A novel electrochemical immunosensor for ultrasensitive detection of CA125 in ovarian cancer

Biosensors and Bioelectronics, Journal Year: 2020, Volume and Issue: 153, P. 112029 - 112029

Published: Jan. 16, 2020

Language: Английский

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Preparation of a chitosan-chlorogenic acid conjugate and its application as edible coating in postharvest preservation of peach fruit

Postharvest Biology and Technology, Journal Year: 2019, Volume and Issue: 154, P. 129 - 136

Published: May 10, 2019

Language: Английский

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Extraction, identification and quantification of polyphenols from spent coffee grounds by chromatographic methods and chemometric analyses

Waste Management, Journal Year: 2019, Volume and Issue: 96, P. 15 - 24

Published: July 11, 2019

Language: Английский

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Synthesis of superabsorbent polymers based on chitosan derivative graft acrylic acid-co-acrylamide and its property testing

International Journal of Biological Macromolecules, Journal Year: 2019, Volume and Issue: 132, P. 575 - 584

Published: March 26, 2019

Language: Английский

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Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(2), P. 499 - 499

Published: Jan. 13, 2020

As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple with active substances obtain conjugates diverse structures unique functions. particular, antimicrobial activity shown great application prospects fields medicine, food, agriculture years. Hence, we will place substantial emphasis on approaches for preparing their applications, which are not well summarized. Meanwhile, challenges, limitations, described discussed.

Language: Английский

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Polyphenol and Cu2+ surface-modified chitin sponge synergizes with antibacterial, antioxidant and pro-vascularization activities for effective scarless regeneration of burned skin

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 419, P. 129488 - 129488

Published: March 27, 2021

Language: Английский

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Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 11

Published: Jan. 4, 2022

Colitis, a chronic inflammatory bowel disease, is characterized by bloody diarrhea and inflammation in the colon. Lonicera hypoglauca (“Shanyinhua” Chinese) Scutellaria baicalensis (“Huangqin” are two traditional Chinese medicinal plants rich polyphenols, such as chlorogenic acid (CGA) baicalin (BA), with effects of anti-inflammation antioxidation. However, it remains unknown whether extracts from L. S. (LSEs) could mitigate colonic inflammation. In present study, ICR mice (22.23 ± 1.65 g) were allocated to three groups treated chow diet without (CON) or dextran sulfate sodium (DSS) (CON+DSS) water LSE supplementation DSS (LSE+DSS), then oxidative parameters microbiota detected. The results showed that (500 mg/kg) treatment mitigated DSS-induced colitis symptoms restored shortened colon length, increased disease activity index (DAI), damaged intestinal barrier. serum, significantly decreased levels pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, lipopolysaccharide (LPS) IL-10 level. Meanwhile, superoxide dismutase (SOD) catalase (CAT) increased, malondialdehyde (MDA) reactive oxygen species (ROS) decreased. tissue, qPCR dramatically downregulated transcriptional expression IL-1β , IL-6 TNF-α MDA upregulated SOD1 CAT . Additionally, gut barriers occludin zonula occludens-1 (ZO-1) CON+DSS group enhanced supplementation. Furthermore, regulated microbial communities higher relative abundance Dubosiella Ruminococcus torques lower Bacteroides Turicibacter Moreover, contents short-chain fatty acids (SCFAs) products also increased. Correlation analysis mRNA was negatively correlated (r = -0.900, P < 0.05); -0.779, 0.05) -0.703, had negative correlation conclusion, effectively ameliorate modulating stress mouse model.

Language: Английский

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Platelet Rich Plasma Loaded Multifunctional Hydrogel Accelerates Diabetic Wound Healing via Regulating the Continuously Abnormal Microenvironments

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)

Published: July 12, 2023

Continuous oxidative stress and cellular dysfunction caused by hyperglycemia are distinguishing features of diabetic wounds. It has been a great challenge to develop smart dressing that can accelerate wound healing through regulating abnormal microenvironments. In this study, platelet rich plasma (PRP) loaded multifunctional hydrogel with reactive oxygen species (ROS) glucose dual-responsive property is reported. be conveniently prepared PRP, dopamine (DA) grafted alginate (Alg-DA), 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (ABO) conjugated hyaluronic acid (HA-ABO) ionic crosslinks, hydrogen-bond interactions, boronate ester bonds. The possesses injectability, moldability, tissue adhesion, self-healing, low hemolysis, hemostasis performances. Its excellent antioxidant create microenvironment for other biological events. Under an and/or state, the degrade at accelerated rate release variety cytokines derived from activated blood platelets. result series positive changes favorable healing, including fast anti-inflammation, macrophage polarization toward M2 phenotype, promoted migration proliferation fibroblasts, as well expedited angiogenesis. This work provides efficient strategy chronic management offers alternative developing new-type PRP-based bioactive dressing.

Language: Английский

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Grafted ferulic acid dose-dependently enhanced the apparent viscosity and antioxidant activities of arabinoxylan

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 128, P. 107557 - 107557

Published: Jan. 31, 2022

Language: Английский

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Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols

Food Hydrocolloids, Journal Year: 2023, Volume and Issue: 146, P. 109221 - 109221

Published: Aug. 28, 2023

In recent years, the consumption of functional foods containing health-beneficial ingredients has become increasingly popular. Polyphenols are among most important and bioactive molecules found in a variety fresh produce food products. However, limited solubility polyphenols water can significantly affect their bioavailability, thereby reducing potential health benefits. To overcome this limitation, various approaches have been explored, including molecular enhancers, nanoparticles, encapsulation systems, conjugation methods. review, we focus on advances methods for enhancing bioavailability polyphenols. We provide concise overview types determination and, subsequently, discuss concept methods, different synthesizing confirmation procedures, effects polysaccharides Overall, review provides comprehensive update that be used to improve highlights these enhance benefits polyphenol-rich foods.

Language: Английский

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