Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(8), P. 3432 - 3456

Published: May 13, 2024

The advent of cancer immunotherapy has imparted a transformative impact on treatment paradigms by harnessing the power immune system. However, challenge practical and precise targeting malignant cells persists. To address this, engineered nanoparticles (NPs) have emerged as promising solution for enhancing targeted drug delivery in immunotherapeutic interventions, owing to their small size, low immunogenicity, ease surface modification. This comprehensive review delves into contemporary research at nexus NP engineering immunotherapy, encompassing an extensive spectrum morphologies strategies tailored toward optimizing tumor augmenting therapeutic effectiveness. Moreover, it underscores mechanisms that NPs leverage bypass numerous obstacles encountered regimens probes combined potential when co-administered with both established novel modalities. Finally, evaluates existing limitations platforms which could shape path future advancements this field.

Language: Английский

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Enhancing drug penetration in solid tumors via nanomedicine: Evaluation models, strategies and perspectives

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 445 - 472

Published: Oct. 26, 2023

Effective tumor treatment depends on optimizing drug penetration and accumulation in tissue while minimizing systemic toxicity. Nanomedicine has emerged as a key solution that addresses the rapid clearance of free drugs, but achieving deep into solid tumors remains elusive. This review discusses various strategies to enhance penetration, including manipulation microenvironment, exploitation both external internal stimuli, pioneering nanocarrier surface engineering, development innovative tactics for active penetration. One outstanding strategy is organelle-affinitive transfer, which exploits unique properties specific cell organelles heralds potentially transformative approach transcellular transfer Rigorous models are essential evaluate efficacy these strategies. The patient-derived xenograft (PDX) model gaining traction bridge between laboratory discovery clinical application. However, journey from bench bedside nanomedicines fraught with challenges. Future efforts should prioritize deepening our understanding nanoparticle-tumor interactions, re-evaluating EPR effect, exploring novel nanoparticle transport mechanisms.

Language: Английский

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Hypoxia Reversion by Low-Immunogenic Ultra-Acid-Sensitive Comicelles of Protein–Polymer Conjugates Sensitizes Tumors to Photodynamic Therapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(11), P. 7543 - 7554

Published: March 12, 2024

Hypoxia is characteristic of the tumor microenvironment, which correlated with resistance to photodynamic therapy (PDT), radiotherapy, chemotherapy, and immunotherapy. Catalase potentially useful catalyze conversion endogenous H2O2 O2 for hypoxia reversion. However, efficient delivery catalase into regions tumors a huge challenge. Here, we report self-assembly ultra-acid-sensitive polymer conjugates albumin nanomicelles that are responsive acidic microenvironment. The immunogenicity mitigated by presence albumin, reduces cross-linking B cell receptors, resulting in improved pharmacokinetics. ultra acid sensitivity makes it possible efficiently escape lysosomal degradation after endocytosis permeate interior reverse vitro vivo. In mice bearing triple-negative breast cancer, loaded photosensitizer effectively accumulate penetrate whole generate sufficient amount hypoxia, leading enhanced efficacy PDT without detectable side effects. These findings provide general strategy design low-immunogenic comicelles protein–polymer sensitizes PDT.

Language: Английский

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Interrogation of the Tumor Microenvironment by Nanoparticles

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217454 - 217454

Published: Jan. 1, 2025

Language: Английский

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β-Cyclodextrin-based polyelectrolyte complexes for drug delivery

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216581 - 216581

Published: March 11, 2025

Language: Английский

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Personalized Cancer Nanomedicine: Overcoming Biological Barriers for Intracellular Delivery of Biopharmaceuticals

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(14)

Published: Dec. 17, 2023

The success of personalized medicine in oncology relies on using highly effective and precise therapeutic modalities such as small interfering RNA (siRNA) monoclonal antibodies (mAbs). Unfortunately, the clinical exploitation these biological drugs has encountered obstacles overcoming intricate barriers. Drug delivery technologies represent a plausible strategy to overcome barriers, ultimately facilitating access intracellular domains. Here, an overview current landscape how nanotechnology dealt with protein corona phenomena first determinant barrier is presented. This continues analysis strategies tumor, along conceivable methods for enhanced tumor penetration. As final step, cellular barriers that nanocarriers must confront order their cargo reach target are deeply analyzed. review concludes critical future perspectives translational advances oncological nanomedicine.

Language: Английский

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Biopolymer-Based Nanomedicine for Cancer Therapy: Opportunities and Challenges

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7415 - 7471

Published: July 1, 2024

Abstract: Cancer, as the foremost challenge among human diseases, has plagued medical professionals for many years. While there have been numerous treatment approaches in clinical practice, they often cause additional harm to patients. The emergence of nanotechnology brought new directions cancer treatment, which can deliver anticancer drugs specifically tumor areas. This article first introduces application scenarios nanotherapies and strategies nanomedicine. Then, noteworthy characteristics exhibited by biopolymer materials were described, make biopolymers stand out polymeric nanomedicine delivery. Next, we focus on summarizing state-of-art studies five categories proteins (Albumin, Gelatin, Silk fibroin, Zein, Ferritin), nine varieties polysaccharides (Chitosan, Starch, Hyaluronic acid, Dextran, cellulose, Fucoidan, Carrageenan, Lignin, Pectin) liposomes field drug Finally, also provide a summary advantages limitations these biopolymers, discuss prevailing impediments their application, detail prospective research directions. review not only helps readers understand current development status nano delivery systems based but is helpful properties various find suitable solutions this through comparative reading. Keywords: delivery, nanoformulations, polymer, proteins,

Language: Английский

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Advances in and prospects of immunotherapy for prostate cancer

Cancer Letters, Journal Year: 2024, Volume and Issue: 601, P. 217155 - 217155

Published: Aug. 8, 2024

Immunotherapy has shown promising therapeutic effects in hematological malignancies and certain solid tumors emerged as a critical highly potential treatment modality for cancer. However, prostate cancer falls under the category of immune-resistant cold tumors, which immunotherapy exhibits limited efficacy patients with tumors. Thus, it is important to gain deeper understanding tumor microenvironment facilitate immune system activation overcome suppression advance In this review, we discuss immunosuppressive cancer, characterized by presence few tumor-infiltrating lymphocytes, abundant cells, low immunogenicity, noninflammatory phenotype, significantly influences mainly achieved activating host overcoming immunosuppression. regard, summarize advances checkpoint blockade, immunogenic cell death, reversal microenvironment, vaccines, adjuvants, chimeric antigen receptor T-cell therapy, penetration barriers aim providing novel research insights approaches enhance effectiveness

Language: Английский

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Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 16, 2023

Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in cancer therapy. This article provides comprehensive review of recent advancements the field nanomedicines targeting TAMs. According to crucial role TAMs tumor progression, strategies inhibit macrophage recruitment, suppress TAM survival, and transform phenotypes are discussed potential therapeutic avenues. To enhance capacity nanomedicines, various approaches such use ligands, immunoglobulins, short peptides explored. The utilization live programmed macrophages, cell membrane-coated nanoparticles macrophage-derived extracellular vesicles drug delivery platforms is also highlighted, offering improved biocompatibility prolonged circulation time. However, challenges remain achieving precise controlled release. heterogeneity variability surface markers pose hurdles specific recognition. Furthermore, safety clinical applicability these requires further investigation. In conclusion, hold great promise therapy, enhanced specificity reduced side effects. Addressing existing limitations expanding our understanding biology will pave way for successful translation nano-therapies into practice.

Language: Английский

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The New Era of Pancreatic Cancer Treatment: Application of Nanotechnology Breaking Through Bottlenecks

Cancer Letters, Journal Year: 2024, Volume and Issue: 594, P. 216979 - 216979

Published: May 23, 2024

Language: Английский

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