Neuroscience and Behavioral Physiology, Journal Year: 2022, Volume and Issue: 52(5), P. 722 - 738
Published: June 1, 2022
Language: Английский
Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)
Published: Nov. 4, 2021
Chronic unpredictable mild stress (CUMS) can not only lead to depression-like behavior but also change the composition of gut microbiome. Regulating microbiome have an antidepressant effect, mechanism by which it improves depressive symptoms is clear. Short-chain fatty acids (SCFAs) are small molecular compounds produced fermentation non-digestible carbohydrates. SFCAs ubiquitous in intestinal endocrine and immune cells, making them important mediators microbiome-regulated body functions. The balance between pro- anti-inflammatory microglia plays role occurrence treatment depression caused chronic stress. Non-absorbable antibiotic rifaximin regulate structure We hypothesized that protects against stress-induced inflammation behaviors regulating abundance fecal microbial metabolites microglial functions.We administered 150 mg/kg intragastrically rats exposed CUMS for 4 weeks investigated microbiome, content short-chain serum brain, functional profiles hippocampal neurogenesis.Our results show ameliorated depressive-like induced CUMS, as reflected sucrose preference, open field test Morris water maze. Rifaximin increased relative Ruminococcaceae Lachnospiraceae, were significantly positively correlated with high level butyrate brain. factors released microglia, prevented neurogenic abnormalities CUMS.These suggest inflammatory function play a protective pubertal neurodevelopment during acids.
Language: Английский
Citations
154
Current Research in Neurobiology, Journal Year: 2021, Volume and Issue: 2, P. 100013 - 100013
Published: Jan. 1, 2021
Through incorporating both physical and psychological forms of stressors, a variety rodent models have provided important insights into the understanding stress physiology. Rodent also significant information with regards to mechanistic basis pathophysiology stress-related disorders such as anxiety disorders, depressive illnesses, cognitive impairment post-traumatic disorder. Additionally, served valuable tools in area drug screening development for treatment stress-induced conditions. Although do not accurately reproduce biochemical or physiological parameters response cannot fully mimic natural progression human yet, animal research has answers many scientific questions. In this review article, studies utilizing are described terms their design apparatus, specific focus on capabilities generate reliable behavioral read-out. The focusses utility by discussing examples literature that offer physiologically relevant highlights advancing mission inquiry.
Language: Английский
Citations
111
Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)
Published: Nov. 27, 2023
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.
Language: Английский
Citations
84
Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 423 - 423
Published: Feb. 28, 2024
The involvement of central and peripheral inflammation in the pathogenesis prognosis major depressive disorder (MDD) has been demonstrated. increase pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, TNF-α) individuals with depression may elicit neuroinflammatory processes inflammation, mechanisms that, turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation dysbiosis induce alterations tryptophan metabolism, culminating decreased serotonin synthesis, impairments neuroplasticity-related mechanisms, glutamate-mediated excitotoxicity. This review aims highlight inflammatory (neuroinflammation, dysbiosis) involved pathophysiology MDD explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines evidence have indicated that addition antidepressants, physical exercise, probiotics, nutraceuticals (agmatine, ascorbic acid, vitamin D) possess effects their antidepressant properties. Further studies are necessary benefits these alternative therapies MDD.
Language: Английский
Citations
71
Brain Sciences, Journal Year: 2023, Volume and Issue: 13(12), P. 1610 - 1610
Published: Nov. 21, 2023
Neuroplasticity refers to the ability of brain reorganize and modify its neural connections in response environmental stimuli, experience, learning, injury, disease processes. It encompasses a range mechanisms, including changes synaptic strength connectivity, formation new synapses, alterations structure function neurons, generation neurons. plays crucial role developing maintaining function, learning memory, as well recovery from injury adaptation changes. In this review, we explore vast potential neuroplasticity various aspects across lifespan context disease. Changes aging significance cognitive later life will also be reviewed. Finally, discuss common mechanisms associated with age-related neurodegenerative processes (including protein aggregation accumulation, mitochondrial dysfunction, oxidative stress, neuroinflammation) how these can mitigated, at least partially, by non-invasive non-pharmacologic lifestyle interventions aimed promoting harnessing neuroplasticity.
Language: Английский
Citations
50
Phytomedicine, Journal Year: 2023, Volume and Issue: 113, P. 154725 - 154725
Published: Feb. 26, 2023
Language: Английский
Citations
43
Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 257, P. 108624 - 108624
Published: March 3, 2024
Language: Английский
Citations
18
Cells, Journal Year: 2021, Volume and Issue: 10(11), P. 2974 - 2974
Published: Nov. 1, 2021
Aging is the result of deterioration homeostatic systems (nervous, endocrine, and immune systems), which preserve organism’s health. We propose that age-related impairment these due to establishment a chronic oxidative stress situation leads low-grade inflammation throughout system’s activity. It known system weakens with age, increases morbidity mortality. In this context, we describe how function cells can be used as an indicator rate aging individual. addition passive role marker, work driver by amplifying oxidative-inflammatory associated (oxi-inflamm-aging) inducing senescence in far tissue cells. Further supporting our theory, discuss certain lifestyle conditions (such social environment, nutrition, or exercise) have impact on longevity affecting inflammatory state cells, regulating immunosenescence its contribution oxi-inflamm-aging.
Language: Английский
Citations
82
International Journal of Psychiatry in Clinical Practice, Journal Year: 2021, Volume and Issue: 26(2), P. 196 - 207
Published: Aug. 7, 2021
Objectives During the COVID-19 lockdown, social isolation and feelings of loneliness (SIFL) in older population have increased, they can be a risk dementia, especially vulnerable people. The current research is systematic review meta-analysis studies that approach dementia people with SIFL.
Language: Английский
Citations
72
Immunity, Journal Year: 2021, Volume and Issue: 54(9), P. 1933 - 1947
Published: Sept. 1, 2021
Language: Английский
Citations
63