Engineering cell-derived extracellular matrix for peripheral nerve regeneration

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101125 - 101125

Published: June 13, 2024

Extracellular matrices (ECMs) play a key role in nerve repair and are recognized as the natural source of biomaterials. In parallel to extensively studied tissue-derived ECMs (ts-ECMs), cell-derived (cd-ECMs) also have capability partially recapitulate complicated regenerative microenvironment native tissues. Notably, cd-ECMs can avoid shortcomings ts-ECMs. Cd-ECMs be prepared by culturing various cells or even autologous vitro under pathogen-free conditions. And mild decellularization achieve efficient removal immunogenic components cd-ECMs. Moreover, more readily customizable desired functional properties. These advantages garnered significant attention for potential neuroregenerative medicine. As promising biomaterials, bring new hope effective treatment peripheral injuries. Herein, this review comprehensively examines current knowledge about characteristics their mechanisms interaction with regeneration, particular focus on preparation, engineering optimization, scalability The applications from distinct cell sources reported tissue highlighted summarized. Furthermore, limitations that should addressed outlooks related clinical translation put forward well.

Language: Английский

---

The considerations on selecting the appropriate decellularized ECM for specific regeneration demands

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101301 - 101301

Published: Oct. 18, 2024

Language: Английский

---

Astragaloside IV Improves Muscle Atrophy by Modulating the Activity of UPS and ALP via Suppressing Oxidative Stress and Inflammation in Denervated Mice

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Language: Английский

---

Shell-core-structured electrospinning film with sequential anti-inflammatory and pro-neurogenic effects for peripheral nerve repairment

Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Inducing an anti-inflammatory response before neurogenesis is crucial in effectively addressing peripheral nerve damage. Herein, we developed shell-core-structured nanofilms (Cur/PLCL@BDNF/CNT) using poly-( l -Lactide)-Caprolactone (PLCL) and curcumin (Cur, agent) as the shell layer, carbon nanotubes (CNT) brain-derived neurotrophic factor (BDNF, a neurogenic factor) core via coaxial electrospinning technology. The resulting Cur/PLCL@BDNF/CNT film exhibited characteristic fibrous structure with remarkable shell-core architecture, demonstrating unweakened mechanical properties. Notably, it displayed sustained release kinetics distinct stages: prioritized Cur within initial 12 days delayed BDNF between 10 to 30 days. Additionally, demonstrated high biocompatibility Schwann cells. Subsequent vitro analysis revealed potent capabilities of released from while layer induced differentiation was rolled into conduit then utilized for regeneration mm rat sciatic defect model. staged facilitated by established microenvironment initiating regeneration, better restoration. This study emphasizes significance temporally regulating anti-inflammation neurogenesis.

Language: Английский

---

Characterization of lncRNA and mRNA profiles in the process of repairing peripheral nerve defects with cell-matrixed nerve grafts

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Sept. 29, 2024

Language: Английский

---

Unveiling the molecular blueprint of SKP-SCs-mediated tissue engineering-enhanced neuroregeneration

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 26, 2024

Language: Английский

---

3D biological scaffold delivers Bergenin to reduce neuroinflammation in rats with cerebral hemorrhage

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 17, 2024

Intracerebral hemorrhage (ICH) is a severe form of stroke characterized by high incidence and mortality rates. Currently, there significant lack effective treatments aimed at improving clinical outcomes. Our research team has developed three-dimensional (3D) biological scaffold that incorporates Bergenin, allowing for the sustained release compound.

Language: Английский

---

Mesenchymal stem cell-derived exosomes in renal ischemia–reperfusion injury: a new therapeutic strategy

International Urology and Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Language: Английский

---

Advancements In Microsurgical Techniques for Hand Trauma: A Comprehensive Review

Anaesthesia & Surgery Open Access Journal, Journal Year: 2024, Volume and Issue: 5(1)

Published: July 8, 2024

Objective: This review meticulously navigates the dynamic landscape of microsurgery for hand trauma, exploring interplay between microsurgical techniques, nerve repair strategies, and contemporary approaches to managing open fractures soft tissue injuries.

Language: Английский

---