Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(16), P. 10135 - 10155

Published: Aug. 3, 2023

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as inducers has not yet presented. In this review, we systematically summarize works PSs that induce different types RCD, including ferroptosis, immunogenic (ICD), pyroptosis. The characteristics mechanisms each explained. At end section, reported commonalities between inducing same is emphasized, future perspectives novel discussed at review. Considering essential roles in therapy, hope review will provide stage for advances inducers.

Language: Английский

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Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 66 - 97

Published: Sept. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Language: Английский

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Multi‐Bioinspired MOF Delivery Systems from Microfluidics for Tumor Multimodal Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(33)

Published: Oct. 18, 2023

Metal-organic framework (MOF)-based drug delivery systems have demonstrated values in oncotherapy. Current research endeavors are centralized on the functionality enrichment of featured MOF materials with designed versatility for synergistic multimodal treatments. Here, inspired by multifarious biological functions including ferroptosis pattern, porphyrins, and cancer cell membrane (CCM) camouflage technique, novel multi-biomimetic nanocarriers from microfluidics prepared. The Fe

Language: Английский

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Biomedical application of metal-organic frameworks (MOFs) in cancer therapy: Stimuli-responsive and biomimetic nanocomposites in targeted delivery, phototherapy and diagnosis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129391 - 129391

Published: Jan. 20, 2024

Language: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

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Tumor microenvironment targeting for glioblastoma multiforme treatment via hybrid cell membrane coating supramolecular micelles

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 194 - 203

Published: Jan. 3, 2024

Language: Английский

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Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Topical drug delivery is widely used in various diseases because of the advantages not passing through gastrointestinal tract, avoiding irritation and hepatic first-pass effect, reaching lesion directly to reduce unnecessary adverse reactions. The skin helps organism defend itself against a huge majority external aggressions one most important lines defense body. However, skin’s strong barrier ability also obstacle effectiveness topical medications. Allowing bioactive, composition pass stratum corneum as needed reach target site essential need for exert its therapeutic effect. state barrier, choice system composition, individualized disease detection dosing planning influence Nowadays, enhancing transdermal absorption topically applied drugs hottest research area. first improve all drugs. Excessive enhances accumulation at non-target sites occurrence This paper introduces strategies from three perspectives: delivery, describes current status shortcomings research, provides new directions ideas research.

Language: Английский

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ROS-responsive and triple-synergistic mitochondria-targeted polymer micelles for efficient induction of ICD in tumor therapeutics

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 490 - 507

Published: June 1, 2024

Immunogenic cell death (ICD) represents a modality of apoptosis distinguished by the emanation an array damage-related molecular signals. This mechanism introduces novel concept in field contemporary tumor immunotherapy. The inception reactive oxygen species (ROS) within cells stands as essential prerequisite and foundation for ICD induction. formulation highly efficacious photodynamic therapy (PDT) nanomedicines successful induction is area significant scientific inquiry. In this work, we devised ROS-responsive triple-synergistic mitochondria-targeted polymer micelle (CAT/CPT-TPP/PEG-Ce6, CTC) that operates with multistage amplification ROS to achieve potent ICD. Utilizing "all-in-one" strategy, direct both PDT chemotherapeutic units mitochondria. Concurrently, cyclical caused triple synergy strategy stimulates continuous, stable, adequate generation (domino effect) mitochondria cells. Conclusively, influenced ROS, cell-induced effectively activated, remodeling immunogenicity, enhancing therapeutic impact when synergized chemotherapy. Empirical evidence from vitro study substantiates CTC micelles can efficiently provoke ICD, catalyzing CRT translocation, liberation HMGB1 ATP. Furthermore, animal trials corroborate micelles, following tail vein injection, induce accumulate tissues, markedly inhibit growth subsequent laser irradiation. Finally, transcriptome analysis was carried out evaluate changes genome induced micelles. work demonstrates improve combination immunotherapy using nanotechnology.

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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