Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
39, P. 544 - 561
Published: May 30, 2024
Once
bone
metastasis
occurs
in
lung
cancer,
the
efficiency
of
treatment
can
be
greatly
reduced.
Current
mainstream
treatments
are
focused
on
inhibiting
cancer
cell
growth
and
preventing
destruction.
Microwave
ablation
(MWA)
has
been
used
to
treat
tumors.
However,
MWA
may
damage
surrounding
normal
tissues.
Therefore,
it
could
beneficial
develop
a
nanocarrier
combined
with
microwave
metastasis.
Herein,
microwave-responsive
nanoplatform
(MgFe
Theranostics,
Journal Year:
2024,
Volume and Issue:
15(3), P. 993 - 1016
Published: Dec. 2, 2024
Immunotherapy
has
transformed
current
cancer
management,
and
it
achieved
significant
progress
over
last
decades.
However,
an
immunosuppressive
tumor
microenvironment
(TME)
diminishes
the
effectiveness
of
immunotherapy
by
suppressing
activity
immune
cells
facilitating
immune-evasion.
Adenosine
monophosphate-activated
protein
kinase
(AMPK),
a
key
modulator
cellular
energy
metabolism
homeostasis,
gained
growing
attention
in
anti-tumor
immunity.
Metformin
is
usually
considered
as
cornerstone
diabetes
its
role
activating
AMPK
pathway
also
been
extensively
explored
therapy
although
findings
on
remain
inconsistent.
nanomedicine
formulation
found
to
hold
potential
reprogramming
TME
through
immunometabolic
modulation
both
cells.
This
review
elaborates
foundation
via
metformin-based
nanomedicines,
offering
valuable
insights
for
next
generation
therapy.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 12, 2024
Abstract
The
dense
extracellular
matrix
(ECM)
in
solid
tumors,
contributed
by
cancer‐associated
fibroblasts
(CAFs),
hinders
penetration
of
drugs
and
diminishes
their
therapeutic
outcomes.
A
sequential
treatment
strategy
remodeling
the
ECM
via
a
CAF
modifier
(dasatinib,
DAS)
is
proposed
to
promote
an
immunogenic
cell
death
(ICD)
inducer
(epirubicin,
Epi)
apoptotic
vesicles,
ultimately
enhancing
efficacy
against
breast
cancer.
Dendritic
poly(oligo(ethylene
glycol)
methyl
ether
methacrylate)
(POEGMA)‐based
nanomedicines
(poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS]
(P‐DAS)
poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi]
(P‐Epi))
are
developed
for
delivery
DAS
Epi,
respectively.
P‐DAS
reprograms
CAFs
reduce
collagen
downregulating
anabolism
energy
metabolism,
thereby
reducing
deposition.
regulated
can
enhance
tumor
P‐Epi
strengthen
its
ICD
effect,
leading
amplified
antitumor
immune
response.
In
cancer‐bearing
mice,
this
approach
alleviates
barrier,
resulting
reduced
burden
increased
cytotoxic
T
lymphocyte
infiltration,
more
encouragingly,
synergizes
effectively
with
anti‐programmed
1
(PD‐1)
therapy,
significantly
inhibiting
growth
preventing
lung
metastasis.
Furthermore,
systemic
toxicity
barely
detectable
after
P‐Epi.
This
opens
new
avenue
treating
desmoplastic
tumors
metabolically
targeting
overcome
barrier.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(22), P. 10800 - 10826
Published: Jan. 1, 2024
This
review
provides
a
guideline
for
the
rational
design
of
metal–phenolic
network
(MPN)
composites—which
are
fabricated
from
MPN
and
one
or
more
functional
components
(
e.g.
,
drugs,
proteins)—for
various
applications
across
diverse
disciplines.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 11, 2025
Hypoxic
tumors
present
a
significant
challenge
in
cancer
therapy
due
to
their
ability
adaptation
low-oxygen
environments,
which
supports
tumor
survival
and
resistance
treatment.
Enhanced
mitophagy,
the
selective
degradation
of
mitochondria
by
autophagy,
is
crucial
mechanism
that
helps
sustain
cellular
homeostasis
hypoxic
tumors.
In
this
study,
we
develop
an
azocalix[4]arene-modified
supramolecular
albumin
nanoparticle,
co-delivers
hydroxychloroquine
mitochondria-targeting
photosensitizer,
designed
induce
cascaded
oxidative
stress
regulating
mitophagy
for
treatment
These
nanoparticles
are
hypoxia-responsive
release
loaded
guest
molecules
cells.
The
released
disrupts
process,
thereby
increasing
further
weakening
Additionally,
upon
laser
irradiation,
photosensitizer
generates
reactive
oxygen
species
independent
oxygen,
inducing
damage
activation.
dual
action
simultaneous
spatiotemporal
activation
flux
blockade
results
enhanced
autophagic
stress,
ultimately
driving
cell
death.
Our
work
highlights
effectiveness
hydroxychloroquine-mediated
combined
with
mitochondria-targeted
cascade-amplified
against
has
been
recognized
as
Here,
group
fabricates
nanoparticle
codelivering
(HCQ)
sulfur-substituted
methylated
nile
blue
analog,
capable
via
European Polymer Journal,
Journal Year:
2024,
Volume and Issue:
208, P. 112891 - 112891
Published: Feb. 27, 2024
Cancer
remains
a
major
global
health
challenge,
with
increasing
incidence
and
mortality
rates
projected
for
the
coming
years.
Lung
cancer,
in
particular,
poses
significant
obstacles
due
to
late-stage
diagnosis
limited
treatment
options.
While
advancements
molecular
diagnostics
have
been
made,
there
is
critical
need
connect
dots
between
laboratory
hospital
better
lung
cancer
treatment.
Systemic
therapy
plays
crucial
role
treating
advanced-stage
recent
efforts
focused
on
developing
innovative
drug
delivery
techniques.
Nanoparticles
(NPs)
emerged
as
promising
approach
treatment,
offering
enhanced
delivery,
active
targeting,
reduced
toxicity.
Organic-based
nanomaterials,
like
polymeric
nanoparticles,
solid
lipid
liposomes
hold
great
potential
this
field.
This
review
examines
application
of
NPs
highlights
current
therapies,
explores
organic
nanoparticle-based
approaches,
discusses
limitations
future
perspectives
clinical
translation.
Exploration,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 15, 2024
Cancer
immunotherapy
is
the
most
promising
method
for
tumor
therapy,
while
ferroptosis
could
activate
immunogenicity
of
cancer
and
strengthen
cellular
immune
response.
However,
limited
by
complex
microenvironment,
abundant
glutathione
(GSH)
low
reactive
oxygen
species
(ROS)
seriously
weaken
Herein,
authors
report
photothermal
metal-phenolic
networks
(MPNs)
supplied
with
buthionine
sulfoximine
(BSO)
reducing
levels
GSH
then
trapping
cells
in
cascade
loop
to
eliminate
colorectal
(CRC).
The
MPNs
coated
model
antigen
ovalbumin
can
accumulate
at
site,
mediate
immunogenic
cell
death
(ICD)
under
NIR
irradiation,
initiate
tumoricidal
immunity.
Then
activated
CD8+
T
would
release
IFN-γ
inhibit
GPX4
promote
induced
Fe3+
BSO.
Finally,
intertumoral
intratumoral
be
involved
ferroptosis-dominated
cancer-immunity
circle
CRC
eradication,
resulting
outstanding
therapeutic
outcomes
both
primary
distant
models.
Overall,
this
strategy
employs
a
nanoplatform
rapidly
stimulate
ICD
restrain
oxidation
defense
system,
which
provides
approach
significantly
amplify
"cascade
loop"
induction
treatment
CRC.
