Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 1, 2025
Despite
the
success
in
exploring
various
aspects
of
origination
and
therapeutic
strategies,
cancer
has
remained
one
most
dreadful
metabolic
disorders
due
to
failure
eradicate
tumors
comprehensively
frequent
recurrence
because
acquired
resistance
drugs.
Recently,
several
advancements
have
been
evidenced
fabrication
smart
nanocarriers
encapsulated
with
multiple
components.
Several
reasons
for
nanoencapsulation
include
enhancement
bioavailability
drugs,
precise
targetability
reduce
adverse
effects
on
normal
cells,
ability
enable
controlled
drug
release
rates
at
tumor
sites.
In
addition,
these
protect
cargo
from
deactivation,
responsively
delivering
it
based
physiological
or
pathological
characteristics
tumors.
this
review,
we
present
approaches
therapy,
including
organic
materials,
inorganic
components,
their
composites,
as
well
biomembrane-based
strategies.
These
along
practical
applications
potential
treatment,
are
discussed
depth,
highlighting
advantages
disadvantages,
aiming
reveal
ultimate
prospects
enhancing
delivery
efficiency
targeted
therapy.
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
8, P. 100281 - 100281
Published: Aug. 28, 2024
Cancer
is
the
leading
cause
of
death
globally,
and
conventional
treatments
have
limited
efficacy
with
severe
side
effects.
The
use
nanotechnology
has
potential
to
reduce
effects
drugs
by
creating
efficient
controlled
anticancer
drug
delivery
systems.
Nanoparticles
(NPs)
used
as
carriers
offer
several
advantages,
including
enhanced
protection,
biodistribution,
selectivity
and,
pharmacokinetics.
Therefore,
this
review
devoted
various
organic
(lipid,
polymeric)
well
inorganic
nanoparticles
based
on
different
building
units
providing
a
wide
range
potent
Within
these
nanoparticulate
systems,
chitosan
(CS)-based
NPs
are
discussed
particular
emphasis
due
unique
properties
CS
its
derivatives
non-toxicity,
biodegradability,
mucoadhesivity,
tunable
physico-chemical
biological
allowing
their
alteration
specifically
target
cancer
cells.
In
context
streamlining
systems
(DDS),
innovative
nanoplatform-based
therapy
pathways
involving
passive
active
targeting
stimuli-responsive
DDS
enhancing
overall
orthogonality
developed
NP-DDS
towards
included.
most
up-to-date
information
delivering
anti-cancer
using
modern
dosage
forms
specifically,
CSNPs,
summarised
evaluated
concerning
benefits,
limitations,
advanced
applications.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(1), P. 88 - 88
Published: Jan. 9, 2024
Clinical
drug
administration
aims
to
deliver
drugs
efficiently
and
safely
target
tissues,
organs,
cells,
with
the
objective
of
enabling
their
therapeutic
effects.
Currently,
main
approach
enhance
a
drug’s
effectiveness
is
ensuring
its
efficient
delivery
intended
site.
Due
fact
that
there
are
still
various
drawbacks
traditional
methods,
such
as
high
toxicity
side
effects,
insufficient
specificity,
poor
targeting,
pharmacokinetic
performance,
nanocarriers
have
emerged
promising
alternative.
Nanocarriers
possess
significant
advantages
in
due
size
tunability
surface
modifiability.
Moreover,
nano-drug
systems
demonstrated
strong
potential
terms
prolonging
circulation
time,
improving
bioavailability,
increasing
retention
at
tumor
site,
decreasing
resistance,
well
reducing
undesirable
effects
anticancer
drugs.
Numerous
studies
focused
on
utilizing
polysaccharides
nanodelivery
carriers,
developing
based
polysaccharides,
or
exploiting
tumor-targeting
ligands
precision
nanoparticle
delivery.
These
types
investigations
become
commonplace
academic
literature.
This
review
elucidate
preparation
methods
principles
polysaccharide
gold
nanocarriers.
It
also
provides
an
overview
factors
affect
loading
different
kinds
Additionally,
it
outlines
strategies
employed
by
improve
efficiency
The
provide
reference
for
further
development
research
systems.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 19, 2024
The
biomimetic
nanoparticles
(NPs)
possessing
abilities
of
tumor
targeting
and
multimodal
therapy
show
great
potential
for
efficient
combat
colon
cancer.
Herein,
we
developed
a
multifunctional
nanoplatform
(Fe
