Double Cross‐Linked Biomimetic Hyaluronic Acid‐Based Hydrogels with Thermo‐Stimulated Self‐Contraction and Tissue Adhesiveness for Accelerating Post‐Wound Closure and Wound Healing

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(26)

Published: March 25, 2023

Abstract When skin trauma occurs, rapid achievement of the post‐wound closure is required to prevent microbial invasion, inhibit scar formation and promote wound healing. To develop a dressing for accelerating post‐wound‐closure healing, thermo‐responsive tissue‐adhesive hydrogel with interpenetrating polymer networks (IPN) fabricated based on N ‐dimethylbisacrylamide (NIPAM) glutaraldehyde (GTA) cross‐linked hyaluronic acid (HA). Results not only confirm thermo‐stimulated self‐contraction tissue adhesiveness HA‐based IPN (PNI‐HA), which effectively aids via mechanical stretch, but also verify hemocompatibility cytocompatibility PNI‐HA that tend accelerate In vivo, mouse model total defect demonstrates acting as sealant significantly achieves sutureless at early stage then promotes healing by reducing inflammatory cells infiltration, promoting angiogenesis well collagen deposition. These results indicate developed offers candidate serve

Language: Английский

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A Semi‐Interpenetrating Poly(Ionic Liquid) Network‐Driven Low Hysteresis and Transparent Hydrogel as a Self‐Powered Multifunctional Sensor

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: May 6, 2024

Abstract Conductive hydrogels are gaining significant attention as promising candidates for the fabrication materials flexible electronics. Nevertheless, improving tensile properties, hysteresis, durability, adhesion, and electrochemical properties of these remains challenging. This work reports development a novel semi‐interpenetrating network poly(ionic liquid) hydrogel named PATV, via in situ polymerization acrylamide, N ‐[Tris(hydroxymethyl)methyl] 1‐vinyl‐3‐butylimidazolium tetrafluoroborate. The density functional theory calculations reveal that acts physical cross–linking points to construct hydrogen‐bond networks. Furthermore, networks dissipate energy efficiently quickly, thus stress concentration hysteresis avoided. prepared has low (9%), high (900%), fast response (180 ms), sensitivity (gauge factor = 10.4, pressure 0.14 kPa −1 ), wide sensing range (tensile range: 1–600%, compression 0.1–20 kPa). A multifunctional sensor designed based on enables real‐time, rapid, stable response‐ability detection human movement, facial expression recognition, pronunciation, pulse, handwriting, Morse code encryption. assembled triboelectric nanogenerator displays an excellent harvesting capability, highlighting its potential application self‐powered wearable electronic devices.

Language: Английский

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Novel Natural Polymer‐Based Hydrogel Patches with Janus Asymmetric‐Adhesion for Emergency Hemostasis and Wound Healing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: April 27, 2024

Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.

Language: Английский

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A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122064 - 122064

Published: March 15, 2024

Language: Английский

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Bioinspired wet adhesive carboxymethyl cellulose-based hydrogel with rapid shape adaptability and antioxidant activity for diabetic wound repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122014 - 122014

Published: March 4, 2024

Language: Английский

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Lab on the Microneedles: A Wearable Metal–organic Frameworks-Based Sensor for Visual Monitoring of Stress Hormone

ACS Nano, Journal Year: 2024, Volume and Issue: 18(22), P. 14207 - 14217

Published: May 20, 2024

Abnormal secretion and dysrhythmias of cortisol (CORT) are associated with various diseases such as sleep disorders, depression, chronic fatigue. Wearable devices a cutting-edge technology for point-of-care detection dynamic monitoring CORT inspiring convenience. Herein, we developed minimally invasive skin-worn device the advanced integration both interstitial fluid (ISF) sampling target molecule sensing simultaneous via microneedle-based sensor high sensitivity, excellent efficiency, outstanding reproducibility. In microneedle patch, swellable hydrogel was employed adsorption matrix ISF extraction. Meanwhile, europium metal–organic frameworks (Eu-MOF) wrapped in played vital role recognition quantitative analysis. The wearable label-free Eu-MOF-loaded patch exhibited sensitivity limit reaching 10–9 M selectivity. Molecular dynamics simulation–driven mechanism exploration revealed that strong interface interaction promoted fluorescence quenching Eu-MOF. Moreover, vitro vivo investigation confirmed feasibility reliability method, biocompatibility validated. Overall, sensitive approach based on Eu-MOF (MN) established visible exciting clinical-translational ability.

Language: Английский

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Janus Polyurethane Adhesive Patch with Antibacterial Properties for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 15970 - 15980

Published: March 19, 2024

Despite the rapid development of tissue adhesives, flaws including allergies, poor stability, and indiscriminate double-sided adhesive properties limit their application in medical field. In this work, Janus polyurethane patches were spontaneously prepared by adjusting difference functional group distribution between top bottom sides patch during emulsion drying. Consequently, adhesion was exhibited on surface, while surface can easily adhere to metals, polymers, glasses, tissues. The strength pork skin two surfaces is more than 5 times. quaternary ammonium salt hydrophilic components enable removal absorption water from achieve wet adhesion. Animal experiments have demonstrated that multifunctional promote wound closure healing infected wounds. This facile effective strategy construct provides a promising method for tissue-adhesives.

Language: Английский

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Antibacterial and anti-inflammatory synergistic effects of double-layer hydrogel promoting bacterial wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152513 - 152513

Published: May 23, 2024

Language: Английский

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A Photo‐induced Cross‐Linking Enhanced A and B Combined Multi‐Functional Spray Hydrogel Instantly Protects and Promotes of Irregular Dynamic Wound Healing

Small, Journal Year: 2024, Volume and Issue: 20(23)

Published: March 10, 2024

Abstract Wounds in harsh environments can face long‐term inflammation and persistent infection, which slow healing. Wound spray is a product that be rapidly applied to large irregularly dynamic wounds, quickly form protective film situ inhibit external environmental infection. In this study, biodegradable A B combined multi‐functional hydrogel developed with methacrylate‐modified chitosan (CSMA 1st ) ferulic acid (FA) as type raw materials oxidized Bletilla striata polysaccharide (OBSP) materials. The precursor CSMA ‐FA/OBSP (CSOB‐FA formed by the self‐cross‐linking of Schiff base bonds, CSMA‐FA/OBSP (CSOB‐FA) after UV–vis light, so fits wound. Rapid spraying curing provide sufficient flexibility rapidity for wounds has good injectability, adhesive, mechanical strength. rats miniature pigs, shrink promote healing infected enrichment fibrocyte populations. Therefore, multifunctional protect irregular prevent wound infection secondary injury, used safe effective treatment, prospect development.

Language: Английский

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Hydrogel Wound Dressings Accelerating Healing Process of Wounds in Movable Parts

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6610 - 6610

Published: June 15, 2024

Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives

Language: Английский

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