Macromolecular Bioscience,
Journal Year:
2023,
Volume and Issue:
24(3)
Published: Aug. 13, 2023
Abstract
Cancer
development
and
progression
of
cancer
are
closely
associated
with
the
activation
oncogenes
loss
tumor
suppressor
genes.
Nucleic
acid
drugs
(e.g.,
siRNA,
mRNA,
DNA)
widely
used
for
therapy
due
to
their
specific
ability
regulate
expression
any
cancer‐associated
However,
nucleic
negatively
charged
biomacromolecules
that
susceptible
serum
nucleases
cannot
cross
cell
membrane.
Therefore,
delivery
tools
required
facilitate
intracellular
drugs.
In
past
few
decades,
a
variety
nanoparticles
(NPs)
designed
developed
therapy.
particular,
polymeric
NPs
in
response
abnormal
redox
status
cells
have
garnered
much
more
attention
as
potential
redox‐triggered
nanostructure
dissociation
rapid
release
this
review,
important
genes
or
signaling
pathways
regulating
briefly
introduced
recent
redox‐responsive
is
systemically
summarized.
The
future
NPs‐mediated
challenges
clinical
translation
also
discussed.
Journal of Functional Biomaterials,
Journal Year:
2025,
Volume and Issue:
16(1), P. 8 - 8
Published: Jan. 1, 2025
Each
year,
the
number
of
cases
strokes
and
deaths
due
to
this
is
increasing
around
world.
This
could
be
work
stress,
lifestyles,
unhealthy
food
habits,
several
other
reasons.
Currently,
there
are
traditional
methods
like
thrombolysis
mechanical
thrombectomy
for
managing
strokes.
The
current
approach
has
limitations,
delayed
diagnosis,
limited
therapeutic
delivery,
risks
secondary
injuries.
So,
a
need
some
effective
reliable
management
strokes,
which
help
in
early
diagnosis
followed
by
treatment
Nanotechnology
played
an
immense
role
recently,
it
emerged
as
transformative
solution
offering
innovative
diagnostic
tools
strategies.
Nanoparticles
(NPs)
belonging
classes,
including
metallic
(metallic
metal
oxide),
organic
(lipids,
liposome),
carbon,
can
cross
blood–brain
barrier
may
exhibit
potential
various
Moreover,
these
NPs
have
exhibited
promise
improving
imaging
specificity
delivery
precise
drug
real-time
monitoring
efficacy.
Nanomaterials
cerium
oxide
(CeO2)
liposome-encapsulated
agents
neuroprotective
properties
that
reduce
oxidative
stress
promote
neuroregeneration.
In
present
article,
authors
emphasized
significant
advancements
nanomedicine
stroke,
NPs-based
systems,
neuroregenerative
therapies,
multimodal
advancements.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
10(9), P. 3438 - 3449
Published: Jan. 1, 2023
Advanced
elastomers
are
highly
demanded
for
the
fabrication
of
medical
devices
minimally
invasive
surgery
(MIS).
A
diselenide-containing,
shape-memory
and
self-healing
polyurethane
MIS
is
illustrated
in
myocardial
infarction
therapy.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 3, 2024
Abstract
Kaempferol
(KA),
an
natural
antioxidant
of
traditional
Chinese
medicine
(TCM),
is
extensively
used
as
the
primary
treatment
for
inflammatory
digestive
diseases
with
impaired
redox
homeostasis.
Severe
acute
pancreatitis
(SAP)
was
exacerbated
by
mitochondrial
dysfunction
and
abundant
ROS,
which
highlights
role
antioxidants
in
targeting
function.
However,
low
bioavailability
high
dosage
KA
leading
to
unavoidable
side
effects
limits
clinical
transformation.
The
mechanisms
poor
largely
unexplored,
hindering
development
efficient
strategies
maximizing
medicinal
KA.
Here,
we
engineered
a
novel
thioketals
(TK)-modified
based
on
DSPE-PEG2000
liposomal
codelivery
system
improving
avoiding
(denotes
DSPE-TK-PEG2000-KA,
DTM@KA
NPs).
We
demonstrated
that
liposome
exerts
profound
impacts
damaging
intracellular
homeostasis
reducing
GSH
depletion
activating
Nrf2,
synergizes
reinforce
inhibition
inadequate
fission,
excessive
fusion
mitophagy
resulting
inflammation
apoptosis;
then,
restored
strengthens
ATP
supply
PAC
renovation
Interestingly,
TK
bond
proved
main
functional
structure
improve
above
efficacy
compared
absence
bond.
Most
importantly,
NPs
obviously
suppresses
death
negligible
vitro
vivo.
Mechanismly,
facilitated
STAT6-regulated
precursor
proteins
transport
via
interacting
TOM20
further
promote
Drp1-dependent
fission
Pink1/Parkin-regulated
enhanced
lysosomal
degradation
removing
damaged
mitochondria
then
reduce
apoptosis.
Generally,
synergistically
improved
homeostasis,
energy
metabolism
response
regulating
TOM20-STAT6-Drp1
signaling
promoting
SAP.
Consequently,
such
TCM’s
active
ingredients-based
nanomedicine
strategy
be
expected
innovative
approach
SAP
therapy.
Graphical
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 13, 2024
Abstract
Acute
lung
injury
(ALI)
poses
a
significant
and
escalating
medical
challenge,
where
precise
diagnosis
timely
intervention
hold
utmost
importance
in
halting
its
deterioration.
Nevertheless,
persistent
obstacles
arise
from
the
lack
of
agents
proficient
both
real‐time
efficient
mitigation
ALI.
Here,
biocatalytic
second
near‐infrared
(NIR‐II)
fluorescence‐illuminating
nanoplatform
is
designed
to
simultaneously
facilitate
monitoring
robust
inflammation
alleviation
The
study
first
develops
new
aggregation‐induced
emission
luminogen
with
trifluoromethyl
substitutions,
which
increase
NIR‐II
wavelength
fluorescence
brightness.
molecular
probe
further
integrated
into
hollow
ceria
nanostructures,
cloaked
pre‐activated
macrophage
membranes
for
targeted
intervention.
Upon
inhalation
administration
ALI
mice,
theranostic
nanoagents
leverage
bright
active
inflammation‐tropic
properties
vivo
sensitive
imaging
ALI,
also
facilitates
tracking
nanoagents’
distribution
dynamic
fate
within
pneumonia
milieu.
Concurrently,
catalytic
prowess
nanoplatforms
efficaciously
scavenges
excess
reactive
oxygen
species,
dampens
proinflammatory
cytokines,
promotes
repolarization,
substantially
alleviating
acute
damage.
multifaceted
integrates
bioimaging
nanocatalysis‐mediated
immunoregulation,
offering
versatile
promising
approach
addressing
intricate
challenges
posed
by
diseases.
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 5, 2024
Abstract
Background
Inflammation
and
endothelial
barrier
dysfunction
are
the
major
pathophysiological
changes
in
acute
respiratory
distress
syndrome
(ARDS).
Sphingosine-1-phosphate
receptor
3
(S1PR3),
a
G
protein-coupled
receptor,
has
been
found
to
mediate
inflammation
cell
(EC)
integrity.
However,
function
of
S1PR3
ARDS
not
fully
elucidated.
Methods
We
used
murine
lipopolysaccharide
(LPS)-induced
model
an
LPS-
stimulated
ECs
investigate
role
anti-inflammatory
effects
protection
during
ARDS.
Results
that
expression
was
increased
lung
tissues
mice
with
LPS-induced
TY-52156,
selective
inhibitor,
effectively
attenuated
by
suppressing
proinflammatory
cytokines
restored
repairing
adherens
junctions
reducing
vascular
leakage.
inhibition
achieved
adeno-associated
virus
vivo
small
interfering
RNA
vitro.
Both
vitro
studies
demonstrated
pharmacological
or
genetic
protected
against
inhibiting
NF-κB
pathway
improving
mitochondrial
oxidative
phosphorylation.
Conclusions
protects
via
suppression
pulmonary
promotion
phosphorylation,
indicating
is
potential
therapeutic
target
for
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
