Tumbler‐Inspired Microneedle Containing Robots: Achieving Rapid Self‐Orientation and Peristalsis‐Resistant Adhesion for Colonic Administration DOI
Libing Huang, Lihuang Li, Yanjie Jiang

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(43)

Published: June 25, 2023

Abstract Microneedle containing miniature robots offer a promising route for gastrointestinal administration since their capability of transmucosal delivery and controllable drug release. However, many challenges still lie ahead such as the intricate control modes, destitute systematic theory locomotion adhesion behaviors, failure due to peristalsis fluid flow, risk ileus. Herein, an untethered microneedle is designed specific colonic administration, which can dispense with systems, achieve fast self‐orientation onto mucosa (<0.6 s), against physiology peristalsis, show low risks obstruction. Further, detachable layer between degrade under time 6 min, ensures safely discharge small, excreted force 20 mN induced by flow. Through optimism microneedles, different release times be achieved including 14 2 days, 4 30 respectively. The in vivo experiments also demonstrate effectiveness feasibility robots. These serve versatile platform treat diseases chronic inflammation cancer colon minimize invasive surgical intervention patient suffering.

Language: Английский

Stimuli-activatable nanomedicine meets cancer theranostics DOI Creative Commons
Haonan Li, Feng Yue, Qiang Luo

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

Citations

147
Impairing Tumor Metabolic Plasticity via a Stable Metal‐Phenolic‐Based Polymeric Nanomedicine to Suppress Colorectal Cancer DOI
Xiaoling Li, Zhenyu Duan, Xiaoting Chen

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 14, 2023

Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However, the therapeutic efficacy existing metabolism-regulating agents often compromised due to tolerance resulting from plasticity, as well their poor bioavailability and tumor-targetability. Inspired by inhibitive effect N-ethylmaleimide on mitochondrial function, dendronized-polymer-functionalized metal-phenolic nanomedicine (pOEG-b-D-SH@NP) encapsulating maleimide-modified doxorubicin (Mal-DOX) developed enable improvement in overall delivery efficiency inhibition metabolism via multiple pathways. It observed that Mal-DOX its derived induces energy depletion CT26 colorectal cancer more efficiently than doxorubicin, shifts balance programmed cell death apoptosis toward necroptosis. Notably, pOEG-b-D-SH@NP simultaneously inhibits cellular oxidative phosphorylation glycolysis, thus potently suppressing growth peritoneal intestinal metastasis mouse models. Overall, study provides dendronized-polymer-derived nanoplatform for treatment cancers through impairing plasticity.

Language: Английский

Citations

67
Dendritic Nanomedicine with Boronate Bonds for Augmented Chemo‐Immunotherapy via Synergistic Modulation of Tumor Immune Microenvironment DOI Open Access
Yunkun Li, Yahui Wu,

Zaixiang Fang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Sept. 25, 2023

Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated immunosuppressive microenvironment diminish the immune response rate therapeutic effect. Surface modification these with target ligands can promote their cellular internalization, but modified may be subjected to unexpected recognition clearance. Herein, phenylboronic acid (PBA) group-shieldable dendritic nanomedicine that integrates an immunogenic cell death (ICD)-inducing agent (epirubicin, Epi) indoleamine 2,3-dioxgenase 1 (IDO1) inhibitor (NLG919) is reported for chemo-immunotherapy. This NLG919-loaded Epi-conjugated PEGylated dendrimers bridged boronate bonds (NLG919@Epi-DBP) maintains stable nanostructure during circulation. Under moderate acidic condition, PBA group exposes sialic residue on membrane enhance internalization penetration NLG919@Epi-DBP. At pH 5.0, NLG919@Epi-DBP rapidly disassembles release incorporated Epi NLG919. triggers robust ICD cells evokes strong response. In addition, inhibition IDO1 activity downregulates metabolism L-tryptophan kynurenine, leading reduction in recruitment modulation microenvironment. Collectively, this promising strategy has been demonstrated evoke as well remodel enhanced chemo-immunotherapeutic

Language: Английский

Citations

44
Recent advances in nanoparticle-based approaches for the treatment of brain tumors: Opportunities and challenges DOI
Jisan Ahamed, B.H. Jaswanth Gowda, Waleed Hassan Almalki

et al.

European Polymer Journal, Journal Year: 2023, Volume and Issue: 193, P. 112111 - 112111

Published: May 5, 2023

Language: Английский

Citations

43
Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy DOI Creative Commons
Zhilin Li, Qianfeng Zhang, Zhiqian Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(5), P. 2194 - 2209

Published: March 2, 2024

Despite the great potential of anti-PD-L1 antibodies for immunotherapy, their low response rate due to an immunosuppressive tumor microenvironment has hampered application. To address this issue, we constructed a cell membrane-coated nanosystem (mB4S) reverse immuno-supportive one strengthening anti-tumor effect. In system, Epirubicin (EPI) as immunogenic death (ICD) inducer was coupled branched glycopolymer

Language: Английский

Citations

29
Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications DOI Open Access
Mariana Fonseca, Ivana Jarak,

Francis Victor

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 319 - 319

Published: Jan. 8, 2024

Polymersomes are artificial nanoparticles formed by the self-assembly process of amphiphilic block copolymers composed hydrophobic and hydrophilic blocks. They can encapsulate molecules in aqueous core within membrane. The composition be tuned, enabling control characteristics properties polymersomes and, thus, their application areas such as drug delivery, diagnostics, or bioimaging. preparation methods also impact preservation encapsulated drugs. Many have been described, including direct hydration, thin film electroporation, pH-switch method, solvent shift single double emulsion flash nanoprecipitation, microfluidic synthesis. Considering polymersome structure composition, there several types theranostic polymersomes, decorated with targeting ligands for selective stimuli-responsive porous multiple promising applications. Due to shortcomings related stability, efficacy, safety some therapeutics human body, delivery systems good candidates improve quality therapies against a wide range diseases, cancer. Chemotherapy immunotherapy improved using deliver drugs, protecting directing them exact site action. Moreover, this approach is targeted biologics since they represent class drugs poor stability high susceptibility vivo clearance. However, lack well-defined regulatory plan formulations has hampered follow-up clinical trials subsequent market entry.

Language: Английский

Citations

17
Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives DOI Creative Commons

Xiaoding Shen,

Dayi Pan, Qiyong Gong

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 445 - 472

Published: Oct. 26, 2023

Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.

Language: Английский

Citations

40
Recent Studies and Progress in the Intratumoral Administration of Nano-Sized Drug Delivery Systems DOI Creative Commons

Wan Su Yun,

Soo Hyun Kim,

Dong-Kwon Lim

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2225 - 2225

Published: July 31, 2023

Over the last 30 years, diverse types of nano-sized drug delivery systems (nanoDDSs) have been intensively explored for cancer therapy, exploiting their passive tumor targetability with an enhanced permeability and retention effect. However, systemic administration has aroused some unavoidable complications, including insufficient tumor-targeting efficiency, side effects due to undesirable biodistribution, carrier-associated toxicity. In this review, recent studies advancements in intratumoral nanoDDS are generally summarized. After identifying factors be considered enhance therapeutic efficacy administration, experimental results on application various therapies discussed. Subsequently, reports clinical addressed short. Intratumoral is proven its versatility tumor-specific accumulation agents modalities. Specifically, it can improve poor bioavailability by increasing concentration, while minimizing effect highly toxic restricting normal tissues. expand area potent ability relieve toxicities nanoDDSs.

Language: Английский

Citations

29
Mitocytosis Mediated by an Enzyme‐Activable Mitochondrion‐Disturbing Polymer‐Drug Conjugate Enhances Active Penetration in Glioblastoma Therapy DOI

Yufan Xiang,

Bing Wang, Wanchun Yang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Feb. 1, 2024

The application of nanomedicines for glioblastoma (GBM) therapy is hampered by the blood-brain barrier (BBB) and dense tissue. To achieve efficient BBB crossing deep GBM penetration, this work demonstrates a strategy active transcellular transport mitochondrion-disturbing nanomedicine, pGBEMA

Language: Английский

Citations

12
Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics DOI
Duy-Thuc Nguyen, Min‐Jun Baek, Sang Min Lee

et al.

Nature Nanotechnology, Journal Year: 2024, Volume and Issue: 19(11), P. 1723 - 1734

Published: Aug. 21, 2024

Language: Английский

Citations

12