Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(34)
Published: June 19, 2021
Abstract
Active
tumor
penetration
has
been
recently
recognized
as
a
promising
strategy
to
resolve
the
limitation
of
nanomedicine
in
terms
penetration,
but
it
is
challenging
develop
active
transporting
nanocarriers.
Here,
an
ultrasonic
cavitation‐assisted
and
acid‐activatable
liposome
for
broad
range
tumors
reported.
The
(size
charge
dual‐conversional
gemcitabine
prodrug‐integrated
liposomal
nanodroplet
(SCGLN))
overcomes
tight
blood
vessel
walls
with
aid
cavitation.
SCGLN
subsequently
transforms
from
micro‐size
nano‐size
under
prolonged
ultrasound
radiation.
Once
acidic
microenvironment,
nanosized
undergoes
negative‐to‐positive
charge‐reversal
triggers
cationization‐initiated
transcytosis
penetrate
deep
into
parenchyma.
gemcitabine‐loaded
exhibits
potent
antitumor
activity
multiple
poorly
permeable
models,
which
completely
erases
subcutaneous
U251
glioma
stops
progression
orthotopic
BxPC3
pancreatic
ductal
adenocarcinoma.
This
study
presents
universal
penetrating
nanomedicines
efficient
drug
delivery
low
tumor.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(3), P. 574 - 574
Published: Jan. 31, 2023
The
human
nature
of
curiosity,
wonder,
and
ingenuity
date
back
to
the
age
humankind.
In
parallel
with
our
history
civilization,
interest
in
scientific
approaches
unravel
mechanisms
underlying
natural
phenomena
has
been
developing.
Recent
years
have
witnessed
unprecedented
growth
research
area
pharmaceuticals
medicine.
optimism
that
nanotechnology
(NT)
applied
medicine
drugs
is
taking
serious
steps
bring
about
significant
advances
diagnosing,
treating,
preventing
disease-a
shift
from
fantasy
reality.
growing
future
medical
applications
NT
leads
emergence
a
new
field
for
nanomaterials
(NMs)
biomedicine.
recent
years,
NMs
emerged
as
essential
game
players
modern
medicine,
clinical
ranging
contrast
agents
imaging
carriers
drug
gene
delivery
into
tumors.
Indeed,
there
are
instances
where
nanoparticles
(NPs)
enable
analyses
therapies
cannot
be
performed
otherwise.
However,
NPs
also
unique
environmental
societal
challenges,
particularly
concerning
toxicity.
Thus,
should
revisited,
deep
understanding
effects
pathophysiologic
basis
disease
may
more
sophisticated
diagnostic
opportunities
yield
effective
preventive
features.
Correspondingly,
this
review
highlights
contributions
systems.
This
study
attempted
glimpse
impact
pharmaceuticals.
International Journal of Nanomedicine,
Journal Year:
2020,
Volume and Issue:
Volume 15, P. 9355 - 9371
Published: Nov. 1, 2020
Abstract:
Exosomes
or
small
extracellular
vesicles
are
considered
a
new
generation
of
bioinspired-nanoscale
drug
delivery
system
(DDS).
Endogenous
exosomes
function
as
signalosomes
since
they
convey
signals
via
ligands
adhesion
molecules
located
on
the
exosomal
membrane,
packaged
inside
exosome.
Recently,
exosome
membrane
modification,
therapeutic
payloads
encapsulation,
and
modulation
in
vivo
disposition
have
been
extensively
investigated,
among
which
significant
advances
made
to
optimize
exosome-mediated
solid
tumors.
Exosomes,
specifically
tumor
cell-derived
exosomes,
presumed
tumor-preferential
due
homotypic
features.
However,
quality
attributes
that
dictate
tissue
distribution,
cell
type-selective
uptake,
intracellular
payload
release
administered
well
spatiotemporal
information
regarding
fate
vivo,
remain
be
further
investigated.
This
review
summarizes
recent
developing
platforms
with
focus
targeting.
The
pharmacokinetic
features
naive
factors
influencing
their
summarized.
Recent
strategies
improve
targeting
also
reviewed
context
biological
microenvironment
(TME).
Selected
approaches
augment
deposition
methods
enhance
delivery,
summarized
emphasis
underlying
mechanisms
(eg,
passive
active
targeting,
endosomal
escape,
etc.).
In
conclusion,
this
highlights
recently
reported
tumor-targeting
exosome-based
it's
hope
multiple
might
employed
synergistic
combination
development
cancer
therapy.
Keywords:
exosome,
tumor-targeting,
PK,
nanovesicles
Acta Pharmaceutica Sinica B,
Journal Year:
2022,
Volume and Issue:
12(7), P. 3028 - 3048
Published: March 1, 2022
Compared
with
traditional
drug
therapy,
nanomedicines
exhibit
intriguing
biological
features
to
increase
therapeutic
efficiency,
reduce
toxicity
and
achieve
targeting
delivery.
This
review
provides
a
snapshot
of
that
have
been
currently
launched
or
in
the
clinical
trials,
which
manifests
diversified
trend
carrier
types,
applied
indications
mechanisms
action.
From
perspective
indications,
this
article
presents
an
overview
applications
involving
prevention,
diagnosis
treatment
various
diseases,
include
cancer,
infections,
blood
disorders,
cardiovascular
immuno-associated
diseases
nervous
system
etc.
Moreover,
some
considerations
perspectives
research
development
facilitate
their
translations
clinic.
Molecular Therapy — Methods & Clinical Development,
Journal Year:
2020,
Volume and Issue:
18, P. 751 - 764
Published: July 31, 2020
Cationic
liposomes
(CLs)
have
been
regarded
as
the
most
promising
gene
delivery
vectors
for
decades
with
advantages
of
excellent
biodegradability,
biocompatibility,
and
high
nucleic
acid
encapsulation
efficiency.
However,
clinical
use
CLs
in
cancer
therapy
is
limited
because
many
uncertain
factors
Small,
Journal Year:
2022,
Volume and Issue:
18(16)
Published: Jan. 27, 2022
Abstract
Ultrasmall
nanoparticles
are
often
grouped
under
the
broad
umbrella
term
of
“nanoparticles”
when
reported
in
literature.
However,
for
biomedical
applications,
their
small
sizes
give
them
intimate
interactions
with
biological
species
and
endow
unique
functional
physiochemical
properties.
Carbon
quantum
dots
(CQDs)
an
emerging
class
ultrasmall
which
have
demonstrated
considerable
biocompatibility
been
employed
as
potent
theragnostic
platforms.
These
particles
find
application
increasing
drug
solubility
targeting,
along
facilitating
passage
drugs
across
impermeable
membranes
(i.e.,
blood
brain
barrier).
Further
functionality
can
be
triggered
by
various
environmental
conditions
or
external
stimuli
pH,
temperature,
near
Infrared
(NIR)
light,
ultrasound),
intrinsic
fluorescence
is
valuable
diagnostic
applications.
The
focus
this
review
to
shed
light
on
therapeutic
potential
CQDs
identify
how
they
travel
through
body,
reach
site
action,
administer
effect,
excreted.
Investigation
into
toxicity
compatibility
larger
nanoparticle
carriers
also
examined.
future
applications
promising
due
multifunctional
attributes
documented
biocompatibility.
As
nanomaterial
platforms
become
more
commonplace
clinical
treatments,
commercialization
CQD
therapeutics
anticipated.
