
advances
in
pathogenesis
sepsis
focusing
treatment
regimens
adopted
practice
for
corresponding
molecular
mechanisms.
review
can
only
contribute
theories
but
also
recommend
new
strategies
related
injuries.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 25, 2024
Abstract
Sepsis,
a
prevalent
critical
condition
in
clinics,
continues
to
be
the
leading
cause
of
death
from
infections
and
global
healthcare
issue.
Among
organs
susceptible
harmful
effects
sepsis,
lungs
are
notably
most
frequently
affected.
Consequently,
patients
with
sepsis
predisposed
developing
acute
lung
injury
(ALI),
severe
cases,
respiratory
distress
syndrome
(ARDS).
Nevertheless,
precise
mechanisms
associated
onset
ALI/ARDS
remain
elusive.
In
recent
years,
there
has
been
growing
emphasis
on
role
endothelial
cells
(ECs),
cell
type
integral
barrier
function,
their
interactions
various
stromal
sepsis-induced
ALI/ARDS.
this
comprehensive
review,
we
summarize
involvement
intricate
interplay
immune
cells,
including
pulmonary
epithelial
fibroblasts,
pathogenesis
ALI/ARDS,
particular
placed
discussing
several
pivotal
pathways
implicated
process.
Furthermore,
discuss
potential
therapeutic
interventions
for
modulating
functions
relevant
present
strategy
managing
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
13(10), P. 4105 - 4126
Published: Nov. 30, 2022
Messenger
RNA
(mRNA)
is
the
template
for
protein
biosynthesis
and
emerging
as
an
essential
active
molecule
to
combat
various
diseases,
including
viral
infection
cancer.
Especially,
mRNA-based
vaccines,
a
new
type
of
vaccine,
have
played
leading
role
in
fighting
against
current
global
pandemic
COVID-19.
However,
inherent
drawbacks,
large
size,
negative
charge,
instability,
hinder
its
use
therapeutic
agent.
Lipid
carriers
are
distinguishable
promising
vehicles
mRNA
delivery,
owning
capacity
encapsulate
deliver
negatively
charged
drugs
targeted
tissues
release
cargoes
at
desired
time.
Here,
we
first
summarized
structure
properties
different
lipid
carriers,
such
liposomes,
liposome-like
nanoparticles,
solid
lipid-polymer
hybrid
nanoemulsions,
exosomes
lipoprotein
particles,
their
applications
delivering
mRNA.
Then,
development
lipid-based
formulations
vaccine
delivery
systems
was
discussed
highlighted.
Recent
advancements
COVID-19
were
emphasized.
Finally,
described
our
future
vision
perspectives
this
field.