Study of tumor necrosis factor receptor in the inflammatory bowel disease

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(18), P. 2733 - 2746

Published: May 10, 2023

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases (IBD) have pathophysiological processes such as bowel necrosis enteric neurons glial cells. In addition, the main inflammatory mediator is related to tumor factor-alpha (TNF-α). TNF-α a me-diator intestinal processes, thus being one cytokines involved in pathogenesis IBD, however, its levels, when measured, present serum patients with IBD. plays an important role promoting inflammation, production interleukins (IL), for instance IL-1β IL-6. There two receptors TNF following: The factor 1 receptor (TNFR1); 2 (TNFR2). They IBD their been detected expression correlated activity. soluble form binds TNFR1 with, activation results signaling cascade effects apoptosis, cell proliferation cytokine secretion. contrast, transmembrane can bind both TNFR2. Recent studies suggested that pro-inflammatory since levels UC CD. Intravenous subcutaneous biologics targeting revolutionized treatment becoming best available agents induce maintain remission. application antibodies aimed at neutralizing satisfactory clinical response up 60% patients, also induced long-term maintenance remission most patients. It has anti-TNF-α inactivate by direct neutralization, i.e., resulting suppression inflammation. However, perform more complex functions than simple blockade.

Language: Английский

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Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 117956 - 117956

Published: Feb. 29, 2024

Language: Английский

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Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 2631 - 2647

Published: April 1, 2022

Background: An animal model of DSS-induced UC has been widely used in basic research, and the dysbiosis gut microbiome is one important pathogenetic mechanisms UC, but its dynamic changes correlation with inflammatory factors are not clear yet. Methods: Clinical signs tissue damage degree C57BL/6 ulcerative colitis mice induced by different concentrations DSS were compared that normal mice, finally optimal concentration was determined. Then we analyzed sequencing results to determine patterns their factors. Results: at 2.5% 3.0% could cause intestinal injury induce colitis. However, resulted higher mortality. In addition, there model: relative abundance flora increased first then decreased Bacteroides , Parabacteroides Romboutsia Clostridium_sensu_stricto_1, Lachnospiraceae_NK4A136_group, norank_f_norank_o_Clostridia_UCG-014, Parasutterella Lactobacillus Muribaculum norank_f_Muribaculaceae, Bifidobacterium Coriobacteriaceae_UCG-002 Enterorhabdus did change 14 days significantly on day 21. Moreover, cytokines closely associated imbalance microbiota UC: most pathogenic bacteria tract positively correlated pro-inflammatory negatively anti-inflammatory factors, while beneficial opposite. Conclusion: Intestinal microecology plays an role model, dynamically occurrence development Keywords: colitis, DSS, microbiome, changes, 16S rDNA

Language: Английский

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Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 3893 - 3911

Published: Sept. 1, 2022

Abstract: The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane (OMVs), have unique structure/composition/morphology characteristics, show excellent physical chemical/biochemical properties, making them a new generation theranostic nanomedicine. Here, we reviewed characteristics from perspective their formation biological function inflammatory bowel disease (IBD). Moreover, can crucially participate interaction communication intestinal epithelial cells (IECs)-immune cells-gut microbiota to regulate immune response, inflammation homeostasis. Interestingly, on current representative examples exosomes IBD treatment, it is shown that plant, milk, cells-derived exert therapeutic effect through components, proteins, nucleic acid, lipids. several drug loading methods target modification are used improve capability. We also discussed application treatment IBD. In this review, aim better more clearly clarify underlying mechanisms pathogenesis IBD, provide directions mediated treatment. Keywords: vesicles, exosome, nanoparticles, disease,

Language: Английский

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Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 20, 2023

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because an improperly managed immunological reactivity intestinal microbiota found in GIT. The immune response common commensal microbes plays essential role inflammation related UC synbiotics, and it important element optimal therapy UC. Therefore, i.e., mixture prebiotics probiotics, help control diseased state. Synbiotics alleviate colon by lowering reactive oxygen species (ROS) improving level antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). Prebiotic supplementation not practice at moment, despite numerous research findings proving that benefits both probiotics encourage their continued existence positioning GIT, with positive effects on human health managing response. However, fact there have been fewer studies treatment different coupled selected prebiotics, outcomes these very favorable. This evidence-based study explores possible ROS, SOD, synbiotics proposed review also focuses alteration gut microbiota, defense tract, management Thus, current article emphasizes oxidative stress signaling GI stress-based pathomechanisms patients, therapies inhibiting stress’ effects.

Language: Английский

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Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance

Life Sciences, Journal Year: 2023, Volume and Issue: 318, P. 121501 - 121501

Published: Feb. 15, 2023

Language: Английский

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Effects of four food hydrocolloids on colitis and their regulatory effect on gut microbiota

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121368 - 121368

Published: Sept. 9, 2023

Language: Английский

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Pathological mechanism and targeted drugs of ulcerative colitis: A review

Medicine, Journal Year: 2023, Volume and Issue: 102(37), P. e35020 - e35020

Published: Sept. 15, 2023

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with abdominal pain, diarrhea, and mucopurulent stools as main symptoms. Its incidence increasing worldwide, traditional treatments have problems such immunosuppression metabolic disorders. In this article, etiology pathogenesis ulcerative are reviewed to clarify targeted drugs UC in latest research. Our aim provide more ideas for clinical treatment new drug development UC, mainly by analyzing sorting out relevant literature on PubMed, summarizing finding that it related genetic, environmental, immune other factors, explaining its from NF-κB pathway, PI3K/Akt signaling JAK/STAT obtaining anti-TNF-α monoclonal antibodies, integrin antagonists, IL-12/IL-23 novel UC-targeted JAK inhibitors SIP receptor agonists. We believe rational selection formulation best dosing strategy under comprehensive consideration evaluation way treat UC.

Language: Английский

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Novel Natural Carrier‐Free Self‐Assembled Nanoparticles for Treatment of Ulcerative Colitis by Balancing Immune Microenvironment and Intestinal Barrier

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 8, 2023

Abstract Ulcerative colitis (UC) is a chronic inflammatory illness affecting the colon and rectum, with current treatment methods being unable to meet clinical needs of ulcerative patients. Although nanomedicines are recognized as promising anti‐inflammatory medicines, their application limited by high cost unpredictable safety risks. This study reveals that two natural phytochemicals, berberine (BBR) hesperetin (HST), self‐assemble directly form binary carrier‐free multi‐functional spherical nanoparticles (BBR‐HST NPs) through noncovalent bonds involving electrostatic interactions, π–π stacking, hydrogen bonding. Because synergistic activity, berberine–hesperetin exhibit significantly better therapeutic effects on UC inhibitory inflammation than BBR HST at same dose regulating immune microenvironment repairing damaged intestinal barrier. Furthermore, BBR‐HST NPs good biocompatibility biosafety. Thus, this proves potential novel agents for UC, which could promote progress drug development eventually benefit patients who suffering from it.

Language: Английский

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A‐type proanthocyanidins: Sources, structure, bioactivity, processing, nutrition, and potential applications

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2024, Volume and Issue: 23(3)

Published: April 18, 2024

A-type proanthocyanidins (PAs) are a subgroup of PAs that differ from B-type by the presence an ether bond between two consecutive constitutive units. This additional C-O-C gives them more stable and hydrophobic character. They increasing interest due to their potential multiple nutritional effects with low toxicity in food processing supplement development. have been identified several plants. However, role PAs, especially complex polymeric form (degree polymerization linkage), has not specifically discussed explored. Therefore, recent advances physicochemical structural changes functional properties during extraction, processing, storing evaluated. In addition, discussions on sources, structures, bioactivities, applications industry, future research trends derivatives highlighted. Litchis, cranberries, avocados, persimmons all favorable plant sources. Α-type contribute directly or indirectly human nutrition via regulation different degrees bonding types. Thermal could negative impact amount structure matrix. More attention should be focused nonthermal technologies better preserve architecture structure. The diversity complexity these compounds, as well difficulty isolating purifying natural remain obstacles further applications. received widespread acceptance industry but yet achieved maximum for food. Further development therefore needed.

Language: Английский

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