Coordination Chemistry Reviews,
Journal Year:
2022,
Volume and Issue:
462, P. 214508 - 214508
Published: March 29, 2022
The
cell
contains
various
organelles
that
perform
different
functions
using
biological
processes
to
form
a
complete
organic
architecture.
Healthy
cells
and
tumor
often
show
clear
differences
in
cellular
homeostasis.
Specific
detection,
imaging,
therapeutic
strategies
targeting
have
been
found
be
effective
for
diagnosis
therapy.
multiple
of
AIEgens
make
them
attractive
over
other
nanomaterials,
the
application
has
increased
dramatically
tumor-related
nanomedicine,
specifically,
bioimaging,
therapy
cancers.
Here,
recent
advances
AIEgen
applications
specific
are
summarized.
ability
target
enhanced
diagnostic
this
technology,
review
will
provide
guidance
further
exploration
AIEgen-related
nanomedicine.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(35)
Published: June 30, 2022
Instant
visualization
of
latent
fingerprints
is
developed
by
using
a
series
water-soluble
terpyridine
zinc
complexes
as
aggregation-induced
emission
probes
in
pure
water,
under
UV
light
or
ambient
sunlight.
By
simply
soaking,
spraying
with
an
aqueous
solution
the
probe,
bright
yellow
fluorescence
images
high
contrast
and
resolution
are
readily
on
various
surfaces
including
tinfoil,
glass,
paper,
steel,
leather,
ceramic
tile.
Remarkably,
can
be
visualized
within
seconds
details
whorl
sweat
pores.
The
color
tuned
from
blue
to
orange
modifying
pincer
ligands,
allowing
direct
imaging
These
inexpensive,
water-resistant,
color-tunable
provide
practical
approach
for
recording
analysis,
security
protection,
well
criminal
investigation
different
scenarios.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(4), P. 5932 - 5942
Published: March 28, 2022
Organelle-specific
imaging
and
dynamic
tracking
in
ultrahigh
resolution
is
essential
for
understanding
their
functions
biological
research,
but
this
remains
a
challenge.
Therefore,
facile
strategy
by
utilizing
anion-π+
interactions
proposed
here
to
construct
an
aggregation-induced
emission
luminogen
(AIEgen)
of
DTPAP-P,
not
only
restricting
the
intramolecular
motions
also
blocking
strong
π-π
interactions.
DTPAP-P
exhibits
high
photoluminescence
quantum
yield
(PLQY)
35.04%
solids,
favorable
photostability
biocompatibility,
indicating
its
potential
application
super-resolution
(SRI)
via
stimulated
depletion
(STED)
nanoscopy.
It
observed
that
cationic
can
specifically
target
mitochondria
or
nucleus
dependent
on
cell
status,
resulting
tunable
organelle-specific
nanometer
scale.
In
live
cells,
mitochondria-specific
monitoring
(fission
fusion)
be
obtained
with
full-width-at-half-maximum
(fwhm)
value
165
nm
STED
This
about
one-sixth
fwhm
confocal
microscopy
(1028
nm).
However,
migration
process
occurs
fixed
cells
from
under
light
activation
(405
nm),
leading
nucleus-targeted
(fwhm=
184
These
findings
indicate
single
AIEgen
at
superior
achieved
our
case
nanoscopy,
thus
providing
efficient
method
further
understand
organelle's
roles
research.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
62(1)
Published: Sept. 30, 2022
Decoding
cellular
processes
requires
visualization
of
the
spatial
distribution
and
dynamic
interactions
biomolecules.
It
is
therefore
not
surprising
that
innovations
in
imaging
technologies
have
facilitated
advances
biomedical
research.
The
advent
super-resolution
has
empowered
researchers
with
ability
to
answer
long-standing
questions
about
at
an
entirely
new
level.
Fluorescent
probes
greatly
enhance
specificity
resolution
experiments.
Here,
we
introduce
key
technologies,
a
brief
discussion
on
single-molecule
localization
microscopy
(SMLM).
We
evaluate
chemistry
photochemical
mechanisms
fluorescent
employed
SMLM.
This
Review
provides
guidance
identification
adoption
single
molecule
inspire
design
next-generation
amenable
imaging.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(33)
Published: June 26, 2023
The
low
oxygen
dependence
of
type
I
photosensitizers
(PSs)
has
made
them
a
popular
choice
for
treating
solid
tumors.
However,
the
drawbacks
poor
water
solubility,
short
emission
wavelength,
stability,
and
inability
to
distinguish
cancer
cells
from
normal
limit
application
most
PSs
in
clinical
therapy.
Thereby,
developing
novel
overcoming
these
problems
is
an
urgent
but
challenging
task.
Herein,
by
utilizing
distinctive
structural
characteristics
anion-π+
interactions,
highly
water-soluble
PS
(DPBC-Br)
with
aggregation-induced
(AIE)
characteristic
near-infrared
(NIR)
fabricated
first
time.
DPBC-Br
displays
remarkable
solubility
(7.3
mM)
outstanding
photobleaching
resistance,
enabling
efficient
precise
differentiation
between
tumor
wash-free
long-term
tracking
manner
via
NIR-I
imaging.
Additionally,
superior
reactive
species
(ROS)
produced
provide
both
specific
killing
vitro
inhibition
growth
vivo,
negligible
systemic
toxicity.
This
study
rationally
constructs
PS,
which
higher
reliability
controllability
compared
conventional
nanoparticle
formulating
procedures,
offering
great
potential
treatment.
The Journal of Physical Chemistry C,
Journal Year:
2022,
Volume and Issue:
126(5), P. 2896 - 2904
Published: Jan. 26, 2022
Aggregation-induced
emission
(AIE)
has
been
significantly
explored
to
enhance
luminescence
properties.
Here,
we
synthesized
bimetallic
AuCu
nanoclusters
(NCs)
and
studied
their
AIE
by
reconstructing
the
surface
motif
from
−S–Au(I)–S–
Au(I)–S–
−S–Au(I)–S–Cu(I)–S–,
as
evident
X-ray
photoelectron
spectroscopy
(XPS)
microscopy
studies.
A
significant
blue
shift
in
band
of
Au
NCs
is
observed
with
change
Au/Cu
molar
ratio.
We
enormous
enhancement
decreasing
temperature
due
suppression
intramolecular
motion
ligands.
200-fold
occurs
aggregation
ultrasmall-sized
a
less
polar
medium
water–ethanol
mixture.
An
increase
radiative
rate
supports
effect
Au(I)–Cu(I)
metallophilic
interaction.
decrease
nonradiative
confirms
restriction
ligand
motions
aggregated
state.
Metal
cluster-based
AIE-type
materials
pave
way
design
highly
luminescent
for
potential
applications
sensing,
biolabeling,
light-emitting
diodes
(LEDs),
other
fields.
