Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: March 13, 2024
The
fifth
edition
of
the
WHO
Classification
Tumors
Central
Nervous
System
(CNS),
published
in
2021,
established
new
approaches
to
both
CNS
tumor
nomenclature
and
grading,
emphasizing
importance
integrated
diagnoses
layered
reports.
This
increased
role
molecular
diagnostics
classification
while
still
relying
on
other
such
as
histology
immunohistochemistry.
Moreover,
it
introduced
types
subtypes
based
novel
diagnostic
technologies
DNA
methylome
profiling.
Over
past
decade,
techniques
identified
numerous
key
genetic
alterations
CSN
tumors,
with
important
implications
regarding
understanding
pathogenesis
but
also
for
prognosis
development
application
effective
molecularly
targeted
therapies.
review
summarizes
major
changes
2021
pediatric
highlighting
each
entity
information
that
are
relevant
diagnostic,
prognostic,
or
therapeutic
purposes
patients’
oncologists’
need
from
a
pathology
report.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(21), P. 15787 - 15787
Published: Oct. 31, 2023
The
Warburg
effect
is
the
long-standing
riddle
of
cancer
biology.
How
does
aerobic
glycolysis,
inefficient
in
producing
ATP,
confer
a
growth
advantage
to
cells?
A
new
evaluation
large
set
literature
findings
covering
and
its
yeast
counterpart,
Crabtree
effect,
led
an
innovative
working
hypothesis
presented
here.
It
holds
that
enhanced
glycolysis
partially
inactivates
oxidative
phosphorylation
induce
functional
rewiring
TCA
cycle
enzymes
generate
non-canonical
metabolic
pathways
sustain
faster
rates.
has
been
structured
by
constructing
two
maps,
one
for
metabolism
other
effect.
New
lines
investigation,
suggested
these
are
discussed
as
instrumental
leading
toward
better
understanding
biology
order
allow
development
more
efficient
metabolism-targeted
anticancer
drugs.
Oncogene,
Journal Year:
2024,
Volume and Issue:
43(12), P. 839 - 850
Published: Feb. 14, 2024
Abstract
Medulloblastoma
is
one
of
the
most
common
malignant
pediatric
brain
tumors
derived
from
posterior
fossa.
The
current
treatment
includes
maximal
safe
surgical
resection,
radiotherapy,
whole
cranio-spinal
radiation
and
adjuvant
with
chemotherapy.
However,
it
can
only
limitedly
prolong
survival
time
severe
side
effects
relapse.
Defining
intratumoral
heterogeneity,
cellular
origin
identifying
interaction
network
within
tumor
microenvironment
are
helpful
for
understanding
mechanisms
medulloblastoma
tumorigenesis
Due
to
technological
limitations,
heterogeneity
have
not
been
fully
understood.
Recently,
emergence
single-cell
technology
has
provided
a
powerful
tool
achieving
goal
tumorigenesis.
Several
studies
demonstrated
each
subtype
utilizing
RNA-seq,
which
uncovered
before
using
conventional
technologies.
In
this
review,
we
present
an
overview
progress
in
discuss
novel
findings
age
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(12)
Published: Dec. 16, 2023
Abstract
Cervical
cancer
(CC)
seriously
affects
women’s
health.
Therefore,
elucidation
of
the
exact
mechanisms
and
identification
novel
therapeutic
targets
are
urgently
needed.
In
this
study,
we
identified
FAM83F,
which
was
highly
expressed
in
CC
cells
tissues,
as
a
potential
target.
Our
clinical
data
revealed
that
FAM83F
protein
expression
markedly
elevated
tissues
positively
correlated
with
poor
prognosis.
Moreover,
observed
knockdown
significantly
inhibited
cell
proliferation,
induced
apoptosis,
suppressed
glycolysis
cells,
while
its
overexpression
displayed
opposite
effects.
Mechanistically,
regulated
growth
by
modulation
Wnt/β-catenin
pathway.
The
enhancing
effects
on
proliferation
could
be
impaired
inhibitor
XAV939.
found
c-Myc
bound
to
promoter
activated
transcription
FAM83F.
Notably,
enhancement
ectopic
c-Myc.
Consistent
vitro
findings,
results
from
xenograft
mouse
model
confirmed
promoting
role
summary,
our
study
demonstrated
promoted
through
regulating
pathway,
suggesting
may
molecular
target
for
treatment.
Cancers,
Journal Year:
2023,
Volume and Issue:
15(2), P. 546 - 546
Published: Jan. 16, 2023
Ferroptosis
exhibits
a
potent
antitumor
effect
and
dihydroorotate
dehydrogenase
(DHODH)
has
recently
been
identified
as
novel
ferroptosis
defender.
However,
the
role
of
DHODH
inhibition
in
cervical
cancer
cells
is
unclear,
particularly
synergy
with
cisplatin
via
ferroptosis.
Herein,
shRNA
brequinar
were
used
to
knock
down
directly
inhibit
DHODH,
respectively.
Immunohistochemistry
Western
blotting
assays
performed
measure
expression
proteins.
CCK-8
colony
formation
employed
assess
cell
viability
proliferation.
was
monitored
through
flow
cytometry,
malondialdehyde
assay
kit
JC-1
staining
analyses.
The
nude
mouse
xenograft
model
generated
examine
combination
on
tumor
growth
vivo.
increased
tissues.
inhibited
proliferation
promoted
cells.
A
synergistically
induced
both
vitro
vivo
downregulated
defender
mTOR
pathway.
Therefore,
synergistic
effects
induction
inhibiting
pathway
could
provide
promising
way
for
therapy.
