Small Methods,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Oct. 17, 2023
Abstract
Despite
the
tremendous
progress
in
cancer
treatment
recent
decades,
cancers
often
become
resistant
due
to
multiple
mechanisms,
such
as
intrinsic
or
acquired
multidrug
resistance,
which
leads
unsatisfactory
effects
accompanying
metastasis
and
recurrence,
ultimately
failure.
With
a
deeper
understanding
of
molecular
mechanisms
tumors,
researchers
have
realized
that
designs
targeting
tumor
resistance
would
be
promising
strategy
break
therapeutic
deadlock.
Nanodelivery
systems
excellent
physicochemical
properties,
including
highly
efficient
tissue‐specific
delivery,
substantial
specific
surface
area,
controllable
chemistry,
endow
nanodelivery
with
capabilities
precise
targeting,
deep
penetration,
responsive
drug
release,
codelivery,
multimodal
synergy,
are
currently
widely
used
biomedical
researches
bring
new
dawn
for
overcoming
resistance.
Based
on
this
review
summarizes
research
improve
efficacy
years
offers
prospects
challenges
application
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(1)
Published: Sept. 15, 2023
Abstract
The
therapeutic
application
of
STING
agonists
in
various
malignancies
has
been
limited
by
factors
such
as
the
inability
systemic
administration
and
immunosuppressive
tumor
microenvironment.
Herein,
this
work
reports
a
mesoporous
polydopamine‐based
multifunctional
nanoplatform
loaded
with
agonist
MSA‐2
chelated
Mn
2+
for
synergistic
photothermal
activation‐based
immunotherapy.
effectively
delivers
to
site
intelligently
releases
its
contents
through
acid
degradation,
facilitated
effect.
Additionally,
thermal
ablation
tissue
can
induce
immunogenic
cell
death,
which
helps
alleviate
microenvironment,
thereby
enhancing
efficacy
MSA‐2.
Furthermore,
works
dual‐acting
sensitizer
MRI
contrast
agent
not
only
boosts
immune
response
but
also
allows
real‐time
tracking
nanoplatform.
This
strategy
is
proved
highly
efficacious
both
impeding
primary/metastatic
eliciting
robust
tumor‐specific
response.
Collectively,
an
effective
delivery
synergized
therapy
pathway
activation‐mediated
immunotherapy
highlighted
here
provide
new
ideas
strategies
optimizing
combination
cancer
treatment.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2650 - 2669
Published: Jan. 1, 2024
Combining
phototherapies,
particularly
PDT
and
PTT,
with
immunotherapy
synergistically
stimulates
immune
responses,
offering
promising
strategies
for
effective
cancer
treatment
prevention
of
recurrence.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
651, P. 123763 - 123763
Published: Jan. 2, 2024
Nanomaterials'
application
in
cancer
therapy
has
been
driven
by
their
ability
to
encapsulate
chemotherapeutic
drugs
as
well
reach
the
tumor
site.
Nevertheless,
nanomedicines'
translation
limited
due
lack
of
specificity
towards
cells.
Although
nanomaterials'
surface
can
be
coated
with
targeting
ligands,
such
mostly
achieved
through
non-covalent
functionalization
strategies
that
are
prone
premature
detachment.
Notwithstanding,
cells
often
establish
resistance
mechanisms
impair
effect
loaded
drugs.
This
bottleneck
may
addressed
using
near-infrared
(NIR)-light
responsive
nanomaterials.
The
NIR-light
triggered
hyperthermic
generated
these
nanomaterials
cause
irreversible
damage
or
sensitize
them
chemotherapeutics'
action.
Herein,
a
novel
covalently
functionalized
targeted
NIR-absorbing
nanomaterial
for
chemo-photothermal
was
developed.
For
such,
dopamine-reduced
graphene
oxide
were
bonded
hyaluronic
acid,
and
then
doxorubicin
(DOX/HA-DOPA-rGO).
produced
showed
suitable
physicochemical
properties,
high
encapsulation
efficiency,
photothermal
capacity.
vitro
studies
revealed
cytocompatible
display
an
improved
uptake
CD44-overexpressing
breast
Importantly,
combination
DOX/HA-DOPA-rGO
NIR
light
reduced
cells'
viability
just
23
%,
showcasing
potential
therapy.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(18), P. 4275 - 4310
Published: Jan. 1, 2024
This
comprehensive
review
systematically
summarizes
the
intrinsic
mechanism
of
different
metal
ion
(such
as
Fe
3+
/Fe
2+
,
Cu
/Cu
+
Ca
Zn
Mn
Na
/K
and
Mg
)-mediated
interference
therapies
their
research
progress
in
cancer
treatment.
