The Microbiota-Gut-Brain Axis

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(4), P. 1877 - 2013

Published: Aug. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Language: Английский

---

Introduction to the human gut microbiota

Biochemical Journal, Journal Year: 2017, Volume and Issue: 474(11), P. 1823 - 1836

Published: May 16, 2017

The human gastrointestinal (GI) tract harbours a complex and dynamic population of microorganisms, the gut microbiota, which exert marked influence on host during homeostasis disease. Multiple factors contribute to establishment microbiota infancy. Diet is considered as one main drivers in shaping across life time. Intestinal bacteria play crucial role maintaining immune metabolic protecting against pathogens. Altered bacterial composition (dysbiosis) has been associated with pathogenesis many inflammatory diseases infections. interpretation these studies relies better understanding inter-individual variations, heterogeneity communities along GI tract, functional redundancy need distinguish cause from effect states dysbiosis. This review summarises our current development its impact integrity health, underlying for mechanistic focusing host–microbe interactions.

Language: Английский

---

The role of short-chain fatty acids in microbiota–gut–brain communication

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 16(8), P. 461 - 478

Published: May 23, 2019

Language: Английский

---

Current understanding of the human microbiome

Nature Medicine, Journal Year: 2018, Volume and Issue: 24(4), P. 392 - 400

Published: April 1, 2018

Language: Английский

---

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

Molecular Psychiatry, Journal Year: 2016, Volume and Issue: 21(6), P. 786 - 796

Published: April 12, 2016

Language: Английский

---

Microbiota in health and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: April 23, 2022

Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.

Language: Английский

---

Interactions between the microbiota, immune and nervous systems in health and disease

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(2), P. 145 - 155

Published: Jan. 16, 2017

Language: Английский

---

The neuroactive potential of the human gut microbiota in quality of life and depression

Nature Microbiology, Journal Year: 2019, Volume and Issue: 4(4), P. 623 - 632

Published: Feb. 4, 2019

Language: Английский

---

The gut microbiota–brain axis in behaviour and brain disorders

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(4), P. 241 - 255

Published: Oct. 22, 2020

Language: Английский

---

Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

Journal of Psychiatric Research, Journal Year: 2016, Volume and Issue: 82, P. 109 - 118

Published: July 26, 2016

Language: Английский

---