The Microalgal Diatoxanthin Inflects the Cytokine Storm in SARS-CoV-2 Stimulated ACE2 Overexpressing Lung Cells DOI Creative Commons
Clementina Sansone, Luigi Pistelli, Angelo Del Mondo

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(8), P. 1515 - 1515

Published: Aug. 3, 2022

Contact between SARS-CoV-2 and human lung cells involves the viral spike protein angiotensin-converting enzyme 2 (ACE2) receptor on epithelial cells, latter being strongly involved in regulation of inflammation as well blood pressure homeostasis. infection is characterized by a strong inflammatory response defined "cytokine storm". Among recent therapeutic approaches against targeting dramatic reaction, some natural products are promising. Diatoms microalgae able to produce bioactive secondary metabolites, such xanthophyll diatoxanthin (Dt). The aim this study demonstrate anti-inflammatory effects Dt A549-hACE2 cell line, exploring its interaction with ACE2 receptor, depicting role inhibiting cytokine storm induced glycoprotein. Results showed that enhanced metabolism, e.g., percent metabolically active enzymatic activity. Moreover, affected glycoprotein-exposed decreasing interleukin-6 production increasing interleukin-10 release. upregulated genes encoding for interferon pathway related antiviral defense proteins belonging innate immunity response. potential interest new agent treatment and/or prevention severe syndrome postulated.

Language: Английский

Cytokine Storm Signature in Patients with Moderate and Severe COVID-19 DOI Open Access
Olga Kalinina, А. С. Головкин, Ekaterina Zaikova

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(16), P. 8879 - 8879

Published: Aug. 10, 2022

Hypercytokinemia, found in SARS-CoV-2 infection, contributes to multiple organ dysfunctions with acute respiratory distress syndrome, shock etc. The aim of this study was describe cytokine storm signatures patients COVID-19 and investigate their influence on severity the infection. Plasma levels 47 cytokines were investigated 73 moderate severe (41 32, respectively) 11 healthy donors (HD). most elevated comparing HD observed for seven pro-inflammatory (IL-6, IL-8, IL-15, IL-18, IL-27, IFNγ, TNFα), three chemokines (GROα, IP-10, MIG), two anti-inflammatory (IL-1RA, IL-10), growth factors (G-CSF, M-CSF). disease had significantly higher FGF-2/FGF-basic, IL-1β, IL-7 compared HD. groups differed from each other only based EGF, eotaxin, IL-12 p40. Pneumonia lung injury, characterized by computer tomography, positively correlated MCP-3 negatively Pro-inflammatory including IL-6, TNFα, IP-10 frequency circulating T-helper17-like cells (Th17-like) follicular Th that are crucial develop SARS-CoV-2-specific plasma memory B cells. Obtained data illustrate progression COVID-19.

Language: Английский

Citations

57
Inflammatory pathways in COVID‐19: Mechanism and therapeutic interventions DOI
Yujie Jiang, Tingmei Zhao, Xueyan Zhou

et al.

MedComm, Journal Year: 2022, Volume and Issue: 3(3)

Published: Aug. 1, 2022

The 2019 coronavirus disease (COVID-19) pandemic has become a global crisis. In the immunopathogenesis of COVID-19, SARS-CoV-2 infection induces an excessive inflammatory response in patients, causing cytokine storm severe cases. Cytokine leads to acute respiratory distress syndrome, pulmonary and other multiorgan failure, which is important cause COVID-19 progression even death. Among them, activation pathways major factor generating storms dysregulated immune responses, closely related severity viral infection. Therefore, elucidation signaling pathway providing otential therapeutic targets treatment strategies against COVID-19. Here, we discuss pathogenesis including induction, function, downstream signaling, as well existing potential interventions targeting these cytokines or pathways. We believe that comprehensive understanding regulatory dysregulation inflammation will help develop better clinical therapy effectively control diseases, such

Language: Английский

Citations

45
Checkpoint inhibitor/interleukin‐based combination therapy of cancer DOI Creative Commons
Keywan Mortezaee, Jamal Majidpoor

Cancer Medicine, Journal Year: 2022, Volume and Issue: 11(15), P. 2934 - 2943

Published: March 17, 2022

Immunotherapy using immune checkpoint inhibitors (ICIs) is the current focus in cancer immunotherapy. However, issues are raised area, as recent studies showed that such therapeutic modality suffers from low durability and or no efficacy for patients with some tumor types including cases non-inflamed cold cancers. Therefore, efforts have been made to solve issue combination therapy, use of immunocytokines. The ICI interleukins (ILs) IL-targeting agents now under consideration area primary results promising. this review discuss possibility ILs drugs immunotherapy describing advances field PEGylated fusion proteins. key reduce adverse events increase therapy.

Language: Английский

Citations

37
Roles for macrophage-polarizing interleukins in cancer immunity and immunotherapy DOI
Keywan Mortezaee, Jamal Majidpoor

Cellular Oncology, Journal Year: 2022, Volume and Issue: 45(3), P. 333 - 353

Published: May 19, 2022

Language: Английский

Citations

37
Epithelial-mesenchymal transition in cancer stemness and heterogeneity: updated DOI
Keywan Mortezaee, Jamal Majidpoor, Ebrahim Kharazinejad

et al.

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)

Published: Sept. 7, 2022

Language: Английский

Citations

28
Exploration of the anti-inflammatory mechanism of Lanqin oral solution based on the network pharmacology analysis optimized by Q-markers selection DOI
Hui Ma,

Weiliang Fu,

Hengyuan Yu

et al.

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 154, P. 106607 - 106607

Published: Jan. 23, 2023

Language: Английский

Citations

13
CD8+ T Cells in SARS-CoV-2 Induced Disease and Cancer—Clinical Perspectives DOI Creative Commons
Keywan Mortezaee, Jamal Majidpoor

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: April 1, 2022

Dysregulated innate and adaptive immunity is a sign of SARS-CoV-2-induced disease cancer. CD8 + T cells are important the immune system. The belong to take front-line defense against viral infections Extreme T-cell activities in lung patients with within tumor microenvironment (TME) will change their functionality into exhausted state undergo apoptosis. Such diminished put cancer cases at high-risk group for disease, rendering sepsis more severe condition which finally cause higher rate mortality. Recovering responses from purpose vaccination SARS-CoV-2. aim this review discuss cellular present some strategies recovering these critical cells.

Language: Английский

Citations

20
SARS-CoV-2 Infection and Preeclampsia—How an Infection Can Help Us to Know More about an Obstetric Condition DOI Creative Commons
Otilia Gonzalez, Óscar Martínez Pérez

Viruses, Journal Year: 2023, Volume and Issue: 15(7), P. 1564 - 1564

Published: July 17, 2023

Pregnant women with SARS-CoV-2 infection have a significantly higher risk of maternal death, ICU admission, preterm delivery, and stillbirth compared to those without infection. Additionally, the preeclampsia (PE) increases in pregnant infected SARS-CoV-2, particularly severe cases. The association between COVID-19 PE is likely attributed various mechanisms, including direct effects virus on trophoblast function arterial wall, exaggerated inflammatory response women, local inflammation leading placental ischemia, SARS-CoV-2-related myocardial injury, cytokine storm, thrombotic microangiopathy. This paper aims explore similarities infection, considering as valuable study model. By examining these parallels, we can enhance our knowledge comprehension PE. We wish emphasize potential for COVID-19-induced injury its connection increased mortality rate.

Language: Английский

Citations

12
Effects of Sulforaphane on SARS‑CoV‑2 infection and NF‑κB dependent expression of genes involved in the COVID‑19 ‘cytokine storm’ DOI Creative Commons
Jessica Gasparello, Giovanni Marzaro, Chiara Papi

et al.

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 52(3)

Published: July 14, 2023

Since its spread at the beginning of 2020, coronavirus disease 2019 (COVID‑19) pandemic represents one major health problems. Despite approval, testing, and worldwide distribution anti‑severe acute respiratory syndrome 2 (SARS‑CoV‑2) vaccines, development specific antiviral agents targeting SARS‑CoV‑2 life cycle with high efficiency, and/or interfering associated 'cytokine storm', is highly required. A recent study, conducted by authors' group indicated that sulforaphane (SFN) inhibits expression IL‑6 IL‑8 genes induced treatment IB3‑1 bronchial cells a recombinant spike protein SARS‑CoV‑2. In present ability SFN to inhibit replication pro‑inflammatory encoding proteins COVID‑19 storm' was evaluated. assessed in epithelial Calu‑3 cells. Moreover, evaluated reverse transcription quantitative droplet digital PCR. The effects on levels NF‑κB were western blotting. Molecular dynamics simulations NF‑kB/SFN interactions Gromacs 2021.1 software under Martini CG force field. Computational studies i) stably bound monomer; ii) ternary NF‑kB/SFN/DNA complex formed; iii) interacted both nucleic acid molecules modifying binding mode latter, impairing full interaction between DNA molecule. This finally stabilized inactive complex. demonstrated infected cells, decreasing production N‑protein coding RNA sequences, decreased content inhibited NF‑kB‑dependent IL‑1β gene expression. data obtained study inhibitory genes, sustaining possible use management patients COVID‑19.

Language: Английский

Citations

11
IL-6 and IL-17 as potential links between pre-existing hypertension and long-term COVID sequelae in patients undergoing hemodialysis: a multicenter cross-sectional study DOI Creative Commons
N. Stepanova,

V. Driianska,

Andriy Rysyev

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 29, 2024

Abstract Long COVID, characterized by persistent symptoms following acute infection, poses a significant health challenge, particularly for patients with pre-existing chronic conditions such as hypertension. We hypothesized that an increase in the production of interleukins (IL)-6 and IL-17 could serve potential mechanism linking uncontrolled blood pressure (BP) to occurrence long-term COVID sequelae undergoing hemodialysis (HD). This cross-sectional study examined serum IL-6 levels 80 HD, considering preinfection BP, presence sequelae, time interval after COVID-19 which was either 5 or 10 months. Controlled BP defined 3-month average pre-dialysis < 140/90 mmHg post-dialysis 130/80 mmHg. The findings suggest prevalence significantly higher than BP-controlled group. Both concentrations were also compared had values fully recovered at both points, but their decreased over time. Further research prospective studies are warranted validate these findings.

Language: Английский

Citations

4