Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection DOI Creative Commons

Shruti Shandilya,

Sandeep Kumar, Niraj Kumar Jha

et al.

Journal of Advanced Research, Journal Year: 2021, Volume and Issue: 38, P. 223 - 244

Published: Sept. 17, 2021

Recent research on the implications of gut microbiota brain functions has helped to gather important information relationship between them. Pathogenesis neurological disorders is found be associated with dysregulation gut-brain axis. Some bacteria metabolites are directly increase in reactive oxygen species levels, one most risk factors neurodegeneration. Besides their morbid association, also play a significant role reducing onset these life-threatening disorders.Studies done recent past raises two link and brain: "gut microbiota-oxidative stress-neurodegeneration" microbiota-antioxidant-neuroprotection. This review aims gives deep insight our readers, collective studies done, focusing mediated oxidative stress involved neurodegeneration along focus those showing involvement neuroprotection.This focused three main key concepts. Firstly, mounting evidences from clinical preclinical arenas shows influence resulting dysfunctional processes. Therefore, we describe potential influencing vulnerability stress, budding causative Alzheimer's Parkinson's disease. Secondly, contributing roles been observed attenuating inflammation via its own or by producing secondary and, modulation population antioxidative anti-inflammatory probiotics have shown promising neuro resilience. Thirdly, high throughput silico tools databases correlation microbiome, health, thus providing fascinating perspective new avenues for therapeutic options.

Language: Английский

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication DOI Creative Commons
Ygor Parladore Silva, Andressa Bernardi, Rudimar Luiz Frozza

et al.

Frontiers in Endocrinology, Journal Year: 2020, Volume and Issue: 11

Published: Jan. 31, 2020

A substantial body of evidence supports that the gut microbiota plays a pivotal role in regulation metabolic, endocrine and immune functions. In recent years, there has been growing recognition involvement modulation multiple neurochemical pathways through highly interconnected gut-brain axis. Although amazing scientific breakthroughs over last few years have expanded our knowledge on communication between microbes their hosts, underpinnings microbiota-gut-brain crosstalk remain to be determined. Short-chain fatty acids (SCFAs), main metabolites produced colon by bacterial fermentation dietary fibers resistant starch, are speculated play key neuro-immunoendocrine regulation. However, underlying mechanisms which SCFAs might influence brain physiology behavior not fully elucidated. this review, we will outline current about interactions. We also highlight how development future treatments for central nervous system (CNS) disorders can take advantage intimate mutual interactions with exploring function.

Language: Английский

Citations

1972
The gut microbiota–brain axis in behaviour and brain disorders DOI
Lívia H. Morais, Henry L. Schreiber, Sarkis K. Mazmanian

et al.

Nature Reviews Microbiology, Journal Year: 2020, Volume and Issue: 19(4), P. 241 - 255

Published: Oct. 22, 2020

Language: Английский

Citations

1472
The gut microbiome in neurological disorders DOI
John F. Cryan, Kenneth J. O’Riordan,

Kiran Sandhu

et al.

The Lancet Neurology, Journal Year: 2019, Volume and Issue: 19(2), P. 179 - 194

Published: Nov. 18, 2019

Language: Английский

Citations

1002
Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders DOI Open Access
Yijing Chen, Jinying Xu, Yu Chen

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 2099 - 2099

Published: June 19, 2021

Emerging evidence indicates that gut microbiota is important in the regulation of brain activity and cognitive functions. Microbes mediate communication among metabolic, peripheral immune, central nervous systems via microbiota–gut–brain axis. However, it not well understood how microbiome neurons mutually interact or these interactions affect normal functioning cognition. We summarize mechanisms whereby regulate production, transportation, neurotransmitters. also discuss dysbiosis affects function, especially neurodegenerative diseases such as Alzheimer’s disease Parkinson’s disease.

Language: Английский

Citations

546
The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders DOI Creative Commons
Katarzyna Socała, Urszula Doboszewska, Aleksandra Szopa

et al.

Pharmacological Research, Journal Year: 2021, Volume and Issue: 172, P. 105840 - 105840

Published: Aug. 24, 2021

Emerging evidence indicates that the gut microbiota play a crucial role in bidirectional communication between and brain suggesting microbes may shape neural development, modulate neurotransmission affect behavior, thereby contribute to pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, neurological conditions. This review summarizes recent data on microbiota-gut-brain axis pathophysiology neuropsychiatric disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, epilepsy. Also, involvement co-existing with conditions is highlighted. We discuss from both vivo preclinical experiments clinical reports including: (1) studies germ-free animals, (2) exploring composition animal models diseases or humans, (3) evaluating effects probiotic, prebiotic antibiotic treatment as well (4) fecal transplantation.

Language: Английский

Citations

511
Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health DOI Open Access
Aimée Parker, Sónia Fonseca, Simon R. Carding

et al.

Gut Microbes, Journal Year: 2019, Volume and Issue: 11(2), P. 135 - 157

Published: Aug. 1, 2019

The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of bacteria, archaea, viruses, fungi, protozoa, coexisting in a mutualistic relationship with the host. When intestinal homeostasis is perturbed, function tract other organ systems, including brain, can be compromised. gut proposed to contribute blood-brain barrier disruption pathogenesis neurodegenerative diseases. While progress being made, better understanding interactions between microbes host cells, impact these have on signaling from brain now required. In this review, we summarise current evidence their metabolites integrity function, communication networks which they may modulate. We also discuss potential modulation strategies as therapeutic tools for promoting restoring health.

Language: Английский

Citations

489
Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice DOI Creative Commons
Jing Sun, Jing‐Xuan Xu,

Yi Ling

et al.

Translational Psychiatry, Journal Year: 2019, Volume and Issue: 9(1)

Published: Aug. 5, 2019

Abstract Alzheimer’s disease (AD) is the most common dementia in elderly. Treatment for AD still a difficult task clinic. associated with abnormal gut microbiota. However, little known about role of fecal microbiota transplantation (FMT) AD. Here, we evaluated efficacy FMT treatment We used an APPswe/PS1dE9 transgenic (Tg) mouse model. Cognitive deficits, brain deposits amyloid-β (Aβ) and phosphorylation tau, synaptic plasticity as well neuroinflammation were assessed. Gut its metabolites short-chain fatty acids (SCFAs) analyzed by 16S rRNA sequencing 1 H nuclear magnetic resonance (NMR). Our results showed that could improve cognitive deficits reduce deposition mice. These improvements accompanied decreased tau protein levels Aβ40 Aβ42. observed increases Tg mice, showing postsynaptic density 95 (PSD-95) synapsin I expression increased after FMT. also decrease COX-2 CD11b mice found reversed changes SCFAs. Thus, may be potential therapeutic strategy

Language: Английский

Citations

395
Fecal microbiota transplantation protects rotenone-induced Parkinson’s disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis DOI Creative Commons
Zhe Zhao,

Jingwen Ning,

Xiu‐Qi Bao

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: Nov. 17, 2021

Parkinson's disease (PD) is a prevalent neurodegenerative disorder, displaying not only well-known motor deficits but also gastrointestinal dysfunctions. Consistently, it has been increasingly evident that gut microbiota affects the communication between and brain in PD pathogenesis, known as microbiota-gut-brain axis. As an approach to re-establishing normal community, fecal transplantation (FMT) exerted beneficial effects on recent studies. Here, this study, we established chronic rotenone-induced mouse model evaluate protective of FMT treatment explore underlying mechanisms, which proves involvement dysbiosis pathogenesis via axis.We demonstrated induced by rotenone administration caused function impairment poor behavioral performances mice. Moreover, 16S RNA sequencing identified increase bacterial genera Akkermansia Desulfovibrio samples By contrast, remarkably restored microbial thus ameliorating dysfunctions Further experiments revealed alleviated intestinal inflammation barrier destruction, reducing levels systemic inflammation. Subsequently, attenuated blood-brain (BBB) suppressed neuroinflammation substantia nigra (SN), further decreased damage dopaminergic neurons. Additional mechanistic investigation discovered reduced lipopolysaccharide (LPS) colon, serum, SN, thereafter suppressing TLR4/MyD88/NF-κB signaling pathway its downstream pro-inflammatory products both SN colon.Our current study demonstrates can correct ameliorate model, suppression mediated LPS-TLR4 possibly plays significant role. Further, prove involved genesis Video abstract.

Language: Английский

Citations

379
Microbiome–microglia connections via the gut–brain axis DOI Creative Commons
Reem Abdel-Haq, Johannes C. M. Schlachetzki, Christopher K. Glass

et al.

The Journal of Experimental Medicine, Journal Year: 2018, Volume and Issue: 216(1), P. 41 - 59

Published: Nov. 1, 2018

Microglia, the resident immune cells in brain, are essential for modulating neurogenesis, influencing synaptic remodeling, and regulating neuroinflammation by surveying brain microenvironment. Microglial dysfunction has been implicated onset progression of several neurodevelopmental neurodegenerative diseases; however, multitude factors signals microglial activity have not fully elucidated. Microglia only respond to local within but also receive input from periphery, including gastrointestinal (GI) tract. Recent preclinical findings suggest that gut microbiome plays a pivotal role maturation function, altered microbial community composition reported neurological disorders with known involvement humans. Collectively, these bidirectional crosstalk between may influence disease pathogenesis. Herein, we discuss recent studies showing development function homeostatic conditions highlight possible future research develop novel treatments brain.

Language: Английский

Citations

373
Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease DOI
Meng‐Fei Sun, Yan‐Qin Shen

Ageing Research Reviews, Journal Year: 2018, Volume and Issue: 45, P. 53 - 61

Published: April 26, 2018

Language: Английский

Citations

347