Small,
Journal Year:
2023,
Volume and Issue:
19(19)
Published: Feb. 11, 2023
Abstract
Integrating
a
biomimetic
extracellular
matrix
to
improve
the
microenvironment
of
3D
printing
scaffolds
is
an
emerging
strategy
for
bone
substitute
design.
Here,
“soft–hard”
implant
(BM‐g‐DPCL)
consisting
bioactive
chemically
integrated
on
polydopamine
(PDA)‐coated
porous
gradient
scaffold
by
polyphenol
groups
constructed.
The
PDA‐coated
“hard”
promoted
Ca
2+
chelation
and
mineral
deposition;
“soft”
beneficial
migration,
proliferation,
osteogenic
differentiation
stem
cells
in
vitro,
accelerated
endogenous
cell
recruitment,
initiated
rapid
angiogenesis
vivo.
results
rabbit
cranial
defect
model
(Φ
=
10
mm)
confirmed
that
BM‐g‐DPCL
integration
between
tissue
induced
deposition
matrix.
Proteomics
cytokine
adhesion,
biomineralization,
vascularization,
formation
are
major
factors
accelerate
healing.
This
highly
bonded
soft–hard
components
guided
construction
regenerative
scaffold.
Journal of Materials Research and Technology,
Journal Year:
2022,
Volume and Issue:
18, P. 3240 - 3255
Published: April 14, 2022
Porosity
is
considered
to
be
one
of
the
key
factors
affecting
structural
properties
porous
lattices,
but
in
fact,
pore
size
also
plays
an
important
role,
and
it
has
great
potential
adjust
porosity
independently
improve
properties.
In
this
work,
by
adjusting
sheet
thickness
triply
periodic
minimal
surface
(TPMS)
lattice
structures
height
single
row
structure
according
linear
constant
laws,
TPMS
with
given
adjustable
are
designed,
mechanical
response
investigated.
Based
on
preparing
samples
Ti6Al4V
laser
powder
bed
fusion,
results
tests
show
that
elastic
modulus
ranges
change
(LC-TPMS)
(C-TPMS)
3625.6
MPa–4575.1
MPa
3820.0
MPa–4509.1
MPa,
respectively.
plateau
stage,
LC-TPMS
have
a
longer
more
stable
higher
yield
stress
better
energy
absorption
capacity
than
C-TPMS
structures.
The
maximum
difference
62.7
MJ/mm3
efficiency
0.12.
can
obtain
larger
damping
ratio
under
compressive
strain.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
10
Published: March 1, 2022
With
the
development
of
three-dimensional
(3D)
printed
technology,
3D
alloy
implants,
especially
titanium
alloy,
play
a
critical
role
in
biomedical
fields
such
as
orthopedics
and
dentistry.
However,
untreated
implants
always
possess
bioinert
surface
that
prevents
interface
osseointegration,
which
is
necessary
to
perform
modification
enhance
its
biological
functions.
In
this
article,
we
discuss
principles
processes
chemical,
physical,
technologies
on
detail.
Furthermore,
challenges
antibacterial,
osteogenesis,
mechanical
properties
3D-printed
by
are
summarized.
Future
research
studies,
including
combination
multiple
or
coordination
structure
composition
composite
coating
also
present.
This
review
provides
leading-edge
functionalization
strategies
implants.
Journal of Orthopaedic Surgery and Research,
Journal Year:
2022,
Volume and Issue:
17(1)
Published: Feb. 2, 2022
Abstract
Background
Titanium
and
its
alloys
have
been
widely
employed
for
bone
tissue
repair
implant
manufacturing.
The
rapid
development
of
three-dimensional
(3D)
printing
technology
has
allowed
fabrication
porous
titanium
scaffolds
with
controllable
microstructures,
which
is
considered
to
be
an
effective
method
promoting
formation
decreasing
absorption.
purpose
this
systematic
review
was
evaluate
the
osteogenic
potential
3D-printed
Ti6Al4V
(Ti64)
scaffold
repairing
long
defects
in
animal
models
investigate
influential
factors
that
might
affect
capacity.
Methods
Electronic
literature
search
conducted
following
databases:
PubMed,
Web
Science,
Embase
up
September
2021.
SYRCLE's
tool
modified
CAMARADES
list
were
used
assess
risk
bias
methodological
quality,
respectively.
Due
heterogeneity
selected
studies
relation
protocol
outcomes
evaluated,
a
meta-analysis
could
not
performed.
Results
initial
revealed
5858
studies.
Only
46
found
eligible
based
on
inclusion
criteria.
Rabbit
most
commonly
utilized
model.
A
pore
size
around
500–600
µm
porosity
60–70%
ideal
parameters
designing
Ti64
scaffold,
where
both
dodecahedron
diamond
pores
optimally
promoted
osteogenesis.
Histological
analysis
rabbit
model
maximum
area
fraction
reached
59.3
±
8.1%
at
weeks
8–10.
Based
micro-CT
assessment,
volume
34.0
6.0%
12.
Conclusions
act
as
promising
medium
providing
sufficient
mechanical
support
stable
environment
new
defects.
Trail
registration
study
registered
PROSPERO
database
under
number
CRD42020194100.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: Oct. 19, 2023
Abstract
Elimination
of
bacterial
infections
and
simultaneously
promoting
osteogenic
differentiation
are
highly
required
for
infectious
bone
diseases.
Massive
reactive
oxygen
species
(ROS)
can
damage
cells,
while
low
ROS
concentrations
as
a
molecular
signal
regulate
cellular
fate.
In
this
study,
Janus‐ROS
healing
system
is
developed
regeneration.
An
alendronate
(ALN)‐mediated
defective
metal–organic
framework
(MOF)
sonosensitizer
prepared,
which
effectively
clear
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
promote
under
differential
ultrasonic
irradiation.
the
presence
zirconium–phosphate
coordination,
ALN‐mediated
porphyrin‐based
MOF
(HN25)
with
proper
defect
has
great
sonodynamic
antibacterial
efficiency
(98.97%,
15
min)
bone‐targeting
ability.
Notably,
low‐power
ultrasound
irradiation,
HN25
increase
chromatin
accessibility
ossification‐related
genes
FOXO1
to
repair
through
concentrations.
Animal
models
paravertebral
infection,
fracture
osteomyelitis
demonstrate
that
successfully
realizes
targeted
potent
various
tissues
rapid
MRSA
elimination,
inhibiting
osteoclast
activity
The
results
show
high
catalytic
bioactive
be
constructed
using
pharmaceutical‐mediated
engineering.
treatment
also
promising
therapeutic
mode
tissue
Bioactive Materials,
Journal Year:
2023,
Volume and Issue:
24, P. 450 - 462
Published: Jan. 3, 2023
Infected
bone
defects
(IBDs)
remains
a
challenging
problem
for
orthopedists.
Clinically,
routine
management
IBDs
has
two
stages:
debridement
and
systematic
antibiotics
administration
to
control
infection,
secondary
grafting
repair
defects.
Whereas
the
efficacy
is
not
satisfactory,
because
overuse
of
may
lead
systemic
toxicity,
emergence
drug-resistant
bacteria,
as
well
surgery
would
cause
additional
trauma
economic
burden
patients.
Therefore,
it
imperative
develop
novel
scaffold
one-stage
IBDs.
In
this
study,
vancomycin
(Van)
was
encapsulated
into
poly(lactic
co-glycolic
acid)
(PLGA)
microspheres
through
double
emulsion
method,
which
were
then
loaded
additively-manufactured
porous
tantalum
(AM-Ta)
gelatin
methacryloyl
(GelMA)
hydrogel
produce
composite
Ta/GelMA
(Gel)/PLGA/vancomycin(Van)
scaffolds
repairing
Physiochemical
characterization
newly-developed
indicated
that
releasing
duration
Van
over
2
weeks.
Biological
experiments
good
biocompatibility
scaffold,
bacteriostasis
osteointegration
properties,
showed
great
potential
clinical
application.
The
construction
provide
new
sight
development
orthopaedic
implants,
shedding
light
on
treatment
Gels,
Journal Year:
2023,
Volume and Issue:
9(5), P. 423 - 423
Published: May 18, 2023
Although
titanium
and
alloys
have
become
the
preferred
materials
for
various
medical
implants,
surface
modification
technology
still
needs
to
be
strengthened
in
order
adapt
complex
physiological
environment
of
human
body.
Compared
with
physical
or
chemical
methods,
biochemical
modification,
such
as
introduction
functional
hydrogel
coating
on
can
fix
biomolecules
proteins,
peptides,
growth
factors,
polysaccharides,
nucleotides
so
that
they
directly
participate
biological
processes;
regulate
cell
adhesion,
proliferation,
migration,
differentiation;
improve
activity
implants.
This
review
begins
a
look
at
common
substrate
coatings
implant
surfaces,
including
natural
polymers
collagen,
gelatin,
chitosan,
alginate,
synthetic
polyvinyl
alcohol,
polyacrylamide,
polyethylene
glycol,
polyacrylic
acid.
Then,
construction
methods
(electrochemical
method,
sol–gel
method
layer-by-layer
self-assembly
method)
are
introduced.
Finally,
five
aspects
enhancement
effect
bioactivity
alloy
implants
described:
osseointegration,
angiogenesis,
macrophage
polarization,
antibacterial
effects,
drug
delivery.
In
this
paper,
we
also
summarize
latest
research
progress
point
out
future
direction.
After
searching,
no
previous
relevant
literature
reporting
information
was
found.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
487, P. 150585 - 150585
Published: March 20, 2024
Diabetic
bone
defect
repair
is
one
of
the
major
challenges
in
clinic,
because
pathological
microenvironments
such
as
hyperglycemia,
oxidative
stress,
and
inflammation
exist
area
diabetes
mellitus.
Although
current
tissue-engineered
has
achieved
favorable
regeneration
functional
reconstruction,
it
still
unsatisfactory
for
diabetic
only
by
correcting
a
single
factor.
In
this
study,
we
develop
multifunctional
nano-releasing
system
GelMA/HAMA
microgels-encapsulated
Mg2+/Emodin
(MgEm)
nanorods
based
on
MOF
design
principle
(denoted
MEGH)
reversing
microenvironment.
For
slow-release
MEGH
microgels,
Emodin
exert
hypoglycemic,
antioxidant,
anti-inflammatory
function,
while
Mg2+
ions
could
promote
angiogenesis
regeneration.
Subsequently,
combine
decalcified
matrix
with
regenerative
units
BMSCs-loaded
microgels
(BMSCs@MEGH-D)
construction
bone.
Finally,
pre-constructed
BMSCs@MEGH-D
scaffolds
successfully
vascularized
rabbit
skull
models
due
to
effective
correction
The
underlying
mechanism
indicates
synergetic
efficacy
regulate
glucose,
inflammation,
oxygen-related
bioprocesses,
well
osteogenesis-related
pathways.
Our
findings
provide
promising
treatment
microenvironment
accelerate
repair.
