Genes & Diseases,
Journal Year:
2023,
Volume and Issue:
11(4), P. 100987 - 100987
Published: June 22, 2023
Cancer
occurrence
and
development
are
closely
related
to
increased
lipid
production
glucose
consumption.
Lipids
the
basic
component
of
cell
membrane
play
a
significant
role
in
cancer
processes
such
as
cell-to-cell
recognition,
signal
transduction,
energy
supply,
which
vital
for
rapid
proliferation,
invasion,
metastasis.
Sterol
regulatory
element-binding
transcription
factor
1
(SREBP1)
is
key
regulating
expression
genes
cholesterol
biosynthesis,
homeostasis,
fatty
acid
synthesis.
In
addition,
SREBP1
its
upstream
or
downstream
target
implicated
various
metabolic
diseases,
particularly
cancer.
However,
no
review
biology
has
yet
been
published.
Herein,
we
summarized
roles
mechanisms
biological
cells,
including
modification,
metabolism
reprogramming,
mitochondrial
metabolism,
immunity,
tumor
microenvironment,
epithelial-mesenchymal
transition,
cycle,
apoptosis,
ferroptosis.
Additionally,
discussed
potential
prognosis,
drug
response
sensitivity
chemotherapy
radiotherapy,
drugs
targeting
corresponding
pathway,
elucidating
clinical
application
based
on
pathway.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(3)
Published: Dec. 2, 2023
Abstract
Due
to
the
specific
advantages
of
ultrasound
(US)
in
therapeutic
disease
treatments,
unique
US
technology
has
emerged.
In
addition
featuring
a
low‐invasive
targeted
cancer‐cell
killing
effect,
been
demonstrated
modulate
tumor
immune
landscape,
amplify
effect
other
antitumor
therapies,
and
induce
immunosensitization
tumors
immunotherapy,
shedding
new
light
on
cancer
treatment.
Tremendous
advances
nanotechnology
are
also
expected
bring
unprecedented
benefits
enhancing
efficiency
immunological
effects
US,
as
well
US‐derived
bimodal
multimodal
synergistic
therapies.
This
comprehensive
review
summarizes
induced
by
different
technologies,
including
ultrasound‐mediated
micro‐/nanobubble
destruction
(UTMD/UTND),
sonodynamic
therapy
(SDT),
focused
(FUS),
main
underlying
mechanisms
involved.
It
is
discussed
that
recent
research
progress
engineering
intelligent
nanoplatform
improving
technologies.
Finally,
focusing
clinical
translation,
key
issues
challenges
currently
faced
summarized,
prospects
for
promoting
translation
these
emerging
nanomaterials
ultrasonic
immunotherapy
future
proposed.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: March 27, 2023
This
study
aimed
to
investigate
the
structure
characterization
and
antiinflammatory
activity
of
a
novel
polysaccharide,
PKP2-1,
from
rhizomes
Polygonatum
kingianum
Coll.
Hemsl.We
isolated
Hemsl.
for
first
time,
which
was
then
successively
purified
through
hot-water
extraction,
80%
alcohol
precipitation,
anion
exchange
gel
permeation
chromatography.
The
in
vitro
anti-inflammatory
PKP2-1
MH7A
cells
assessed
using
CCK-8
kit
assay.Monosaccharide
composition
assay
revealed
that
mainly
composed
glucose,
galactose,
mannose,
glucuronic
acid
at
an
approximate
molar
ratio
6:2:2:1.
It
had
molecular
weight
approximately
17.34
kDa.
Structural
investigation
backbone
consisted
(→2,
3)-α-D-Galp(4→,
→2)-α-D-Manp(3→,
→2)-β-D-Glcp(4→)
α-D-Glcp(3→)
residues
with
side
chains
(→2)-β-D-Glcp(4→,
→1)-α-D-Galp(4→)
branches
located
O-3
position
3)-α-D-Galp(4→).
could
reduce
expression
IL-11β
IL-6,
increase
IL-10
induce
apoptosis
synovial
fibroblasts.The
inhibit
cell
growth
potentially
be
exploited
as
agent.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: July 17, 2023
Astragalus
membranaceus
(
A.
)
is
a
homologous
plant
with
high
medicinal
and
edible
value.
Therefore,
the
extraction
methods
of
polysaccharide
(APS)
have
attracted
attention
many
research
groups,
but
yield
active
components
still
not
high.
The
aim
this
study
was
to
extract
APS
by
semi-bionic
method,
optimize
process,
evaluate
anti-aging
activities
in
vivo
.
results
showed
that
18.23%
when
extracted
method.
Anti-aging
evaluation
rats
method
significantly
decreased
malondialdehyde
(MDA)
content
increased
superoxide
dismutase
(SOD)
activity
cope
D-galactose-induced
aging.
Serum
metabolomic
analysis
indicated
total
48
potential
biomarkers
significant
differences,
mainly
involving
5
metabolic
pathways.
These
altered
pathways
were
related
energy
metabolism,
amino
acid
lipid
metabolism.
can
effectively
improve
APS,
exhibited
rats.
Our
provided
novel
effective
be
used
as
functional
food
natural
medicine
delay
aging
prevent
its
complications.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 2, 2024
widely
used
in
traditional
Chinese
medicine,
exhibits
multiple
pharmacological
effects,
including
immune
stimulation,
antioxidation,
hepatoprotection,
diuresis,
antidiabetes,
anticancer,
and
expectorant
properties.
Its
main
bioactive
compounds
include
flavonoids,
triterpene
saponins,
polysaccharides.
Astragalus
polysaccharides
(APS),
one
of
its
primary
components,
have
been
shown
to
possess
a
variety
activities,
such
as
antioxidant,
immunomodulatory,
anti-inflammatory,
antitumor,
antidiabetic,
antiviral,
hepatoprotective,
anti-atherosclerotic,
hematopoietic,
neuroprotective
effects.
This
review
provides
comprehensive
summary
the
molecular
mechanisms
therapeutic
effects
APS
treating
neurodegenerative
diseases,
Alzheimer's
disease
(AD),
Parkinson's
(PD),
sclerosis
(MS).
It
discusses
how
improve
insulin
resistance,
reduce
blood
glucose
levels,
enhance
cognitive
function,
Aβ
accumulation
neuronal
apoptosis
by
modulating
various
pathways
Nrf2,
JAK/STAT,
Toll,
IMD.
For
PD,
protect
neurons
stabilize
mitochondrial
function
inhibiting
ROS
production
promoting
autophagy
through
PI3K/AKT/mTOR
pathway.
also
oxidative
stress
neurotoxicity
induced
6-hydroxydopamine,
showcasing
their
In
MS,
alleviate
symptoms
suppressing
T
cell
proliferation
reducing
pro-inflammatory
cytokine
expression
via
PD-1/PD-Ls
promote
myelin
regeneration
activating
Sonic
hedgehog
signaling
pathway
fostering
differentiation
neural
stem
cells
into
oligodendrocytes.
article
emphasizes
significant
activities
APS,
highlighting
potential
promising
candidates
for
treatment
diseases.
Carbohydrate Polymer Technologies and Applications,
Journal Year:
2024,
Volume and Issue:
7, P. 100526 - 100526
Published: June 1, 2024
Functional
polysaccharides
are
characterized
by
functional
and
structural
biomolecules,
which
play
a
dual
role,
both
as
nutrient
molecules
providing
energy
signalling
involved
in
intercellular
communications.
There
increasing
evidences
showing
that
possess
beneficial
effects
for
treating
chronic
diseases,
such
cancer,
cardiovascular
disease,
etc,
but
its
mechanism
of
action
remains
imprecision.
Additionally,
due
to
the
limitations
precision
detection
methods
complexity
their
structures,
metabolic
kinetics
behaviours
or
bioavailability
polysaccharides,
interaction
between
it
entering
systemic
circulation
target
cells
have
been
conundrum
faced
researcher.
This
review
summarized
latest
advances
efficacy
diseases
structure-activity
relationship,
absorption
behaviours,
specific
cellular
receptors
so
understand
mechanisms
bioactivities.
is
expected
provide
new
insights
paves
way
application.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 3, 2022
Fibrosis
is
the
abnormal
deposition
of
extracellular
matrix,
characterized
by
accumulation
collagen
and
other
matrix
components,
which
causes
organ
dysfunction
even
death.
Despite
advances
in
understanding
fibrosis
pathology
clinical
management,
there
no
treatment
for
that
can
prevent
or
reverse
it,
existing
options
may
lead
to
diarrhea,
nausea,
bleeding,
anorexia,
liver
toxicity.
Thus,
effective
drugs
are
needed
fibrotic
diseases.
Traditional
Chinese
medicine
has
played
a
vital
role
diseases,
accumulating
evidence
demonstrated
Astragalus
(
mongholicus
Bunge)
attenuate
multiple
include
fibrosis,
pulmonary
peritoneal
renal
cardiac
so
on,
mechanisms
be
related
inhibition
epithelial-mesenchymal
transition
(EMT),
reactive
oxygen
species
(ROS),
transforming
growth
factor
beta
1
(TGF-β1)/Smads,
apoptosis,
inflammation
pathways.
The
purpose
this
review
was
summarize
pharmacology
treating
data
reviewed
demonstrates
promising
anti-fibrotic
drug,
its
main
components
Calycosin,
Astragaloside
IV,
polysaccharides
formononetin.
We
also
formulas
contain
with
effects,
Salvia
miltiorrhiza
Bunge,
Angelica
sinensis
(Oliv.)
Diels
most
commonly
used
combinations.
propose
combining
active
into
new
formulations
way
develop
fibrosis.
Besides,
we
expect
accepted
as
clinically
method
Pharmacological Research,
Journal Year:
2023,
Volume and Issue:
199, P. 107034 - 107034
Published: Dec. 7, 2023
The
incidence
and
mortality
of
lung
cancer
are
on
the
rise
worldwide.
However,
benefit
clinical
treatment
in
is
limited.
Owning
to
important
sources
drug
development,
natural
products
have
received
constant
attention
around
world.
Main
ingredient
polysaccharides
been
found
various
activities
pharmacological
research.
In
recent
years,
more
scientists
looking
for
effects
mechanisms
different
product
cancer.
this
review,
we
focus
following
aspects:
First,
discovered
directly
suppress
growth
cells,
which
can
be
effective
limiting
tumor
progression.
Additionally,
considered
enhance
immune
function,
play
a
pivotal
role
fighting
Lastly,
improve
efficacy
drugs
by
regulating
gut
microbiota.
Overall,
research
promising
area
that
has
potential
lead
new
treatments.
With
better
understanding,
become
components
future
