Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2023, Volume and Issue: 676, P. 132061 - 132061
Published: July 16, 2023
Language: Английский
Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417
Published: Jan. 1, 2023
Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.
Language: Английский
Citations
147
Polymers, Journal Year: 2023, Volume and Issue: 15(10), P. 2317 - 2317
Published: May 16, 2023
Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to deliver anticancer drugs due its biocompatibility, biodegradability, non-toxicity, non-immunogenicity and numerous modification sites, such as carboxyl hydroxyl groups. Moreover, HA serves natural ligand for tumor-targeted drug delivery systems, it contains endocytic receptor, CD44, which overexpressed in many cancer cells. Therefore, HA-based nanocarriers have been developed improve efficiency distinguish between healthy cancerous tissues, resulting reduced residual toxicity off-target accumulation. This article comprehensively reviews fabrication based on context prodrugs, organic carrier materials (micelles, liposomes, nanoparticles, microbubbles hydrogels) inorganic composite (gold quantum dots, carbon nanotubes silicon dioxide). Additionally, progress achieved design optimization these their effects therapy are discussed. Finally, review provides summary perspectives, lessons learned so far outlook towards further developments this field.
Language: Английский
Citations
59
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 19 - 43
Published: Aug. 24, 2023
Language: Английский
Citations
55
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121897 - 121897
Published: Feb. 6, 2024
Language: Английский
Citations
19
Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 266, P. 111018 - 111018
Published: Sept. 21, 2023
Language: Английский
Citations
29
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 8143 - 8168
Published: Dec. 1, 2023
Abstract: Tremendous research efforts have been devoted to nanoparticles for applications in optoelectronics and biomedicine. Over the past decade, quantum dots (QDs) become one of fastest growing areas nanotechnology because outstanding photophysical properties, including narrow symmetrical emission spectrum, broad fluorescence excitation tenability wavelength with particle size composition, anti-photobleaching ability stable fluorescence. These characteristics are suitable optical imaging, drug delivery other biomedical applications. Research on QDs toxicology has demonstrated affect or damage biological system some extent, this situation is generally caused by metal ions special properties QDs, which hinders further application field. The toxicological mechanism mainly stems from release heavy generation reactive oxygen species (ROS). At same time, contact reaction also cause disorders organelles changes gene expression profiles. In review, we try present an overview toxicity related mechanisms different target organs. It believed that evaluation synthesis environmentally friendly primary issues be addressed future widespread However, considering many types potential modifications, review still not clearly elucidated, needed meaningful topic. Keywords: dots, nanotoxicology, nanoparticle, toxicity, cytotoxic
Language: Английский
Citations
27
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132671 - 132671
Published: May 31, 2024
Language: Английский
Citations
11
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 7289 - 7299
Published: March 28, 2024
The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer delivery release in tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed doxorubicin (DOX). profile suggested sustained micelles an accelerated at lower pH higher ROS levels. cellular uptake assay indicated that were internalized by HepG2 cells enhanced folate modification through receptor-mediated endocytosis pathway. Furthermore, nanocarriers demonstrated inhibition migration scratch test showed improved suppression proliferation IC50 than nonfolate viability test, indicating desirable vitro efficiency nanosystem.
Language: Английский
Citations
9
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135893 - 135893
Published: Sept. 1, 2024
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141236 - 141236
Published: Feb. 1, 2025
Language: Английский
Citations
0