Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
A
visible-light
induced
intermolecular
hydroamination
of
alkenes
with
azoles
is
reported,
delivering
pharmaceutically
valuable
N-benzyl
in
high
yields
excellent
Markovnikov
selectivity.
Mechanistic
studies
suggest
that
the
process
initiated
by
energy
transfer
excited
photocatalyst
alkenes,
followed
single
electron
reduction,
protonation,
and
subsequent
oxidation
to
afford
key
alkyl
carbocation
intermediate.
This
protocol
exhibits
advantages
broad
functional
group
tolerance,
atom
economy,
efficiency,
mild
reaction
conditions.
Energy & Environmental Science,
Journal Year:
2024,
Volume and Issue:
17(13), P. 4426 - 4460
Published: Jan. 1, 2024
The
practical
application
of
commercialized
lithium-ion
batteries
(LIBs)
currently
faces
challenges
due
to
using
liquid
electrolytes
(LEs),
including
limited
energy
density
and
insufficient
safety
performance.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(20), P. 7971 - 7977
Published: Jan. 1, 2023
Alkyl
diacyl
peroxides
were
demonstrated
to
be
efficient
alkylating
reagents
for
the
visible-light-induced
4CzIPN-catalyzed
direct
C–H
alkylation
of
N
-heteroaromatics.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(24), P. 4598 - 4602
Published: June 12, 2023
A
novel
radical
cascade
trifluoromethylthiolation/cyclization
of
dienes
(N-alkyl-2-(1-phenylvinyl)aniline
derivatives)
with
AgSCF3
has
been
developed.
This
approach
provides
simple
and
efficient
access
to
a
wide
range
SCF3-containing
medium-sized
rings
(7/8/9-membered
heterocycles).
Preliminary
mechanistic
studies
suggest
that
the
reaction
is
realized
through
silver-assisted
cyclization
process.
The
large-scale
experiment
modification
product
reveal
promising
utility
this
protocol.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 9078 - 9085
Published: June 3, 2024
The
α-C–H
trifluoromethylthiolation
of
N,N-disubstituted
enaminones
has
been
achieved
with
simple
and
cheap
CF3SO2Na
as
the
CF3S
source.
reactions
were
run
at
mild
temperature
(0
°C
to
rt)
using
POCl3
only
reducing
reagent.
work
represents
first
example
on
synthesis
α-trifluoromethylthio
via
direct
C–H
functionalization.
In
addition,
resulting
CF3S-functionalized
have
proven
useful
building
blocks
in
various
heteroaromatic
compounds
by
annulation
reactions.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(18), P. 3210 - 3215
Published: April 28, 2023
Herein,
we
have
developed
a
metal-free,
Lewis
acid
promoted
vicinal
oxytrifluoromethylselenolation
of
alkenes
using
trifluoromethyl
selenoxides
as
electrophilic
trifluoromethylselenolation
reagents
and
alcohols
nucleophiles.
With
less
steric
good
nucleophilic
solvents
(such
ethanol
methol),
Tf2O-catalyzed
could
be
realized,
while
stoichiometric
Tf2O
was
required
to
promote
full
transformation
with
isopropanol
tert-butanol).
The
reaction
featured
substrate
scope,
functional
group
compatibility,
diastereoselectivity.
This
method
further
applied
oxytrifluoromethylselenolation,
aminotrifluoromethylselenolation
nucleophiles
under
modified
conditions.
A
mechanism
involving
seleniranium
ion
proposed
based
on
the
preliminary
results.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: June 1, 2024
Isatins
have
been
widely
used
in
the
preparation
of
a
variety
heterocyclic
compounds,
where
skeletal
editing
isatins
has
shown
significant
advantages
for
construction
diverse
heterocycles.
This
review
highlights
progress
made
last
decade
(2013-2023)
isatin
scaffold.
A
series
ring
expansion
reactions
quinoline
skeleton,
quinolone
polycyclic
quinazoline
medium-sized
as
well
opening
generation
2-(azoly)aniline
skeleton
by
cleavage
C-C
bond
and
C-N
are
highlighted.
It
is
hoped
that
this
will
provide
some
understanding
chemical
transformations
contribute
to
further
realization
its
molecular
diversity.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(42), P. 6367 - 6370
Published: Jan. 1, 2023
An
efficient
protocol
has
been
developed
herein
for
the
site-selective
alkylation
of
silyl
enol
ethers
with
arylsulfonium
salts
giving
access
to
valuable
aryl
alkyl
thioethers
under
visible
light
conditions.
Enabled
by
copper
(I)
photocatalysis,
C-S
bond
can
be
selectively
cleaved
deliver
C-centered
radicals
mild
This
method
provides
a
straightforward
approach
utilize
as
sulfur
sources
synthesis
thioethers.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(22), P. 15969 - 15974
Published: Oct. 30, 2023
Described
herein
is
a
photoinduced
copper-catalyzed
1,2-difunctionalization
of
1,3-dienes.
The
selenium
atom
radical
was
generated
by
the
visible
light
irradiation
diselenides,
triggering
addition
with
1,3-dienes
to
form
allyl
intermediate.
Subsequent
rapid
Z/E
isomerization
allowed
for
thermodynamically
favorable
intermediate
formation
and
enabled
copper
catalyzed
stereoselective
functionalization
various
nucleophiles.
