Diagnostics,
Journal Year:
2025,
Volume and Issue:
15(2), P. 123 - 123
Published: Jan. 7, 2025
With
the
advent
of
a
variety
vaccines
against
viral
infections,
there
are
multiple
viruses
that
can
be
prevented
via
vaccination.
However,
breakthrough
infections
or
uncovered
strains
still
cause
vaccine-preventable
(VPVIs).
Therefore,
timely
diagnosis,
treatment,
and
surveillance
these
is
critical
to
patient
care
public
health.
Point-of-care
(POC)
diagnostics
tools
have
brought
significant
improvements
in
detection
management
VPVIs.
These
cutting-edge
technologies
enable
prompt
accurate
results,
enhancing
by
facilitating
treatment
decisions.
This
review
delves
into
advancements
POC
testing,
including
antigen/antibody
molecular
assays,
while
focusing
on
their
impact
VPVIs
such
as
mpox,
hepatitis,
influenza,
flaviviruses
(dengue,
Zika,
yellow
fever
virus),
COVID-19.
The
role
tests
monitoring
infection
crucial
for
tracking
disease
progression
managing
outbreaks.
Furthermore,
application
has
shown
vital
health
strategies.
In
this
review,
we
also
highlight
emerging
CRISPR-based
smartphone-integrated
devices,
which
proven
particularly
beneficial
resource-limited
settings.
We
underscore
importance
continued
research
optimize
diagnostic
wider
global
use
dengue,
COVID-19,
addressing
current
challenges
related
sensitivity,
specificity,
availability,
efficiency,
more.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(5), P. 7899 - 7906
Published: May 13, 2021
Point-of-care
(POC)
detection
technologies
that
enable
decentralized,
rapid,
sensitive,
low-cost
diagnostics
of
COVID-19
infection
are
urgently
needed
around
the
world.
With
many
approved
for
commercialization
in
past
10
months,
field
POC
is
rapidly
evolving.
In
this
Perspective,
we
analyze
current
state
diagnosis
and
monitoring
discuss
future
challenges
diagnostics.
As
pandemic
becomes
endemic,
advances
gained
during
year
will
likely
also
be
utilized
prediction
emerging
outbreaks
pandemics.
International Journal of Molecular Medicine,
Journal Year:
2021,
Volume and Issue:
47(6)
Published: April 12, 2021
The
Coronavirus
Disease
2019
(COVID‑19)
pandemic
has
forced
the
scientific
community
to
rapidly
develop
highly
reliable
diagnostic
methods
in
order
effectively
and
accurately
diagnose
this
pathology,
thus
limiting
spread
of
infection.
Although
structural
molecular
characteristics
severe
acute
respiratory
syndrome
coronavirus
2
(SARS‑CoV‑2)
were
initially
unknown,
various
strategies
useful
for
making
a
correct
diagnosis
COVID‑19
have
been
developed
by
private
research
laboratories
biomedical
companies.
At
present,
rapid
antigen
or
antibody
tests,
immunoenzymatic
serological
tests
based
on
RT‑PCR
are
most
widely
used
validated
techniques
worldwide.
Apart
from
these
conventional
methods,
other
techniques,
including
isothermal
nucleic
acid
amplification
clusters
regularly
interspaced
short
palindromic
repeats/Cas
(CRISPR/Cas)‑based
approaches
digital
PCR
currently
contexts
awaiting
approval
use
competent
authorities.
In
provide
guidance
present
review
describes
available
which
may
be
infection
both
clinical
settings.
particular,
technical
instrumental
described
herein.
addition,
updated
detailed
information
about
type
sample,
modality
timing
specific
also
discussed.
ACS Sensors,
Journal Year:
2021,
Volume and Issue:
6(4), P. 1430 - 1445
Published: Jan. 27, 2021
The
emergence
of
the
new
coronavirus
2019
(COVID-19)
was
first
seen
in
December
2019,
which
has
spread
rapidly
and
become
a
global
pandemic.
number
cases
COVID-19
its
associated
mortality
have
raised
serious
concerns
worldwide.
Early
diagnosis
viral
infection
undoubtedly
allows
rapid
intervention,
disease
management,
substantial
control
disease.
Currently,
standard
approach
for
globally
is
RT-qPCR
test;
however,
limited
access
to
kits
reagents,
need
specialized
lab
equipment,
highly
skilled
personnel
led
detection
slowdown.
Recently,
development
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)-based
diagnostic
systems
reshaped
molecular
diagnosis.
benefits
CRISPR
system
such
as
speed,
precision,
specificity,
strength,
efficiency,
versatility
inspired
researchers
develop
CRISPR-based
therapeutic
methods.
With
outbreak,
different
groups
begun
design
programs
based
on
efficient
system.
advantages
high
speed
(i.e.,
30
min
from
raw
sample
reach
result),
sensitivity
portability,
no
laboratory
equipment.
Here,
we
review
contemporary
studies
