pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 3194 - 3207

Published: Jan. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Language: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Journal Year: 2021, Volume and Issue: 15(12), P. 18895 - 18930

Published: Dec. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Language: Английский

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Antibacterial biomaterials for skin wound dressing

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(3), P. 353 - 384

Published: Jan. 24, 2022

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.

Language: Английский

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(8), P. 13022 - 13036

Published: Aug. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Language: Английский

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Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing

Bioactive Materials, Journal Year: 2023, Volume and Issue: 30, P. 129 - 141

Published: July 28, 2023

In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. this study, series adhesive conductive antibacterial hydrogel based on oxidized sodium alginate-grafted dopamine/carboxymethyl chitosan/Fe3+ (OSD/CMC/Fe hydrogel)/polydopamine-encapsulated poly(thiophene-3-acetic acid) (OSD/CMC/Fe/PA hydrogel) were prepared for the repair infected wound. The Schiff base and Fe3+ coordination bonds structure are dynamic can be repaired automatically after network disrupted. Macroscopically, exhibits properties, allowing dressing adapt complex surfaces. OSD/CMC/Fe/PA showed conductivity photothermal properties under near-infrared (NIR) light irradiation. addition, hydrogels exhibit tunable rheological suitable mechanical antioxidant tissue adhesion hemostatic Furthermore, all improved healing in full-thickness defect skin test mice. size by OSD/CMC/Fe/PA3 + NIR was much smaller (12%) than control group treated Tegaderm™ film 14 days. conclusion, have high efficiency, conductivity, great biocompatibility, hemostasis making them promising candidates treatment wounds.

Language: Английский

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Bioinspired Injectable Self-Healing Hydrogel Sealant with Fault-Tolerant and Repeated Thermo-Responsive Adhesion for Sutureless Post-Wound-Closure and Wound Healing

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: Sept. 13, 2022

Hydrogels with multifunctionalities, including sufficient bonding strength, injectability and self-healing capacity, responsive-adhesive ability, fault-tolerant repeated tissue adhesion, are urgently demanded for invasive wound closure healing. Motivated by the adhesive mechanism of mussel brown algae, bioinspired dynamic bonds cross-linked multifunctional hydrogel is designed based on sodium alginate (SA), gelatin (GT) protocatechualdehyde, ferric ions added, sutureless post-wound-closure. The through Schiff base bond, catechol-Fe coordinate bond strong interaction between GT temperature-dependent phase transition SA, endows resulting mechanical strength efficient closure, reopened wounds. Moreover, properties endowed mispositioning to be removed/repositioned, which conducive adhesion adhesives during surgery. Besides, hydrogels present good biocompatibility, near-infrared-assisted photothermal antibacterial activity, antioxidation thermo-responsive reversible hemostatic effect. in vivo incision evaluation demonstrated their capability promote post-wound-closure healing incisions, indicating that developed dressing could serve as versatile sealant.

Language: Английский

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Infant Skin Friendly Adhesive Hydrogel Patch Activated at Body Temperature for Bioelectronics Securing and Diabetic Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 8662 - 8676

Published: May 13, 2022

Adhesive-caused injury is a great threat for infants with premature skin or diabetic patients fragile because extra-strong adhesion might incur pain, inflammation, and exacerbate trauma upon removal. Herein, we present skin-friendly adhesive hydrogel patch based on protein–polyphenol complexation strategy, which leads to thermoresponsive network sensitive body temperature. The of the smartly activated after contacting warm skin, whereas painless detachment easily realized by placing an ice bag surface hydrogel. exhibits immunomodulatory performance that prevents irritation allergic reactions during long-period contact skin. Thus, works as conformable nonirritating interface guarantee nondestructively securing bioelectronics infant healthcare. Furthermore, provides gentle wounded favorable environment speed up healing process managing wounds.

Language: Английский

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All-in-one: Harnessing multifunctional injectable natural hydrogels for ordered therapy of bacteria-infected diabetic wounds

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135691 - 135691

Published: March 9, 2022

Language: Английский

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All‐Natural Immunomodulatory Bioadhesive Hydrogel Promotes Angiogenesis and Diabetic Wound Healing by Regulating Macrophage Heterogeneity

Advanced Science, Journal Year: 2023, Volume and Issue: 10(13)

Published: March 2, 2023

Abstract Macrophages are highly heterogeneous and exhibit a diversity of functions phenotypes. They can be divided into pro‐inflammatory macrophages (M1) anti‐inflammatory (M2). Diabetic wounds characterized by prolonged inflammatory phase difficulty in healing due to the accumulation wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise promoting diabetic wound clinical applications. However, precise conversion M1 M2 simple biosafe approaches is still challenge. Here, an all‐natural ability regulate developed promote angiogenesis healing. The protocatechuic aldehyde hybridized collagen‐based exhibits good bioadhesive antibacterial properties as well reactive oxygen species scavenging ability. More importantly, able convert without need for any additional ingredients or external intervention. This safe immunomodulatory approach shows application potential shortening repair accelerating

Language: Английский

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Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure

Science Advances, Journal Year: 2023, Volume and Issue: 9(33)

Published: Aug. 16, 2023

Tissue adhesives have garnered extensive interest as alternatives and supplements to sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate biocompatibility, uncontrolled biodegradation. Here, injectable biocompatible hydrogel are developed via catalyst-free o-phthalaldehyde/amine (hydrazide) cross-linking reaction. The hydrogels demonstrate rapid firm adhesion various tissues, an o-phthalaldehyde-mediated mechanism is established. show controlled degradation profiles of 6 22 weeks in vivo through the incorporation disulfide bonds into network. In liver blood vessel injury, effectively seal incisions rapidly stop bleeding. rat rabbit models full-thickness skin incision, quickly close accelerate wound healing, which exhibit efficacies superior those commercially available fibrin glue cyanoacrylate glue. Thus, great potential for sutureless closure, hemostasis sealing, prevention leakage surgical applications.

Language: Английский

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