Frontiers in Nanotechnology,
Journal Year:
2024,
Volume and Issue:
6
Published: Oct. 11, 2024
Nanoparticulate
delivery
systems
have
been
attracting
attention
in
pharmaceutical
sciences
for
enhanced
drug
bioavailability
and
targeted
delivery.
Specifically,
these
can
enhance
the
solubility
of
poorly
water-soluble
drugs,
protect
therapeutic
agents
from
degradation,
prolong
circulation
time
body,
control
release,
facilitate
precise
targeting
drugs
to
specific
tissues
or
cells.
However,
once
administered
into
nanoparticles
often
encounter
significant
challenges
that
affect
their
efficacy
safety,
such
as
issues
with
stability,
biocompatibility,
targeting.
The
surface
properties
are
one
most
important
features
they
greatly
influence
interactions
between
themselves
biological
targets.
Key
characteristics,
charge,
hydrophobicity,
presence
functional
groups,
determine
how
behave
environments,
thereby
influencing
cellular
uptake,
ability
avoid
immune
clearance.
Modification
nanoparticle
has
shown
be
an
effective
approach
modulate
physicochemical
nanoparticles,
achieving
desired
vivo
.
This
review
aims
summarize
recent
advances
decoration
emphasis
on
improved
colloidal
reduced
toxicity,
future
perspectives
modification
approaches
also
discussed.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(21), P. 20825 - 20849
Published: Nov. 3, 2023
Understanding
the
in
vivo
transport
of
nanoparticles
provides
guidelines
for
designing
nanomedicines
with
higher
efficacy
and
fewer
side
effects.
Among
many
factors,
size
plays
a
key
role
controlling
their
behaviors
due
to
existence
various
physiological
thresholds
within
body
size-dependent
nano-bio
interactions.
Encouraged
by
evolving
discoveries
nanoparticle-size-dependent
biological
effects,
we
believe
that
it
is
necessary
systematically
summarize
size-scaling
laws
nanoparticle
vivo.
In
this
review,
summarized
effect
on
along
journey
body:
begin
administration
via
different
delivery
routes,
followed
targeting
intended
tissues
including
tumors
other
organs,
eventually
clearance
through
liver
or
kidneys.
We
outlined
tools
investigating
as
well.
Finally,
discussed
how
may
leverage
tackle
some
challenges
nanomedicine
translation
also
raised
important
size-related
questions
remain
be
answered
future.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(18), P. 10920 - 10989
Published: Sept. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
206, P. 115178 - 115178
Published: Jan. 8, 2024
Ultrasound-responsive
agents
have
shown
great
potential
as
targeted
drug
delivery
agents,
effectively
augmenting
cell
permeability
and
facilitating
absorption.
This
review
focuses
on
two
specific
microbubbles
nanodroplets,
provides
a
sequential
overview
of
their
process.
Particular
emphasis
is
given
to
the
mechanical
response
under
ultrasound,
subsequent
physical
biological
effects
cells.
Finally,
state-of-the-art
in
pre-clinical
clinical
implementation
are
discussed.
Throughout
review,
major
challenges
that
need
be
overcome
order
accelerate
translation
highlighted.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(17), P. 10979 - 11024
Published: April 18, 2024
Nanomaterials
have
attractive
physicochemical
properties.
A
variety
of
nanomaterials
such
as
inorganic,
lipid,
polymers,
and
protein
nanoparticles
been
widely
developed
for
nanomedicine
via
chemical
conjugation
or
physical
encapsulation
bioactive
molecules.
Superior
to
traditional
drugs,
nanomedicines
offer
high
biocompatibility,
good
water
solubility,
long
blood
circulation
times,
tumor-targeting
Capitalizing
on
this,
several
nanoformulations
already
clinically
approved
many
others
are
currently
being
studied
in
clinical
trials.
Despite
their
undoubtful
success,
the
molecular
mechanism
action
vast
majority
remains
poorly
understood.
To
tackle
this
limitation,
herein,
review
critically
discusses
strategy
applying
multiomics
analysis
study
nanomedicines,
named
nanomedomics,
including
advantages,
applications,
future
directions.
comprehensive
understanding
could
provide
valuable
insight
therefore
foster
development
translation
nanomedicines.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Drug Delivery and Translational Research,
Journal Year:
2024,
Volume and Issue:
14(10), P. 2845 - 2916
Published: July 13, 2024
Abstract
Several
efforts
have
been
extensively
accomplished
for
the
amelioration
of
cancer
treatments
using
different
types
new
drugs
and
less
invasives
therapies
in
comparison
with
traditional
therapeutic
modalities,
which
are
widely
associated
numerous
drawbacks,
such
as
drug
resistance,
non-selectivity
high
costs,
restraining
their
clinical
response.
The
application
natural
compounds
prevention
treatment
cells
has
attracted
significant
attention
from
pharmaceuticals
scientific
communities
over
past
decades.
Although
use
nanotechnology
therapy
is
still
preliminary
stages,
nanotherapeutics
demonstrated
to
decrease
various
limitations
related
compounds,
physical/chemical
instability,
poor
aqueous
solubility,
low
bioavailability.
Despite
emerged
a
promise
improve
bioavailability
there
limited
trials
performed
challenges
required
pre-clinical
trials,
production
at
an
industrial
level,
assurance
long-term
stability,
physiological
barriers
safety
regulatory
issues.
This
review
highlights
most
recent
advances
nanocarriers
secreted
plants,
bacteria,
fungi,
marine
organisms,
well
role
on
cell
signaling
pathways
anticancer
treatments.
Additionally,
status
main
regarding
loaded
applications
were
also
discussed.
Graphical
abstract
