Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(11), P. 3873 - 3926

Published: Jan. 1, 2023

Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive oxygen species (ROS), reactive nitrogen (RNS), and sulfur (RSS) are direct participants important biomarkers oxidative stress.

Language: Английский

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Recent progress on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl−)

Dyes and Pigments, Journal Year: 2022, Volume and Issue: 200, P. 110132 - 110132

Published: Jan. 28, 2022

Language: Английский

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Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 486, P. 215130 - 215130

Published: April 10, 2023

Language: Английский

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Recent advances in small-molecule fluorescent probes for studying ferroptosis

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(18), P. 7752 - 7778

Published: Jan. 1, 2022

Ferroptosis is an iron-dependent, non-apoptotic form of programmed cell death driven by excessive lipid peroxidation (LPO). Mounting evidence suggests that the unique modality involved in development and progression several diseases including cancer, cardiovascular (CVDs), neurodegenerative disorders, etc. However, pathogenesis signalling pathways ferroptosis are not fully understood, possibly due to lack robust tools for highly selective sensitive imaging analytes complex living systems. Up now, various small-molecule fluorescent probes have been applied as promising chemosensors studying through tracking biomolecules or microenvironment-related parameters vitro vivo. In this review, we comprehensively reviewed recent ferroptosis, with a focus on analytes, design strategies bioimaging applications. We also provided new insights overcome major challenges emerging field.

Language: Английский

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A two-pronged detection of atherosclerosis with a dual-channel fluorescent probe for viscosity and hypochlorous acid

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 464, P. 142687 - 142687

Published: March 29, 2023

Language: Английский

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A novel fluorescent probe for cascade detection of hydrogen sulfide and hypochlorous acid and its application in bioimaging

Talanta, Journal Year: 2024, Volume and Issue: 270, P. 125649 - 125649

Published: Jan. 8, 2024

Language: Английский

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NIR-II-excited off-on-off fluorescent nanoprobes for sensitive molecular imaging in vivo

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 2, 2025

Strong background interference signals from normal tissues have significantly compromised the sensitive fluorescence imaging of early disease with exogenous probes in vivo, particularly for liver due to liver's significant uptake and accumulation nanoprobes, coupled high tissue autofluorescence deep depth. As a proof-of-concept study, we herein report near-infrared-II (NIR-II, 1.0-1.7 μm) light-excited "off-on-off" NIR-II fluorescent probe (NDP). It has near-ideal zero initial but can turn on its cancer then off again upon migration minimize interference. Due low background, blind study employing our could identify female mice orthotopic tumors 100% accuracy mixed subjects healthy tumor mice, implemented locating sizes as small 4 mm. Our NIR-II-excited design concept not only provides promising molecular guideline also be generalized other lesions. Background compromise vivo. Here, authors Near-infrared-II excited ''off-on-off" focus events occurring diffusion activated tumors.

Language: Английский

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Development of a novel fluorescent probe for the detection of glyphosate in food and water samples and the construction of a smartphone-assisted platform

Food Chemistry, Journal Year: 2025, Volume and Issue: 474, P. 143045 - 143045

Published: Jan. 23, 2025

Language: Английский

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A Dual-Channel Fluorescence Probe for Early Diagnosis and Treatment Monitoring of Acute Kidney Injury by Detecting HOCl and Cys with Different Fluorescence Signals

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

The pathogenesis of acute kidney injury (AKI) is a multifaceted process involving various mechanisms, with oxidative stress playing crucial role in its development. Hypochlorite (HOCl) and cysteine (Cys) are indicators AKI pathophysiology, directly reflecting the degree disease severity. However, their exact mechanism action pathophysiology remains unknown. Herein, we developed dual-channel fluorescent probe, MB-NAP, which allowed for simultaneous detection HOCl Cys. probe exhibited distinct fluorescence responses green channel (λex = 450 nm, λem 560 nm) red 610 690 nm), without any spectral crosstalk, allowing accurate measurement both analytes. We successfully applied MB-NAP to monitor levels Cys cellular vivo models AKI, revealing significant increase concentrations compared normal models. Furthermore, was demonstrated exhibit outstanding capabilities drug screening by effectively real-time monitoring This study not only provides more sensitive reliable method/tool tracking AKI-related pathological processes but also offers potential breakthrough early diagnosis identification therapeutic agents aimed at mitigating stress-induced damage AKI.

Language: Английский

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A novel AIRE-based fluorescent ratiometric probe with endoplasmic reticulum-targeting ability for detection of hypochlorite and bioimaging

Bioorganic Chemistry, Journal Year: 2022, Volume and Issue: 131, P. 106319 - 106319

Published: Dec. 15, 2022

Language: Английский

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