Piezocatalytic 2D WS₂ Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(18)

Published: Feb. 13, 2023

Piezoelectric nanomaterials that can generate reactive oxygen species (ROS) by piezoelectric polarization under an external mechanical force have emerged as effective platform for cancer therapy. In this study, 2D WS2 nanosheets are functionalized with mitochondria-targeting triphenylphosphonium (TPP) ultrasound (US)-triggered, mitochondria-targeted piezodynamic addition, a glycolysis inhibitor (FX11) inhibit cellular energy metabolism is loaded into TPP- and poly(ethylene glycol) (PEG)-conjugated nanosheet (TPEG-WS2 ) to potentiate its therapeutic efficacy. Upon US irradiation, the sono-excited electrons holes generated in efficiently separated polarization, which subsequently promotes production of ROS. FX11-loaded TPEG-WS2 (FX11@TPEG-WS2 selectively accumulates mitochondria human breast cells. FX11@TPEG-WS2 effectively inhibits adenosine triphosphate . Thus, exhibits outstanding anticancer effects irradiation. An vivo study using tumor-xenograft mice demonstrates accumulated tumors. Its tumor accumulation visualized computed tomography Notably, irradiation remarkably suppresses growth without systemic toxicity. This combination therapy metabolism-targeted chemotherapy novel strategy selective treatment

Language: Английский

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Bimetallic Organic Frameworks of High Piezovoltage for Sono‐Piezo Dynamic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(41)

Published: July 11, 2023

Piezoelectric materials produce charges to directly act on cancer medium or promote the generation of reactive oxygen species (ROS) for novel tumor therapy triggered by sonography. Currently, piezoelectric sonosensitizers are mainly used catalyze ROS band-tilting effect sonodynamic therapy. However, it remains a challenge high piezovoltages overcome bandgap barrier direct charge generation. Herein, Mn-Ti bimetallic organic framework tetragonal nanosheets (MT-MOF TNS) designed sono-piezo (SP)-dynamic (SPDT) with remarkable antitumor efficacy in vitro and vivo. The MT-MOF TNS comprise non-centrosymmetric secondary building units Mn-Ti-oxo cyclic octamers heterogeneous components piezoelectricity. promotes strong sonocavitation induce SP voltage (2.9 V) situ, excite charges, which is validated SP-excited luminescence spectrometry. depolarize mitochondrial plasma membrane potentials cause overproduction serious cell damage. Importantly, can be decorated targeting molecules chemotherapeutics more severe regression combining SPDT chemodynamic chemotherapy. This report develops fascinating nano-semiconductor provides an efficient strategy treatment.

Language: Английский

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A multifunctional bioresponsive and fluorescent active nanogel composite for breast cancer therapy and bioimaging

Advanced Composites and Hybrid Materials, Journal Year: 2023, Volume and Issue: 6(1)

Published: Jan. 31, 2023

Abstract Bio-responsive nanocomposites with facile fabrication and rational design are of great importance in the diagnosis treatment cancer. Herein, combination bioimaging due to presence QD controlled drug delivery via nanogel was employed for cancer treatment. To this aim, we fabricated a traceable bioresponsive fluorescent active composite by integrating creatinine-functionalized carbon dots (QD) into lecithin-inulin nanogel. Subsequently, PEGylation integration herceptin on were carried out improve biofate its ability target HER2-positive breast The assessment cellular uptake demonstrated that effectively internalized SK-BR-3 cells production reactive oxygen species significantly boosted. Moreover, led high expression P53 Bax genes along low Bcl-2 gene (as promotors apoptosis signaling pathway). enhanced. It inhibiting proliferation as well reduction viability (HER-2 positive) compared MDA-MB-231 (triple-negative). intraperitoneal injection developed formulation MCF-7 cell-bearing BALB/c mice supported observation tumor growth inhibition. Overall, herceptin-adorned PEGylated can be promising theranostic candidate targeting HER-2-positive Graphical

Language: Английский

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The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(4), P. 1140 - 1184

Published: Jan. 1, 2023

Malignant tumors are one of the main diseases leading to death, and vigorous development nanotechnology has opened up new frontiers for antitumor therapy. Currently, researchers focused on solving biomedical challenges associated with traditional anti-tumor medical methods, promoting research nano-drug carriers nano-drugs, which brings great hope improving curative effect reducing toxic side effects. Among systems being investigated, piezoelectric nano biomaterials, including ferroelectrics, pyroelectric materials, have recently received extensive attention applications. By coupling force, light, magnetism or heat electricity, polarized charges generated in these materials microscopically, forming a piezo-potential establishing built-in electric field. Polarized can directly act tumor micro-environment also assist separation inhibit recombination based theory optoelectronic theory. Based this, convert various forms primary energy (such as light energy, mechanical thermal magnetic energy) from surrounding environment into secondary electrical chemical energy). Herein, we review basic principles ferroelectric nanomedicine. Then, summarize types reported date their wide applications treatment, imaging, device construction probe detection treatment fields. discuss relevant characteristics post-processing strategies biomaterials obtain maximum response. Finally, present key future prospects ferroelectric, nanomaterial-based nanoagents efficient harvesting conversion desirable therapeutic outcomes.

Language: Английский

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The operation active sites of O₂ reduction to H₂O₂ over ZnO

Energy & Environmental Science, Journal Year: 2023, Volume and Issue: 16(8), P. 3526 - 3533

Published: Jan. 1, 2023

ZnO@ZnO 2 shows ∼100% 2e − ORR selectivity in neutral media and a rate of 5.47 mol g cat −1 h an FE 95.5% bulk H O production. The situ growth ZnO on restructures the operation active sites to facilitate superior activity.

Language: Английский

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Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2047 - 2065

Published: Jan. 2, 2024

The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration different tissue types. However, it has never been explored boosting chondrogenesis. Furthermore, parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in nanocomposite hydrogel containing barium titanate nanoparticles and graphene oxide nanoflakes stimulated waves precisely controlled (1 MHz 250 mW/cm2, 5 min once every 2 days 10 days) dramatically boost chondrogenic cell commitment vitro. Moreover, fibrotic catabolic factors strongly down-modulated: proteomic analyses reveal such influences biological processes involved cytoskeleton extracellular matrix organization, collagen fibril metabolic processes. optimal regimen also considerable anti-inflammatory effect keeps its ability to chondrogenesis vitro, even an inflammatory milieu. An analytical model predict voltage generated by invested proposed, together computational tool takes into consideration nanoparticle clustering within vacuoles predicts electric field streamline distribution cytoplasm. proposed shows good injectability adhesion cartilage ex vivo, well excellent biocompatibility according ISO 10993. Future perspectives will involve preclinical testing paradigm regeneration.

Language: Английский

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Dynamic defects boost in-situ H ₂ O ₂ piezocatalysis for water cleanup

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(9)

Published: Feb. 20, 2024

Creating efficient catalysts for simultaneous H 2 O generation and pollutant degradation is vital. Piezocatalytic synthesis offers a promising alternative to traditional methods but faces challenges like sacrificial reagents, harsh conditions, low activity. In this study, we introduce cobalt-loaded ZnO (CZO) piezocatalyst that efficiently generates from under ultrasonic (US) treatment in ambient aqueous conditions. The catalyst demonstrates exceptional performance with ~50.9% TOC removal of phenol situ 1.3 mM , significantly outperforming pure ZnO. Notably, the CZO maintains its capability even after multiple cycles, showing continuous improvement (from 1.8 mM). This attributed piezoelectric electrons promoting dynamic defects US which turn promotes adsorption activation oxygen, thereby facilitating production, as confirmed by EPR spectrometry, XPS analysis, DFT calculations. Moreover, piezocatalysts maintain outstanding production long periods inactivity, deactivated due metal ion dissolution could be rejuvenated pH adjustment, offering sustainable solution wastewater purification.

Language: Английский

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Oxygen‐Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH‐Responsive Multicompartmental Carriers with Sequential Drug Release Capability

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 14, 2024

Abstract Piezocatalytic cancer therapy, in which piezoelectric nanomaterials generate reactive oxygen species (ROS) via piezocatalytic redox reactions under mechanical stress, has emerged as an effective strategy for treatment. However, the inherent hypoxia tumor microenvironments enormously restricts its efficacy. To address this issue, acid‐degradable Janus‐type multicompartmental carriers able to separately encapsulate gold nanoparticle‐coated poly(ethylene glycol)‐modified zinc oxide nanorods (Au@P‐ZnO NRs) and O 2 ‐generating catalase (CAT) are fabricated study using stop‐flow lithography (SFL). The CAT Au@P‐ZnO NRs sequentially released by modulating composition ratios of acid‐cleavable monomers precursor solution during SFL. sequential release Janus significantly increased intracellular ROS levels conditions upon ultrasound irradiation owing supplied CAT. An vivo showed that a single intratumoral injection particles encapsulating efficiently alleviated substantially suppressed growth. This demonstrates pH‐responsive, ‐generating, have high potential therapy hypoxic tumors offers insights into pH‐responsive efficient hypoxia‐relieving cascade oxygenation generation.

Language: Английский

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