Progress on iron-series metal-organic frameworks materials towards electrocatalytic hydrogen evolution reaction

Surfaces and Interfaces, Journal Year: 2023, Volume and Issue: 42, P. 103368 - 103368

Published: Sept. 9, 2023

Language: Английский

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Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(8), P. 1684 - 1693

Published: Jan. 1, 2023

2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.

Language: Английский

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Synergistic Interaction between Metal Single‐Atoms and Defective WO_3−x Nanosheets for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: Feb. 27, 2024

Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited obtain SA‐decorated nanocomposites (M‐WO ). Importantly, Cu‐WO sonosensitizer exhibits much higher activity ultrasound (US)‐induced production reactive species than that Cu , which also M‐WO nanosheets. Both experimental theoretical results suggest excellent performance should be attributed between OVs. Therefore, after polyethylene glycol modification, can quickly kill cancer cells in vitro effectively eradicate tumors vivo US irradiation. Transcriptome sequencing analysis further molecular validation ‐mediated SDT‐activated apoptosis TNF signaling pathways potential drivers tumor induction.

Language: Английский

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Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO_2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Language: Английский

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CuS/Co-Ferrocene-MOF Nanocomposites for Photothermally Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 10998 - 11007

Published: April 29, 2024

Infections caused by bacteria pose a serious threat to public health, and there is need for numerous innovative, antibiotic-free antimicrobial medicines. Herein, we describe the synthesis of CuS/Co-ferrocene-MOF (CuS/Co-Fc-MOF) nanocomposites, formed coupling CuS nanoparticles (NPs) two-dimensional (2D) Co-Fc-MOF nanosheets, that constitutes an platform capable near-infrared (NIR) photothermal promotion chemodynamic antibacterial. 2D CuS/Co-Fc-MOF nanocomposites consist nanosheets with dimensions approximately 100–200 nm thicknesses 13.1–15.6 nm, where NPs, size about 8 are excellently dispersed on surface nanosheets. The diverse valence states cobalt iron in enable them undergo Fenton-like reactions H2O2, thus generating highly oxidizing ·OH therapy (CDT). utilization local plasmonic resonance effect NPs enables enhancement CDT activity under laser irradiation. More importantly, can achieve rapid (15 min) NIR laser-assisted killing both S. aureus E. coli bacterial infection microenvironment compared Therefore, be employed as promising nanoagent promote photothermally augmented antibacterial therapy.

Language: Английский

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Encapsulation engineering of porous crystalline frameworks for delayed luminescence and circularly polarized luminescence

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(13), P. 6694 - 6734

Published: Jan. 1, 2024

Delayed luminescence (DF), including phosphorescence and thermally activated delayed fluorescence (TADF), circularly polarized (CPL) exhibit common broad application prospects in optoelectronic displays, biological imaging, encryption. Thus, the combination of is attracting increasing attention. The encapsulation guest emitters various host matrices to form host-guest systems has been demonstrated be an appealing strategy further enhance and/or modulate their luminescence. Compared with conventional liquid crystals, polymers, supramolecular matrices, porous crystalline frameworks (PCFs) metal-organic (MOFs), covalent-organic (COFs), zeolites hydrogen-bonded organic (HOFs) can not only overcome shortcomings such as flexibility disorder but also achieve ordered guests long-term stability chiral structures, providing new promising platforms for development DF CPL. In this review, we provide a comprehensive critical summary recent progress photochemistry

Language: Английский

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Construction of PCN-222@PCN-134 as sorbent of dispersive solid-phase extraction for extraction and enrichment of sulphonamides

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: 342, P. 127055 - 127055

Published: March 9, 2024

Language: Английский

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Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: June 22, 2024

Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.

Language: Английский

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Biophilic Positive Carbon Dot Exerts Antifungal Activity and Augments Corneal Permeation for Fungal Keratitis

Nano Letters, Journal Year: 2024, Volume and Issue: 24(13), P. 4044 - 4053

Published: March 22, 2024

Fungal keratitis (FK) is an infectious eye disease that poses a significant risk of blindness. However, the effectiveness conventional antifungal drugs limited due to intrinsic ocular barrier impedes drug absorption. There urgent need develop new therapeutic strategies effectively combat FK. Herein, we synthesized ultrasmall positively charged carbon dot using simple stage-melting method. The can penetrate corneal by opening tight junctions, allowing them reach lesion site and kill fungi. results both in vitro vivo demonstrated it exhibited good biocompatibility activity, significantly improving effect mouse model Therefore, this biophilic size positive dot, characterized its ability properties, may offer valuable insights into design effective nanomedicines.

Language: Английский

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Carbon-based electrocatalysts for hydrogen evolution reaction

Energy Conversion and Management X, Journal Year: 2025, Volume and Issue: unknown, P. 100892 - 100892

Published: Jan. 1, 2025

Language: Английский

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