International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114654 - 114654
Published: April 27, 2025
Language: Английский
Biomolecules, Journal Year: 2024, Volume and Issue: 14(3), P. 334 - 334
Published: March 12, 2024
The human gastrointestinal system is a complex ecosystem crucial for well-being. During sepsis-induced gut injury, the integrity of intestinal barrier can be compromised. Lipopolysaccharide (LPS), an endotoxin from Gram-negative bacteria, disrupts barrier, contributing to inflammation and various dysfunctions. current study explores protective effects limonene, natural compound with diverse biological properties, against LPS-induced jejunal injury in mice. Oral administration limonene at dosages 100 200 mg/kg was used LPS mouse model. Murine Sepsis Score (MSS) utilized evaluate severity sepsis, while serum levels urea creatinine served as indicators renal function. Our results indicated that injection induced function deterioration, evidenced by elevated compared control However, pretreatment doses mitigated this decline function, reduced creatinine. Limonene demonstrated anti-inflammatory reducing pro-inflammatory cytokines (TNF-α, IL-1β, COX-2), suppressing TLR4/NF-κB/AP-1 but not IRF3 signaling pathways, modulating oxidative stress through Nrf2 activation. suggest holds promise potential therapeutic agent mitigating preserving health.
Language: Английский
Citations
14
Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.
Language: Английский
Citations
1
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(7), P. 3572 - 3583
Published: Feb. 9, 2024
In this study, we aimed to explore the protective effects of Bifidobacterium in colitis mice and potential mechanisms. Results showed that breve (B. breve) effectively colonized intestinal tract alleviated symptoms by reducing disease activity index. Moreover, B. mitigated epithelial cell damage, inhibited pro-inflammatory factors, upregulated tight junction (TJ)-proteins. Gut microbiota metabolome analysis found boosted bile acid-regulating genera (such as Clostridium sensu stricto 1), which promoted acid deconjugation intestine. Notably, cholic (CA) was closely associated with expression levels inflammatory factors TJ-proteins (p < 0.05). Our vitro experiments further confirmed CA (20.24 ± 4.53 pg/mL) contributed inhibition lipopolysaccharide-induced tumor necrosis factor-α (49.32 5.27 enhanced (Occludin Claudin-1) MUC2. This study suggested could be a probiotic candidate for use infant foods.
Language: Английский
Citations
7
Compounds, Journal Year: 2024, Volume and Issue: 4(2), P. 376 - 400
Published: June 10, 2024
Inflammation and thrombosis are implicated in several chronic disorders. Recent studies have outlined the way which compounds can offer protection against inflammation. Within this comprehensive review so-far reported anti-inflammatory health-promoting effects of metal-based complexes, both vitro vivo, thoroughly presented. These usually interfere with various biochemical processes associated inflammatory response thrombus formation become capable inhibiting these pathways proposed health benefits. Emphasis is given to multifaceted actions complexes that exhibited potent antithrombotic activities mediator, platelet-activating factor (PAF), its thrombo-inflammatory signaling, as well on their anti-platelet antitumor promoting properties. Furthermore, enhancement potency well-established bioactive by incorporation ligands discussed. Metal-based bearing natural bioactives also outlined. Characteristic examples free porphyrins explored. recognized assets, addition other pleiotropic advantages including antibacterial or anticancer actions. Additionally, applications metal models thrombotic complications demonstrated. The combined results study show further research required towards preparation improved pharmacological profiles. Finally, restrictions application covered, along prospects for future need additional order improve efficacy safety.
Language: Английский
Citations
6
Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(3), P. 100604 - 100604
Published: June 28, 2024
Cyanobacteria are highly regarded for their nutritional value and the scientific community has shown great interest in studying biological activity bioactive compounds, especially pigments. They have a wide range of properties, making them potentially useful various health applications, including dermatology. Given growing demand natural products actives cosmetics medical sectors, these microorganisms emerged as valuable source. Therefore, this study investigated bioactivity phycoerythrin (PE) phycocyanin (PC) extracted from Nostoc sp. Spirulina on CCD-966SK cell lines, specifically focusing apoptosis, necrosis, anti-inflammatory effects, enzymatic reactions. The involved conducting bioassays human skin fibroblast line (CCD-966SK) after performing cyanobacterial culture, pigment extraction, culture. included MTT test, TNF-α IL-6 release assays, measurement collagen I III, assessment apoptosis analysis enzyme superoxide dismutase (SOD) glutathione peroxidase (GPx). cytotoxicity test results indicated that higher concentrations PE PC were associated with lower survival rates. flow cytometry confirmed significant increase necrotic cells decrease living at high both largest percentages identified 125 62.5 ppm, whereas lowest quantities reported 1000 ppm had highest II 3.91 15.63 respectively. levels ppm. released TNF-a cytokines, indicating inflammation resistance. Superoxide (GPx) malondialdehyde (MDA) showed pigments most active In conclusion, exhibited positive effects enhancing necrotic, anti-inflammatory, against line.
Language: Английский
Citations
6
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 29, 2024
The pulp is a unique tissue within each tooth that susceptible to painful inflammation, known as pulpitis, triggered by microbial invasion from carious lesions or trauma affect many individuals. host response involves complex immunological processes for pathogen defense and dentin apposition at the site of infection. interplay signaling between immune non-immune cells via cytokines, chemokines, neuropeptides, proteases, reactive nitrogen oxygen species leads reactions structural changes in escalate beyond certain threshold irreversible damage. If left untreated, which initially localized, can progress pulpal necrosis, requiring root canal treatment adversely affecting prognosis tooth. To preserve vitality dental health, deeper understanding molecular cellular mechanisms pulpitis imperative. In particular, elucidating links pathways, clinical symptoms, spatiotemporal spread essential develop novel therapeutic strategies push boundaries vital therapy.
Language: Английский
Citations
6
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: April 2, 2024
Background: Depression is a severe mental disorder that poses significant threat to both the physical and wellbeing of individuals. Currently, there are various methods for treating depression, including traditional Chinese herbal formulations like Chaihu-Shugan-San (CSS), which have shown effective antidepressant effects in clinical animal research. Objective: This review aims provide comprehensive synthesis evidence related CSS, considering preclinical studies, uncover its potential multi-level, multi-pathway, multi-target mechanisms depression identify active ingredients. Methods: A thorough search was conducted electronic databases, PubMed, MEDLINE, Web Science, Google Scholar, CNKI, Wanfang, using keywords such as “Chaihu Shugan” “depression” retrieve relevant literature on CSS The process adhered PRISMA guidelines. Results: consolidates underlying It emphasizes involvement regulation monoaminergic neurotransmitter systems, synaptic plasticity, hypothalamic-pituitary-adrenal axis, among other aspects. Conclusion: exerts pivotal role through pathways, system, inflammation, brain-derived neurotrophic factor levels, brain-gut axis. facilitates understanding current state research, fostering an in-depth exploration etiological discovery novel drugs.
Language: Английский
Citations
4
RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(8), P. 2692 - 2708
Published: Jan. 1, 2024
Trimethoxy derivatives 5f (IC 50 = 1.50 μM) and 6f 1.15 demonstrated higher COX-2 inhibitory activity than celecoxib. Also, they showed the highest inhibition of NO, TNF-α, IL-6, PGE-2 production in LPS-induced RAW264.7 macrophages.
Language: Английский
Citations
4
Periodontology 2000, Journal Year: 2024, Volume and Issue: 96(1), P. 229 - 249
Published: Aug. 23, 2024
Abstract Chronic inflammation poses challenges to effective cancer treatment. Although anti‐inflammatory therapies have shown short‐term benefits, their long‐term implications may be unfavorable because they fail initiate the necessary inflammatory responses. Recent research underscores promise of specialized pro‐resolving mediators, which play a role in modulating microenvironment by promoting resolution initiated processes and restoring tissue hemostasis. This review addresses current insights into how contributes pathogenesis explores recent strategies resolve associated with cancer.
Language: Английский
Citations
4
Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 119, P. 118061 - 118061
Published: Jan. 5, 2025
Language: Английский
Citations
0