Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 133, P. 110985 - 110985

Published: Nov. 16, 2020

Gallic acid (GA), also known as 3,4,5-trihydroxybenzoic acid, is a natural secondary metabolite and widely isolated from various fruits, plants nuts. In recent years, GA has received increasing attention for its powerful anti-inflammatory properties. The purpose of this review to clearly illuminate the pharmacological activities related molecular mechanisms in inflammatory diseases. After consulting large number literatures, we made comprehensive exposition on chemical characteristics, plant origins, pharmacokinetics toxicity GA, especially action. Although source very rich, lower extraction rate limits application development. It worth mentioning that can not only be separated many plants, but produced quantities through biological synthesis. According pharmacokinetic studies, absorption elimination after oral administration are fast, while structural optimization or dosage form adjustment beneficial increase bioavailability. Promisingly, studies have shown scarcely obvious side effects variety animal experiments clinical trials. results show mainly involved MAPK NF-κB signaling pathways. thus weakens response by reducing release cytokines, chemokines, adhesion molecule cell infiltration. Due excellent activities, expected potential candidate treatment inflammation-related This paper will provide theoretical basis guide future research medicinal development GA.

Language: Английский

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Depression and Its Phytopharmacotherapy—A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4772 - 4772

Published: March 1, 2023

Depression is a mental health disorder that develops as result of complex psycho-neuro-immuno-endocrinological disturbances. This disease presents with mood disturbances, persistent sadness, loss interest and impaired cognition, which causes distress to the patient significantly affects ability function have satisfying family, social professional life. requires comprehensive management, including pharmacological treatment. Because pharmacotherapy depression long-term process associated risk numerous adverse drug effects, much attention paid alternative therapy methods, phytopharmacotherapy, especially in treating mild or moderate depression. Preclinical studies previous clinical confirm antidepressant activity active compounds plants, such St. John’s wort, saffron crocus, lemon balm lavender, less known European ethnopharmacology, roseroot, ginkgo, Korean ginseng, borage, brahmi, mimosa tree magnolia bark. The these plants exert antidepressive effects similar mechanisms those found synthetic antidepressants. description phytopharmacodynamics includes inhibiting monoamine reuptake oxidase complex, agonistic antagonistic on multiple central nervous system (CNS) receptors. Moreover, it noteworthy anti-inflammatory effect also important mentioned above light hypothesis immunological disorders CNS are significant pathogenetic factor narrative review results from traditional, non-systematic literature review. It briefly discusses pathophysiology, symptomatology treatment depression, particular focus role phytopharmacology its provides action revealed experimental ingredients isolated herbal antidepressants selected confirming their effectiveness.

Language: Английский

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Botanical drugs and supplements affecting the immune response in the time of COVID‐19: Implications for research and clinical practice

Phytotherapy Research, Journal Year: 2020, Volume and Issue: 35(6), P. 3013 - 3031

Published: Dec. 29, 2020

In times of health crisis, including the current COVID-19 pandemic, potential benefit botanical drugs and supplements emerges as a focus attention, although controversial efficacy claims are rightly concern. Phytotherapy has an established role in everyday self-care care, but, since preparations contain many chemical constituents rather than single compounds, challenges arise demonstrating safety. However, there is ample traditional, empirical, clinical evidence that botanicals can offer some protection alleviation disease symptoms well promoting general well-being. Newly emerging viral infections, specifically COVID-19, represent unique challenge their novelty absence antiviral treatment or immunization. We discuss here roles limitations phytotherapy helping to prevent address especially regarding effects on immune response. Botanicals with documented immunomodulatory, immunostimulatory, antiinflammatory include adaptogens, Boswellia spp., Curcuma longa, Echinacea Glycyrrhiza medicinal fungi, Pelargonium sidoides, salicylate-yielding herbs, Sambucus spp. further provide perspective applications safety these herbs prevention, onset, progression, convalescence from respiratory infections.

Language: Английский

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Plant Adaptogens—History and Future Perspectives

Nutrients, Journal Year: 2021, Volume and Issue: 13(8), P. 2861 - 2861

Published: Aug. 20, 2021

Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance body’s stability against physical loads without increasing oxygen consumption. Extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis considered be naturally occurring adaptogens and, in particular, adaptogens. The aim of this study is evaluate use past now, as well outline prospects their future applications. natural by humans has a rich history—they used recovery illness, weakness, memory impairment, other conditions. About 50 years ago, were first professional sports due high potential increase resistance stress improve endurance. Although now many people take adaptogens, clinical trials on human limited. data meta-analysis showed could provide number benefits treatment chronic fatigue, cognitive immune protection. In future, there great register medicinal products contain for therapeutic purposes.

Language: Английский

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Pharmacological effects of salidroside on central nervous system diseases

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 156, P. 113746 - 113746

Published: Oct. 10, 2022

Language: Английский

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Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12293 - 12293

Published: July 31, 2023

The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, Siberia, have been used since ancient times to alleviate stress, fatigue, mental physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, rosin, tyrosol glucoside salidroside, tyrosol, are responsible for the biological action R. rosea, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. extract formulations as alternative remedies enhance cognitive functions protect central nervous system heart during stress. Recent studies indicate that may be treat diabetes, cancer, a variety cardiovascular neurological disorders such Alzheimer's Parkinson's diseases. This paper reviews beneficial effects its key active components, their possible use treatment chronic represents an excellent natural remedy address situations involving decreased performance, fatigue sense weakness, particularly context Given significance mitochondria cellular energy metabolism vulnerability reactive oxygen species, future research should prioritize investigating potential main bioactive phenolic compounds on mitochondria, thus targeting supply countering oxidative stress-related effects.

Language: Английский

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Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 121, P. 110397 - 110397

Published: June 10, 2023

Dry eye disease (DED) is a multifactorial disease, and oxidative stress plays crucial role in its pathogenesis. Recently, multiple studies have shown that upregulation of autophagy can protect the cornea from damage. The present study investigated therapeutic effects salidroside, main component Rhodiola crenulata, both vivo vitro dry models. results showed topical drop treatment with salidroside restored corneal epithelium damage, increased tear secretion, reduced inflammation DED mice. Salidroside activated through AMP-activated protein kinase (AMPK)-sirtuin-1 (Sirt1) signaling pathway, which promoted nuclear translocation factor erythroid-2-related 2 (Nrf2) expression downstream antioxidant factors heme oxygenase-1 (HO-1) NAD(P)H quinone dehydrogenase 1 (NQO1). This process enzyme activity, reactive oxygen species (ROS) accumulation, alleviated stress. application inhibitor chloroquine AMPK Compound C reversed efficacy validating above findings. In conclusion, our data suggest promising candidate for treatment.

Language: Английский

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Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 115, P. 109731 - 109731

Published: Jan. 20, 2023

Language: Английский

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Biomimetic tri-layered small-diameter vascular grafts with decellularized extracellular matrix promoting vascular regeneration and inhibiting thrombosis with the salidroside

Materials Today Bio, Journal Year: 2023, Volume and Issue: 21, P. 100709 - 100709

Published: July 1, 2023

Small-diameter vascular grafts (SDVGs) are urgently required for clinical applications. Constructing mimicking the defining features of native arteries is a promising strategy. Here, we constructed tri-layered graft with artery decellularized extracellular matrix (dECM) component arteries. The porcine thoracic aorta was and milled into dECM powders from differential layers. intima media were blended poly (L-lactide-co-caprolactone) (PLCL) as inner middle layers electrospun grafts, respectively. Pure PLCL strengthening sheath outer layer. Salidroside loaded layer to inhibit thrombus formation. In vitro studies demonstrated that provided bioactive milieu human umbilical vein endothelial cell (HUVEC) extension adhesion, proliferation, migration, tube-forming. in vivo showed addition could promote endothelialization, smooth muscle regeneration, deposition. salidroside thrombosis. Our study mimicked combined it advantages synthetic polymer which strategy design construction SDVGs.

Language: Английский

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Pharmacological functions of salidroside in renal diseases: facts and perspectives

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, altitude sickness prevention properties. Salidroside, most active constituent derived from , exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role salidroside has burgeoned over last decade, making it beneficial option treatment multiple diseases, including atherosclerosis, Alzheimer’s disease, Parkinson’s cardiovascular more. With renoprotective effects, parallel with inhibition oxidative stress inflammation, holds promise as potential therapeutic agent kidney damage. This article provides an overview microinflammatory state disease discuss current strategies, particular focus on highlighting recent advancements utilizing renal disease. mechanisms action are primarily associated regulation gene protein expression glomerular endothelial cells, podocytes, tubule mesangial cells cell carcinoma cell, TNF-α, TGF-β, IL-1β, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1α, BIM, well modulation AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1α, ROS/Src/Cav-1, Akt/GSK-3β, TXNIP-NLRP3, ERK1/2, TGF-β1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a β-catenin, TLR4/NF-κB, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To best our knowledge, this review first to comprehensively cover protective diverse suggests great be developed drug metabolic syndrome, cerebrovascular diseases complications.

Language: Английский

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