Turkish Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
0(0), P. 0 - 0
Published: March 5, 2024
Objectives:
Variations
in
the
types
and
quantities
of
excipients
used
to
prepare
liposomes
can
affect
physicochemical
properties
formulation.This
study
aims
provide
information
about
design
fabrication
5-Fluorouracil
(5-FU)-loaded
liposome
formulations
using
different
lipid
cholesterol
derivatives.Materials
Methods:
Passive
loading
with
small
volume
incubation
method
was
for
preparation
liposomes.Particle
size,
polydispersity
index,
zeta
potential,
encapsulation
efficiency
(EE%)
were
determined.The
release
studies
conducted
a
Franz
diffusion
cell
at
37
°C.In
study,
high-pressure
liquid
chromatography
(HPLC)
device
measure
amount
5-FU.Results:
All
formulations'
mean
sizes
between
134
166
nm,
they
had
negative
charge
on
their
surface.Increasing
cholesteryl
hemisuccinate
content
resulted
reduction
size
liposomes.Additionally,
all
low
index
value,
which
less
than
0.3.All
have
an
EE%
more
30%.Also,
vitro
5-FU
from
followed
Korsemeyer-Peppas
model.
Conclusion:Modifying
formulations,
as
indicated
by
experimental
results,
change
characteristic
liposomes.The
use
soybean
phosphatidylcholine
cholesteyl
appears
promising
combination
hydrophilic
drug-loaded
formulations.
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Theranostics
is
a
way
of
treating
illness
that
blends
medicine
with
testing.
Specific
characteristics
should
be
present
in
the
best
theranostic
agents
for
cancer:
(1)
drugs
safe
and
non-toxic;
(2)
they
able
to
treat
cancer
selectively;
(3)
build
up
only
cancerous
tissue.
Liposomes
(LPs)
are
one
most
efficient
drug
delivery
methods
based
on
nanotechnology.
Stealth
LPs
commercial
have
recently
had
an
impact
treatment.
Using
valuable
information
from
each
imaging
technique,
along
multimodality
functionality
liposomal
therapeutic
agents,
makes
them
very
appealing
personalized
monitoring
how
well
working
against
vivo
predicting
therapies
will
work.
On
other
hand,
their
use
as
nanoparticle
systems
currently
research
development
phase.
Nanoscale
system
innovation
has
made
LP-nanoparticle
hybrid
structures
useful
combining
methods.
LP-hybrid
nanoparticles
better
at
killing
cells
than
LP
counterparts,
making
excellent
options
vitro
applications.
Hybrid
liposomes
(HLs)
could
used
future
carriers
find
targets.
This
would
combine
features
synthetic
biological
systems.
Overarchingly,
this
article
provided
comprehensive
overview
many
types
detection,
therapy,
analysis.
An
evaluation
pros
cons
HLs
detection
treatment
also
been
conducted.
The
study
included
recent
significant
We
conclude
by
outlining
potential
benefits
drawbacks
approach
concurrent
different
malignancies,
its
prospects.
Turkish Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
21(6), P. 551 - 556
Published: Jan. 10, 2025
Objectives:
Variations
in
the
types
and
quantities
of
excipients
used
to
prepare
liposomes
can
affect
physicochemical
properties
liposome
formulations.This
study
aimed
provide
information
about
design
fabrication
5-fluorouracil
(5-FU)-loaded
formulations
using
different
lipid
cholesterol
(CHOL)
derivatives.Materials
Methods:
Passive
loading
via
a
small-volume
incubation
method
was
liposomes.The
particle
size,
polydispersity
index,
zeta
potential,
encapsulation
efficiency
(EE%)
were
determined.The
release
studies
conducted
Franz
diffusion
cell
at
37
°C.In
this
study,
high-pressure
liquid
chromatography
device
measure
amount
5-FU.Results:
The
mean
sizes
all
between
134
166
nm,
they
had
negative
charge
on
their
surface.Increasing
cholesteryl
hemisuccinate
content
reduced
size
liposomes.Additionally,
exhibited
low
index
(0.3).The
EE%
exceeded
30%.The
vitro
5-FU
from
followed
Korsemeyer-Peppas
model.
Conclusion:Modifying
CHOL
formulations,
as
indicated
by
experimental
results,
change
characteristic
use
soybean
phosphatidylcholine
appears
be
promising
combination
for
preparation
hydrophilic
drug-loaded
formulations.
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(17), P. 4275 - 4308
Published: Jan. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 5955 - 5955
Published: Aug. 8, 2023
As
a
therapeutic
tool
inherited
for
thousands
of
years,
traditional
Chinese
medicine
(TCM)
exhibits
superiority
in
tumor
therapy.
The
antitumor
active
components
TCM
not
only
have
multi-target
treatment
modes
but
can
also
synergistically
interfere
with
growth
compared
to
chemotherapeutics.
However,
most
the
characteristics
poor
solubility,
high
toxicity,
and
side
effects,
which
are
often
limited
clinical
application.
In
recent
delivering
by
nanosystems
has
been
promising
field.
advantages
nano-delivery
systems
include
improved
water
targeting
efficiency,
enhanced
stability
vivo,
controlled
release
drugs,
achieve
higher
drug-delivery
efficiency
bioavailability.
According
method
drug
loading
on
nanocarriers,
be
categorized
into
two
types,
including
physically
encapsulated
nanoplatforms
chemically
coupled
platforms.
this
review,
approaches
considered,
namely
physical
encapsulation
chemical
coupling,
both
commonly
used
deliver
TCM,
we
summarized
limitations
different
types
systems.
Meanwhile,
applications
potential
toxicity
future
development
challenges
these
discussed,
aiming
lay
foundation
practical
application
settings.
International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1021 - 1046
Published: Jan. 1, 2025
Colorectal
cancer
(CRC)
is
the
second
leading
cause
of
cancer-related
deaths
worldwide.
Oxaliplatin
(OXA)
currently
primary
chemotherapeutic
agent
for
CRC,
but
its
efficacy
limited
by
tumor
microenvironment
(TME).
Here,
we
present
a
combined
approach
chemotherapy
and
TME
modulation
CRC
treatment.
A
multifunctional
nanosystem
(Rg3-Lip-OXA/CaO2)
was
established
using
Ginsenoside
Rg3
liposomes
targeting
glucose
transporter
1
overexpressed
on
surface
cells
to
co-deliver
OXA
calcium
peroxide
(CaO2).
The
CaO2
nanoparticles
were
synthesized
via
CaCl2-H2O2
reaction
under
alkaline
conditions
characterized
X-ray
diffraction
(XRD)
photoelectron
spectroscopy
(XPS).
Rg3-Lip-OXA/CaO2
prepared
through
thin-film
hydration
characterized;
additionally,
stability
release
behavior
studied.
O2,
H2O2,
Ca2+
generation
ability
in
solution
HCT116
measured.
vitro
cellular
uptake
observed
fluorescence
microscope
flow
cytometry.
In
cytotoxicity
evaluated
CCK-8
assay,
cytometry,
live/dead
cell
staining.
vivo
effect
as
well
antitumor
determined
tumor-bearing
mice.
Finally,
acute
toxicity
investigated
ICR
mice
explore
safety.
XRD
XPS
analyses
confirmed
successful
synthesis
nanoparticles.
exhibited
an
average
particle
size
approximately
92.98
nm
with
good
sustained
behavior.
studies
optimal
Rg3-Lip
demonstrated
that
effectively
produced
H2O2
Ca2+,
resulting
significant
cytotoxicity.
Additionally,
revealed
substantial
growth
suppression
reduced
tumor-associated
fibroblasts
(TAFs)
collagen.
Acute
indicated
markedly
drugs.
This
enhances
reduces
toxicity,
offering
promising
optimizing
treatment
potential
clinical
application.
