Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1654 - 1654
Published: Nov. 29, 2023
Neural
transplantation
represents
a
promising
approach
to
repairing
damaged
brain
circuitry.
Cellular
grafts
have
been
shown
promote
functional
recovery
through
“bystander
effects”
and
other
indirect
mechanisms.
However,
extensive
lesions
may
require
direct
neuronal
replacement
achieve
meaningful
restoration
of
function.
While
fetal
cortical
integrate
with
the
host
appear
develop
appropriate
attributes,
significant
ethical
concerns
limited
availability
this
tissue
severely
hamper
clinical
translation.
Induced
pluripotent
stem
cell-derived
cells
tissues
represent
more
readily
scalable
alternative.
Significant
progress
has
recently
made
in
developing
protocols
for
generating
wide
range
neural
cell
types
vitro.
Here,
we
discuss
recent
approaches
two
conditions
distinct
design
needs:
Parkinson’s
disease
injury.
We
current
status
future
application
injections
dopaminergic
treatment
as
well
use
structured
such
organoids
repair.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(11)
Published: Jan. 11, 2022
Human
induced
pluripotent
stem
cell
derived
brain
organoids
have
shown
great
potential
for
studies
of
human
development
and
neurological
disorders.
However,
quantifying
the
evolution
electrical
properties
during
is
currently
limited
by
measurement
techniques,
which
cannot
provide
long-term
stable
3D
bioelectrical
interfaces
with
developing
organoids.
Here,
a
cyborg
organoid
platform
reported,
in
"tissue-like"
stretchable
mesh
nanoelectronics
are
designed
to
match
mechanical
be
folded
organogenetic
process
progenitor
or
cells,
distributing
electrode
arrays
across
The
tissue-wide
integrated
show
no
interruption
development,
adapt
volume
morphological
changes
organogenesis,
contacts
neurons
within
development.
seamless
noninvasive
coupling
electrodes
enables
stable,
continuous
recording
captures
emergence
single-cell
action
potentials
from
early-stage
Advanced Materials Technologies,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
Human
brain
organoids,
which
originate
from
pluripotent
stem
cells,
serve
as
valuable
tools
for
a
wide
range
of
research
endeavors,
replicating
function.
Their
capacity
to
replicate
cellular
interactions,
morphology,
and
division
provides
invaluable
insights
into
development,
disease
modeling,
drug
screening.
However,
conventional
morphological
analysis
methods
are
often
invasive
lack
real‐time
monitoring
capabilities,
posing
limitations
achieving
comprehensive
understanding.
Therefore,
advancing
the
comprehension
organoid
electrophysiology
necessitates
development
minimally
measurement
technologies
with
long‐term,
high‐resolution
capabilities.
This
review
highlights
significance
human
organoids
emphasizes
need
electrophysiological
characterization.
It
delves
assessment
methods,
particularly
focusing
on
3D
microelectrode
arrays,
electrode
insertion
mechanisms,
importance
flexible
arrays
facilitate
recordings.
Additionally,
various
sensors
tailored
monitor
properties
introduced,
enriching
understanding
their
chemical,
thermal,
mechanical
dynamics.
ALTEX,
Journal Year:
2023,
Volume and Issue:
unknown, P. 191 - 203
Published: Jan. 1, 2023
Understanding
brain
function
remains
challenging
as
work
with
human
and
animal
models
is
complicated
by
compensatory
mechanisms,
while
in
vitro
have
been
too
simple
until
now.
With
the
advent
of
stem
cells
bioengineering
microphysiological
systems
(MPS),
understanding
how
both
cognition
long-term
memory
arise
now
coming
into
reach.
We
suggest
combining
cutting-edge
AI
MPS
research
to
spearhead
organoid
intelligence
(OI)
synthetic
biological
intelligence.
The
vision
realize
cognitive
functions
scale
them
achieve
relevant
short-
capabilities
basic
information
processing
ultimate
functional
experimental
for
neurodevelopment
neurological
cell-based
assays
drug
chemical
testing.
By
advancing
frontiers
computing,
we
aim
(a)
create
intelligence-in-a-dish
study
basis
functions,
(b)
provide
advance
search
toxicants
contributing
diseases
identify
remedies
maladies,
(c)
computational
capacities
complement
traditional
computing.
Increased
functionality,
some
respects
still
superior
today's
supercomputers,
may
allow
imitate
this
neuromorphic
computer
architectures
or
might
even
open
up
computing
silicon
computers.
At
same
time,
raises
ethical
questions
such
where
sentience
consciousness
start
what
relationship
between
a
cell
donor
respective
OI
system
is.
Such
discussions
will
be
critical
socially
acceptable
cognition.
Cells,
Journal Year:
2022,
Volume and Issue:
11(18), P. 2803 - 2803
Published: Sept. 8, 2022
The
cerebral
cortex
forms
early
in
development
according
to
a
series
of
heritable
neurodevelopmental
instructions.
Despite
deep
evolutionary
conservation
the
and
its
foundational
six-layered
architecture,
significant
variations
cortical
size
folding
can
be
found
across
mammals,
including
disproportionate
expansion
prefrontal
humans.
Yet
our
mechanistic
understanding
processes
is
derived
overwhelmingly
from
rodent
models,
which
fail
capture
many
human-enriched
features
development.
With
advent
pluripotent
stem
cells
technologies
for
differentiating
three-dimensional
cultures
neural
tissue
vitro,
organoids
have
emerged
as
an
experimental
platform
that
recapitulates
several
hallmarks
human
brain
In
this
review,
we
discuss
merits
limitations
models
developing
brain.
We
highlight
innovations
technology
seek
increase
fidelity
vivo
recent
efforts
use
study
regeneration
evolution
well
develop
neurological
neuropsychiatric
disease
models.
Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: April 15, 2024
Flexible
high-density
microelectrode
arrays
(HDMEAs)
are
emerging
as
a
key
component
in
closed-loop
brain–machine
interfaces
(BMIs),
providing
high-resolution
functionality
for
recording,
stimulation,
or
both.
The
flexibility
of
these
provides
advantages
over
rigid
ones,
such
reduced
mismatch
between
interface
and
tissue,
resilience
to
micromotion,
sustained
long-term
performance.
This
review
summarizes
the
recent
developments
applications
flexible
HDMEAs
BMI
systems.
It
delves
into
various
challenges
encountered
development
ideal
systems
highlights
latest
methodologies
breakthroughs
address
challenges.
These
insights
could
be
instrumental
guiding
creation
future
generations
HDMEAs,
specifically
tailored
use
BMIs.
thoroughly
explores
both
current
state
prospects
advanced
arrays,
emphasizing
their
potential
enhancing
technology.
Lab on a Chip,
Journal Year:
2023,
Volume and Issue:
23(16), P. 3603 - 3614
Published: Jan. 1, 2023
An
array
of
protruding
cantilever
microelectrodes
has
been
developed
to
measure
the
inner
electrical
activity
a
cerebral
organoid
grown
from
human
embryonic
stem
cells.
