3D printing of stimuli-responsive hydrogel materials: Literature review and emerging applications

Giant, Journal Year: 2023, Volume and Issue: 17, P. 100209 - 100209

Published: Nov. 15, 2023

Additive manufacturing (AM) aka three-dimensional (3D) printing has been a well-established and unparalleled technology, which is expanding the boundaries of materials science exhibiting an enormous potential to fabricate intricate geometries for healthcare, electronics, construction sectors. In contemporary era, combination AM technology stimuli-responsive hydrogels (SRHs) helps create dynamic functional structures with extreme accuracy, are capable changing their shape, functional, or mechanical properties in response environmental cues such as humidity, heat, light, pH, magnetic field, electric etc. 3D SRHs permits creation on-demand dynamically controllable shapes excellent control over various self-repair, self-assembly, multi-functionality, These accelerate researchers think unthinkable applications. Additively manufactured objects have shown applications like tissue engineering, drug delivery, soft robots, sensors, other biomedical devices. The current review provides recent progress SRHs, more focus on techniques, stimuli mechanisms, shape morphing behaviors, Finally, trends future roadmap additively smart different also presented, will be helpful research. This holds great promise providing fundamental knowledge about diverse

Language: Английский

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Rheology as a Tool for Fine-Tuning the Properties of Printable Bioinspired Gels

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2766 - 2766

Published: March 19, 2023

Over the last decade, efforts have been oriented toward development of suitable gels for 3D printing, with controlled morphology and shear-thinning behavior in well-defined conditions. As a multidisciplinary approach to fabrication complex biomaterials, bioprinting combines cells biocompatible materials, which are subsequently printed specific shapes generate structures regenerative medicine or tissue engineering. A major interest is devoted printing biomimetic materials structural fidelity after their fabrication. Among some requirements imposed bioinks, such as biocompatibility, nontoxicity, possibility be sterilized, nondamaging processability represents critical issue stability functioning constructs. The challenges field printable mimic at different length scales existing nature reproduce functions biological systems. Thus, careful investigation rheological characteristics allows fine-tuning material properties that manufactured targeted applications. fluid-like solid-like conditions similar those encountered additive manufacturing can monitored through viscoelastic parameters determined shear network strength, shear-thinning, yield point, thixotropy govern bioprintability. An assessment these features provides significant insights design characterization gels. This review focuses on bioinspired survey cutting-edge research developing manufacturing.

Language: Английский

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Application of polyvinyl alcohol/chitosan copolymer hydrogels in biomedicine: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 125192 - 125192

Published: June 3, 2023

Language: Английский

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Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Abstract Successful wound healing is a process that has three overlying phases: inflammatory, proliferative and remodeling. Chronic wounds are characterized by perpetuated inflammation inhibits the remodeling phases impairs healing. Macrophages key modulators of process. Initially, they responsible for cleaning phagocytosis pathogens afterwards lead to resolution inflammatory response express growth factors important angiogenesis cytokines needed cell proliferation deposition extracellular matrix. The phenotype macrophage changes gradually throughout from initial M1 pro-inflammatory characteristic acute M2 pro-regenerative allows an accurate tissue repair. In chronic wounds, macrophages persist impair As such, immunomodulatory biomaterials arise as promising solutions accelerate this review, we discuss importance their polarization different healing; dysfunction in use overcome critical problem wounds—the continued phase

Language: Английский

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Self-healing hydrogels for bone defect repair

RSC Advances, Journal Year: 2023, Volume and Issue: 13(25), P. 16773 - 16788

Published: Jan. 1, 2023

Self-healing hydrogels respond rapidly, autonomously, and repeatedly to induced damage can maintain their original properties. This review focuses on applications in bone defect repair we discussed the recent progress this field.

Language: Английский

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Bioinspired Supramolecular Hydrogel from Design to Applications

Small Methods, Journal Year: 2023, Volume and Issue: 8(4)

Published: Aug. 20, 2023

Nature offers a wealth of opportunities to solve scientific and technological issues based on its unique structures function. The dynamic non-covalent interaction is considered be the main base living functions creatures including humans, animals, plants. Supramolecular hydrogels formed by bonding interactions has become platform for constructing promising materials medicine, energy, electronic, biological substitute. In this review, self-assemble principle supramolecular summarized. Next, stimulation external environment that triggers assembly or disassembly are recapitulated, temperature, mechanics, light, pH, ions, etc. applications bioinspired in terms bionic objects plants also described. Although so many efforts done revealing synergized mechanism function hydrogel, complexity variability between stimulus system still require impeccable theories. As an outlook, hydrogel just beginning exhibit great potential human life, offering significant drug delivery screening, implantable devices substitutions, tissue engineering, micro-fluidic devices, biosensors.

Language: Английский

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Recent Insights into Glucose-Responsive Concanavalin A-Based Smart Hydrogels for Controlled Insulin Delivery

Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 260 - 260

Published: April 11, 2024

Many efforts are continuously undertaken to develop glucose-sensitive biomaterials able of controlling glucose levels in the body and self-regulating insulin delivery. Hydrogels that swell or shrink as a function environmental free content suitable systems for monitoring blood glucose, delivering doses adapted concentration. In this context, development sensors based on reversible binding molecules represents continuous challenge. Concanavalin A (Con A) is bioactive protein isolated from sword bean plants (Canavalia ensiformis) contains four sugar-binding sites. The high affinity reversibly specifically mannose makes Con natural receptor smart glucose-responsive materials. During last few years, was used materials, such hydrogels, microgels, nanoparticles films, producing biosensors drug delivery devices. This review focused A-based materials diagnosis therapeutics diabetes. brief outlook glucose-derived theranostics cancer also presented.

Language: Английский

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Biomaterials-based hydrogels for therapeutic applications

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: May 23, 2024

Conventional therapeutic models based on the premise of a universal solution are facing decrease in efficiency, emphasized by large number patients who show resistance or do not respond positively to classic treatments. This perspective highlights urgency for more precise approaches personalized treatments that adaptable specific complexities and unique challenges faced each patient. Hydrogels biocompatible biodegradable systems well-controlled targeted administration agents, being formed 3D reticulated networks water-soluble polymeric biomaterials, natural, synthetic, hybrid origin, with intrinsic extrinsic properties. Due easily adjustable porous structure, hydrogels allow encapsulation macromolecular drugs, proteins, small molecules, cells, hormones, growth factors gel matrix their subsequent controlled release. The biomaterials used, crosslinking methods, design, functionalization strategies obtaining improved properties presented. different possibilities application described transdermally, as dressing materials, oral, ocular, spray-able, injectable, up intracellular level. chapter extensively investigates advances advantages enable effective, noninvasive, provide greater patient comfort wide range applications.

Language: Английский

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Temperature Induced Gelation and Antimicrobial Properties of Pluronic F127 Based Systems

Polymers, Journal Year: 2023, Volume and Issue: 15(2), P. 355 - 355

Published: Jan. 10, 2023

Different formulations containing Pluronic F127 and polysaccharides (chitosan, sodium alginate, gellan gum, κ-carrageenan) were investigated as potential injectable gels that behave free-flowing liquid with reduced viscosity at low temperatures displayed solid-like properties 37 °C. In addition, ZnO nanoparticles, lysozyme, or curcumin added for testing the antimicrobial of thermal-sensitive gels. Rheological investigations evidenced small changes in transition temperature kinetics gelation °C presence polysaccharides. However, gel formation is very delayed curcumin. The are modest even by adding chitosan, nanoparticles. A remarkable enhancement activity was observed Chitosan addition to Pluronic/curcumin systems improves their viscoelasticity, activity, stability time. balance between viscoelastic characteristics needs be considered formulation suitable biomedical pharmaceutical applications.

Language: Английский

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Diversity of Bioinspired Hydrogels: From Structure to Applications

Gels, Journal Year: 2023, Volume and Issue: 9(5), P. 376 - 376

Published: May 2, 2023

Hydrogels are three-dimensional networks with a variety of structures and functions that have remarkable ability to absorb huge amounts water or biological fluids. They can incorporate active compounds release them in controlled manner. also be designed sensitive external stimuli: temperature, pH, ionic strength, electrical magnetic stimuli, specific molecules, etc. Alternative methods for the development various hydrogels been outlined literature over time. Some toxic therefore avoided when obtaining biomaterials, pharmaceuticals, therapeutic products. Nature is permanent source inspiration new functionalities more competitive materials. Natural present series physico-chemical characteristics suitable such as biocompatibility, antimicrobial properties, biodegradability, nontoxicity. Thus, they generate microenvironments comparable intracellular extracellular matrices human body. This paper discusses main advantages presence biomolecules (polysaccharides, proteins, polypeptides) hydrogels. Structural aspects induced by natural their properties emphasized. The most applications will highlighted, including drug delivery, self-healing materials regenerative medicine, cell culture, wound dressings, 3D bioprinting, foods,

Language: Английский

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