Food & Function,
Journal Year:
2022,
Volume and Issue:
13(5), P. 2865 - 2883
Published: Jan. 1, 2022
Inflammatory
bowel
disease
(IBD)
is
accompanied
by
some
psychiatric
disorders,
including
anxiety
and
depression.
Sesamol
has
been
reported
to
alleviate
colitis
symptoms
depression-like
behaviors
caused
chronic
unpredictable
mild
stress,
but
its
protective
effect
underlying
neurobiological
mechanism
on
IBD
induced
dextran
sulfate
sodium
(DSS)
accompanying
anxiety-like
remains
still
unclear.
Here,
we
found
that
a
six-week
sesamol
treatment
(100
mg
per
kg
bodyweight
day)
for
DSS-induced
mice
predominantly
prevented
inflammatory
response,
epithelial
barrier
dysfunction
via
the
gut-brain
axis.
alleviated
neuroinflammatory
responses
suppressing
TLR-4/NF-κB
pathway,
protected
against
oxidative
stress
upregulated
Nrf2
antioxidant
signaling
pathway.
Moreover,
improved
brain-derived
neurotrophic
factor
(BDNF)
upregulating
BDNF/TrkB/CREB
restored
synaptic
impairments
enhanced
norepinephrine
(NE)
serotonin
(5-HT)
levels.
Importantly,
correlation
analysis
showed
gut
lipopolysaccharide
(LPS)
content
in
serum
were
highly
associated
with
behavioral
performance
biochemical
indexes
of
brain.
In
summary,
present
study
indicates
novel
nutritional
intervention
strategy
preventing
Journal of Neuroinflammation,
Journal Year:
2021,
Volume and Issue:
18(1)
Published: Nov. 4, 2021
Chronic
unpredictable
mild
stress
(CUMS)
can
not
only
lead
to
depression-like
behavior
but
also
change
the
composition
of
gut
microbiome.
Regulating
microbiome
have
an
antidepressant
effect,
mechanism
by
which
it
improves
depressive
symptoms
is
clear.
Short-chain
fatty
acids
(SCFAs)
are
small
molecular
compounds
produced
fermentation
non-digestible
carbohydrates.
SFCAs
ubiquitous
in
intestinal
endocrine
and
immune
cells,
making
them
important
mediators
microbiome-regulated
body
functions.
The
balance
between
pro-
anti-inflammatory
microglia
plays
role
occurrence
treatment
depression
caused
chronic
stress.
Non-absorbable
antibiotic
rifaximin
regulate
structure
We
hypothesized
that
protects
against
stress-induced
inflammation
behaviors
regulating
abundance
fecal
microbial
metabolites
microglial
functions.We
administered
150
mg/kg
intragastrically
rats
exposed
CUMS
for
4
weeks
investigated
microbiome,
content
short-chain
serum
brain,
functional
profiles
hippocampal
neurogenesis.Our
results
show
ameliorated
depressive-like
induced
CUMS,
as
reflected
sucrose
preference,
open
field
test
Morris
water
maze.
Rifaximin
increased
relative
Ruminococcaceae
Lachnospiraceae,
were
significantly
positively
correlated
with
high
level
butyrate
brain.
factors
released
microglia,
prevented
neurogenic
abnormalities
CUMS.These
suggest
inflammatory
function
play
a
protective
pubertal
neurodevelopment
during
acids.
Current Research in Neurobiology,
Journal Year:
2021,
Volume and Issue:
2, P. 100013 - 100013
Published: Jan. 1, 2021
Through
incorporating
both
physical
and
psychological
forms
of
stressors,
a
variety
rodent
models
have
provided
important
insights
into
the
understanding
stress
physiology.
Rodent
also
significant
information
with
regards
to
mechanistic
basis
pathophysiology
stress-related
disorders
such
as
anxiety
disorders,
depressive
illnesses,
cognitive
impairment
post-traumatic
disorder.
Additionally,
served
valuable
tools
in
area
drug
screening
development
for
treatment
stress-induced
conditions.
Although
do
not
accurately
reproduce
biochemical
or
physiological
parameters
response
cannot
fully
mimic
natural
progression
human
yet,
animal
research
has
answers
many
scientific
questions.
In
this
review
article,
studies
utilizing
are
described
terms
their
design
apparatus,
specific
focus
on
capabilities
generate
reliable
behavioral
read-out.
The
focusses
utility
by
discussing
examples
literature
that
offer
physiologically
relevant
highlights
advancing
mission
inquiry.
Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: Nov. 27, 2023
As
one
of
most
common
and
severe
mental
disorders,
major
depressive
disorder
(MDD)
significantly
increases
the
risks
premature
death
other
medical
conditions
for
patients.
Neuroinflammation
is
abnormal
immune
response
in
brain,
its
correlation
with
MDD
receiving
increasing
attention.
has
been
reported
to
be
involved
through
distinct
neurobiological
mechanisms,
among
which
dysregulation
neurogenesis
dentate
gyrus
(DG)
hippocampus
(HPC)
The
DG
two
niches
adult
mammalian
neurotrophic
factors
are
fundamental
regulators
this
process.
cell
types
mediating
neuroinflammation
include
microglia,
astrocytes,
oligodendrocytes,
meningeal
leukocytes,
peripheral
cells
selectively
penetrate
blood-brain
barrier
infiltrate
into
inflammatory
regions.
This
review
summarizes
functions
affected
by
during
progression
corresponding
influences
on
memory
patients
model
animals.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 423 - 423
Published: Feb. 28, 2024
The
involvement
of
central
and
peripheral
inflammation
in
the
pathogenesis
prognosis
major
depressive
disorder
(MDD)
has
been
demonstrated.
increase
pro-inflammatory
cytokines
(interleukin
(IL)-1β,
IL-6,
IL-18,
TNF-α)
individuals
with
depression
may
elicit
neuroinflammatory
processes
inflammation,
mechanisms
that,
turn,
can
contribute
to
gut
microbiota
dysbiosis.
Together,
neuroinflammation
dysbiosis
induce
alterations
tryptophan
metabolism,
culminating
decreased
serotonin
synthesis,
impairments
neuroplasticity-related
mechanisms,
glutamate-mediated
excitotoxicity.
This
review
aims
highlight
inflammatory
(neuroinflammation,
dysbiosis)
involved
pathophysiology
MDD
explore
novel
anti-inflammatory
therapeutic
approaches
for
this
psychiatric
disturbance.
Several
lines
evidence
have
indicated
that
addition
antidepressants,
physical
exercise,
probiotics,
nutraceuticals
(agmatine,
ascorbic
acid,
vitamin
D)
possess
effects
their
antidepressant
properties.
Further
studies
are
necessary
benefits
these
alternative
therapies
MDD.
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1610 - 1610
Published: Nov. 21, 2023
Neuroplasticity
refers
to
the
ability
of
brain
reorganize
and
modify
its
neural
connections
in
response
environmental
stimuli,
experience,
learning,
injury,
disease
processes.
It
encompasses
a
range
mechanisms,
including
changes
synaptic
strength
connectivity,
formation
new
synapses,
alterations
structure
function
neurons,
generation
neurons.
plays
crucial
role
developing
maintaining
function,
learning
memory,
as
well
recovery
from
injury
adaptation
changes.
In
this
review,
we
explore
vast
potential
neuroplasticity
various
aspects
across
lifespan
context
disease.
Changes
aging
significance
cognitive
later
life
will
also
be
reviewed.
Finally,
discuss
common
mechanisms
associated
with
age-related
neurodegenerative
processes
(including
protein
aggregation
accumulation,
mitochondrial
dysfunction,
oxidative
stress,
neuroinflammation)
how
these
can
mitigated,
at
least
partially,
by
non-invasive
non-pharmacologic
lifestyle
interventions
aimed
promoting
harnessing
neuroplasticity.
Cells,
Journal Year:
2021,
Volume and Issue:
10(11), P. 2974 - 2974
Published: Nov. 1, 2021
Aging
is
the
result
of
deterioration
homeostatic
systems
(nervous,
endocrine,
and
immune
systems),
which
preserve
organism’s
health.
We
propose
that
age-related
impairment
these
due
to
establishment
a
chronic
oxidative
stress
situation
leads
low-grade
inflammation
throughout
system’s
activity.
It
known
system
weakens
with
age,
increases
morbidity
mortality.
In
this
context,
we
describe
how
function
cells
can
be
used
as
an
indicator
rate
aging
individual.
addition
passive
role
marker,
work
driver
by
amplifying
oxidative-inflammatory
associated
(oxi-inflamm-aging)
inducing
senescence
in
far
tissue
cells.
Further
supporting
our
theory,
discuss
certain
lifestyle
conditions
(such
social
environment,
nutrition,
or
exercise)
have
impact
on
longevity
affecting
inflammatory
state
cells,
regulating
immunosenescence
its
contribution
oxi-inflamm-aging.
International Journal of Psychiatry in Clinical Practice,
Journal Year:
2021,
Volume and Issue:
26(2), P. 196 - 207
Published: Aug. 7, 2021
Objectives
During
the
COVID-19
lockdown,
social
isolation
and
feelings
of
loneliness
(SIFL)
in
older
population
have
increased,
they
can
be
a
risk
dementia,
especially
vulnerable
people.
The
current
research
is
systematic
review
meta-analysis
studies
that
approach
dementia
people
with
SIFL.
