CytoJournal, Journal Year: 2024, Volume and Issue: 21, P. 60 - 60
Published: Nov. 30, 2024
Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide. Surfeit 4 (SURF4) member of the surfeit gene family and plays regulatory role in various cellular processes, such as protein transport lipid metabolism. Therefore, this study aims to investigate mechanisms SURF4 OSCC.
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101626 - 101626
Published: March 1, 2025
Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.
Language: Английский
Citations
3
Molecular Aspects of Medicine, Journal Year: 2025, Volume and Issue: 101, P. 101335 - 101335
Published: Jan. 1, 2025
Renal cell carcinoma (RCC) is a malignant tumor with highly heterogeneous and complex molecular mechanisms. Through systematic analysis of TCGA, COSMIC other databases, 24 mutated genes closely related to RCC were screened, including VHL, PBRM1, BAP1 SETD2, which play key roles in signaling pathway transduction, chromatin remodeling DNA repair. The PI3K/AKT/mTOR particularly important the pathogenesis RCC. Mutations such as PIK3CA, MTOR PTEN are associated metabolic abnormalities proliferation. Clinically, mTOR inhibitors VEGF-targeted drugs have shown significant efficacy personalized therapy. Abnormal regulation reprogramming, especially glycolysis glutamine pathways, provides cells continuous energy supply survival advantages, GLS1 promising results preclinical studies. This paper also explores potential immune checkpoint combination targeted drugs, well application nanotechnology drug delivery In addition, unique mechanisms revealed individualized therapeutic strategies explored for specific subtypes TFE3, TFEB rearrangement type SDHB mutant type. review summarizes common gene mutations their mechanisms, emphasizes diagnosis, treatment prognosis, looks forward prospects multi-pathway therapy, immunotherapy treatment, providing theoretical support clinical guidance new development.
Language: Английский
Citations
2
Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(10), P. 2011 - 2022
Published: May 29, 2024
Language: Английский
Citations
13
Endocrine, Journal Year: 2024, Volume and Issue: unknown
Published: June 3, 2024
Abstract Diabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, leading cause of mortality. Recently, cancer become excess hospitalizations, obesity are associated with higher risk developing several types cancer. In this review, we propose that chronic stress significantly increases association. Managing challenging as they significant distress. The relationship between interconnected, anxiety depression being common in patients. Cancer diagnosis treatment lasting changes the body’s neuroendocrine system, causing excessive release catecholamines prostaglandins patients undergoing surgery, promotes spread other parts body. Furthermore, could increase diabetes, or both.
Language: Английский
Citations
9
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104612 - 104612
Published: Jan. 1, 2025
Circular RNAs (circRNAs) have emerged as critical regulators in cancer biology, contributing to various hallmarks, including cell proliferation, apoptosis, metastasis, and drug resistance. Defined by their covalently closed loop structure, circRNAs possess unique characteristics like high stability, abundance, tissue-specific expression. These non-coding function through mechanisms such miRNA sponging, interactions with RNA-binding proteins (RBPs), modulating transcription splicing. Advances RNA sequencing bioinformatics tools enabled the identification functional annotation of across different types. Clinically, demonstrate specificity sensitivity samples, offering potential diagnostic prognostic biomarkers. Additionally, therapeutic strategies involving circRNA mimics, inhibitors, delivery systems are under investigation. However, precise remain unclear, more clinical evidence is needed regarding roles hallmarks. Understanding will pave way for novel approaches, potentially improving patient outcomes.
Language: Английский
Citations
1
Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1924 - 1924
Published: Nov. 20, 2024
Identifying definitive biomarkers that predict clinical response and resistance to immunotherapy remains a critical challenge. One emerging factor is extracellular acidosis in the tumor microenvironment (TME), which significantly impairs immune cell function contributes failure. However, acidic conditions TME disrupt interaction between cancer cells, driving tumor-infiltrating T cells NK into an inactivated, anergic state. Simultaneously, promotes recruitment activation of immunosuppressive such as myeloid-derived suppressor regulatory (Tregs). Notably, acidity enhances exosome release from Tregs, further amplifying immunosuppression. Tumor thus acts "protective shield," neutralizing anti-tumor responses transforming pro-tumor allies. Therefore, targeting lactate metabolism has emerged promising strategy overcome this barrier, with approaches including buffer agents neutralize pH inhibitors block production or transport, thereby restoring efficacy TME. Recent discoveries have identified genes involved (pHe) regulation, presenting new therapeutic targets. Moreover, ongoing research aims elucidate molecular mechanisms acidification develop treatments modulate levels enhance outcomes. Additionally, future studies are crucial validate safety pHe-targeted therapies patients. Thus, review explores regulation pHe its potential role improving immunotherapy.
Language: Английский
Citations
8
Function, Journal Year: 2024, Volume and Issue: 5(3)
Published: Jan. 1, 2024
Abstract The Warburg Effect is a longstanding enigma in cancer biology. Despite the passage of 100 yr since its discovery, and accumulation vast body research on subject, no convincing biochemical explanation has been given for original observations aerobic glycolysis cell metabolism. Here, we have worked out first-principles quantitative analysis problem from principles stoichiometry available electron balance. results interpreted using Nath’s unified theory energy coupling adenosine triphosphate (ATP) synthesis, data colleagues analyzed this new perspective. Use biomass yield based ATP per unit substrate consumed, ${{Y}_{X/S}}\ ATP$, or Nath-Warburg number, NaWa shown to excellently model with very small standard deviation values, without employing additional fitted adjustable parameters. Based analysis, novel conservative mechanism utilization, recycling other key metabolites (eg, lactate) proposed. offers fresh insights into metabolic symbiosis within and/or among proliferating cells. fundamental understanding gained our approach should help catalyzing development more efficient metabolism-targeting anticancer drugs.
Language: Английский
Citations
7
Cancer and Metastasis Reviews, Journal Year: 2024, Volume and Issue: 43(4), P. 1419 - 1443
Published: Sept. 23, 2024
Mitochondria are central actors in diverse physiological phenomena ranging from energy metabolism to stress signaling and immune modulation. Accumulating scientific evidence points the critical involvement of specific mitochondrial-associated events, including mitochondrial quality control, intercellular transfer, genetics, potentiating metastatic cascade neoplastic cells. Furthermore, numerous recent studies have consistently emphasized highly significant role mitochondria play coordinating regulation tumor-infiltrating cells immunotherapeutic interventions. This review provides a comprehensive rigorous scholarly investigation this subject matter, exploring intricate mechanisms by which contribute tumor metastasis examining progress mitochondria-targeted cancer therapies.
Language: Английский
Citations
5
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(6), P. 518 - 532
Published: Jan. 10, 2024
Language: Английский
Citations
4
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 498 - 498
Published: Jan. 9, 2025
The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection metabolism particularly significant, it plays a critical role energy regulation and distribution within organisms. Over recent decades, has emerged relevant focus studies biological regulation, especially following its recognition hallmark cancer. This shift broadened cancer research beyond strictly genetic perspectives. interaction between carcinogenesis involves the essential metabolic pathways, such glycolysis Krebs cycle, well involvement redox-active components like specific amino acids cofactors. feedback mechanisms linking highlight development patterns that enhance flexibility adaptability tumor processes, influencing larger-scale phenomena circadian rhythms epigenetics.
Language: Английский
Citations
0