Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 194, P. 104262 - 104262
Published: Jan. 8, 2024
Language: Английский
Cancer Cell, Journal Year: 2023, Volume and Issue: 41(11), P. 1945 - 1962.e11
Published: Oct. 19, 2023
Tumor microbiota can produce active metabolites that affect cancer and immune cell signaling, metabolism, proliferation. Here, we explore tumor gut microbiome features chemoradiation response in patients with cervical using a combined approach of deep sequencing, targeted bacterial culture, vitro assays. We identify an obligate L-lactate-producing lactic acid bacterium found tumors, Lactobacillus iners, is associated decreased survival patients, induces chemotherapy radiation resistance cells, leads to metabolic rewiring, or alterations multiple pathways, tumors. Genomically similar bacteria commensal other body sites are also significantly colorectal, lung, head neck, skin cancers. Our findings demonstrate the microenvironment alter metabolism lactate signaling causing therapeutic resistance. Lactic could be promising targets across types.
Language: Английский
Citations
91
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: June 4, 2024
Abstract Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook and prognosis for this resistant type tumor have remained grim long time. Currently, it extremely challenging to prevent or detect early enough effective treatment because patients rarely exhibit symptoms there are no reliable indicators detection. Most advanced spreading that difficult treat, treatments like chemotherapy radiotherapy can only slightly prolong their life by few months. Immunotherapy has revolutionized pancreatic cancer, yet its effectiveness limited tumor's immunosuppressive hard-to-reach microenvironment. First, article explains microenvironment highlights wide range immunotherapy options, including therapies involving oncolytic viruses, modified T cells (T-cell receptor [TCR]-engineered chimeric antigen [CAR] T-cell therapy), CAR natural killer cell therapy, cytokine-induced cells, immune checkpoint inhibitors, immunomodulators, vaccines, strategies targeting myeloid in context contemporary knowledge future trends. Lastly, discusses main challenges ahead immunotherapy.
Language: Английский
Citations
36
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Sept. 27, 2024
Abstract Cells, as the fundamental units of life, contain multidimensional spatiotemporal information. Single-cell RNA sequencing (scRNA-seq) is revolutionizing biomedical science by analyzing cellular state and intercellular heterogeneity. Undoubtedly, single-cell transcriptomics has emerged one most vibrant research fields today. With optimization innovation technologies, intricate details concealed within cells are gradually unveiled. The combination scRNA-seq other multi-omics at forefront field. This involves simultaneously measuring various omics data individual cells, expanding our understanding across a broader spectrum dimensions. precisely captures aspects transcriptomes, immune repertoire, spatial information, temporal epitopes, in diverse contexts. In addition to depicting cell atlas normal or diseased tissues, it also provides cornerstone for studying differentiation development patterns, disease heterogeneity, drug resistance mechanisms, treatment strategies. Herein, we review traditional technologies outline latest advancements multi-omics. We summarize current status challenges applying biological clinical applications. Finally, discuss limitations potential strategies address them.
Language: Английский
Citations
21
Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(8), P. 807 - 822
Published: Feb. 3, 2024
The microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms the intratumoral affect tumorigenesis progression, suggesting is a promising biomarker for multiple cancers. low biomass poses major challenge to related research, thus necessitating use multiple-modality integrated framework resolve this dilemma. Advanced techniques such as single-cell sequencing provide significant clues, gradual optimization experiments culture-based methods enables deeper investigation underlying involved. In review, we outline current state research on describe challenges comprehensive strategies future research.
Language: Английский
Citations
18
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 15, 2025
The polymorphic microbiome is considered a new hallmark of cancer. Advances in High-Throughput Sequencing have fostered rapid developments research. interaction between cancer cells, immune and microbiota defined as the immuno-oncology (IOM) axis. Fungal microbes (the mycobiome), although representing only ∼ 0.1-1% microbiome, are critical immunologically active component tumor microbiome. Accumulating evidence suggests possible involvement commensal pathogenic fungi initiation, progression, treatment responsiveness. tumor-associated mycobiome mainly consists gut mycobiome, oral intratumoral mycobiome. However, role remains poorly understood, diversity complexity analytical methods make it challenging to access this field. This review aims elucidate causal complicit roles development progression while highlighting issues that need be addressed executing such We systematically summarize advantages limitations current fungal detection analysis methods. enumerate integrate these recent findings into our understanding accompanied by prospect novel exhilarating clinical implications.
Language: Английский
Citations
3
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Despite significant progress in cancer treatment, traditional therapies still face considerable challenges, including poor targeting, severe toxic side effects, and the development of resistance. Recent advances biotechnology have revealed potential bacteria their derivatives as drug delivery systems for tumor therapy by leveraging biological properties. Engineered bacteria, Escherichia coli, Salmonella, Listeria monocytogenes, along with derivatives─outer membrane vesicles (OMVs), bacterial ghosts (BGs), spores (BSPs)─can be loaded a variety antitumor agents, enabling precise targeting sustained release within microenvironment (TME). These possess intrinsic properties that stimulate immune system, enhancing both innate adaptive responses to further amplify therapeutic effects. The ability naturally accumulate hypoxic regions versatility genetic modifications allow tailored strategies synergistically enhance effectiveness chemotherapy, immunotherapy, targeted therapies. This review comprehensively examines fundamental principles therapy, focusing on employed engineering, loading, use therapy. It also discusses challenges faced optimizing systems, such safety concerns, unintended responses, scalability clinical applications. By exploring these aspects, this provides theoretical framework improving bacterial-based contributing more effective personalized treatments.
Language: Английский
Citations
3
Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217539 - 217539
Published: Feb. 1, 2025
Language: Английский
Citations
2
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: March 24, 2023
Abstract Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for cancers. The growing interest in this area is prominently actuated by the increasing obesity DM prevalence, which partially responsible slight but constant increase pancreatic cancer (PC) occurrence. PC a highly lethal malignancy characterized its insidious symptoms, delayed diagnosis, devastating prognosis. intricate process of promoting involves their local impact pancreas concurrent whole-body systemic changes that are suitable initiation. main mechanisms involved include excessive accumulation various nutrients metabolites directly while also aggravating mutagenic carcinogenic metabolic disorders affecting multiple pathways. Detrimental alterations gastrointestinal sex hormone levels microbiome dysfunction further compromise immunometabolic regulation contribute to establishment an immunosuppressive tumor microenvironment (TME) carcinogenesis, can be exacerbated several crucial pathophysiological processes TME components, such autophagy, endoplasmic reticulum stress, oxidative epithelial-mesenchymal transition, exosome secretion. This review provides comprehensive critical analysis DM-related dissects how impair anticancer immunity influence favor
Language: Английский
Citations
39
Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: July 24, 2023
Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared the localized tumors, current standard-of-care therapies have failed improve survival patients with metastatic PDAC, that necessecitates exploration novel therapeutic approaches. While immunotherapies such as immune checkpoint blockade (ICB) vaccines emerged promising treatment modalities in certain cancers, limited responses been achieved PDAC. Therefore, specific mechanisms regulating response immunotherapy must be explored. The immunosuppressive microenvironment driven by oncogenic mutations, tumor secretome, non-coding RNAs, microbiome persists throughout PDAC progression, allowing neoplastic cells grow locally metastasize distantly. escaping host surveillance are unique molecular, immunological, metabolic characteristics. Following chemokine exosomal guidance, these organ-specific pre-metastatic niches (PMNs) constituted local resident cells, stromal fibroblasts, suppressive metastasis-associated macrophages, neutrophils, myeloid-derived suppressor cells. differs from primary tumors cell composition, functionality, metabolism. Thus far, multiple molecular pathways, distinct identified dampen effector functions, confounding This review describes major immunoregulatory pathways contribute progression limit outcomes Overall, we highlight vulnerabilities attributable factors discuss whether targeting immunological "hot spots" could immunotherapies.
Language: Английский
Citations
39
npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)
Published: Oct. 9, 2023
Abstract Recent evidence suggests that some human cancers may harbor low-biomass microbial ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in this context, are suggested by these studies to localize within cancer cells, immune cells other tumor microenvironment cell types, where they postulated impact multiple cancer-related functions. Herein, we provide an overview of intratumoral while focusing on intracellular their molecular activities, communication networks, host invasion evasion strategies, long-term colonization capacity. We highlight how integration sequencing-based spatial techniques enable recognition bacterial niches. discuss pitfalls, debates challenges decisively proving existence function microbes, reaching a mechanistic elucidation impacts behavior treatment responses. Together, causative understanding possible roles played bacteria future utilization diagnosis, patient stratification, treatment.
Language: Английский
Citations
39