An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Oct. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Language: Английский

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Fully Polymeric Conductive Hydrogels with Low Hysteresis and High Toughness as Multi‐Responsive and Self‐Powered Wearable Sensors

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(32)

Published: April 22, 2024

Abstract High mechanical strength, excellent toughness, low hysteresis, and robust resilience are of great importance for stretchable conductive hydrogels (CHs) to heighten their reliabilities self‐powered sensing applications. However, it still remains challenging simultaneously obtain the mutually exclusive performances. Herein, an intrinsically adhesive hydrogel is fabricated by one‐step radical polymerization acrylamide (AAm), three hydroxy groups together clustered‐N‐[tris(hydroxymethyl)methyl]acrylamide (THMA), cationic 1‐Butyl‐3‐Vinylimidazolium Bromide (ILs) dissolved in core‐shell structurally dispersed PEDOT:PSS (PP) solution. Owing abundant clustered hydrogen bonds, electrostatic interactions between PILs chains anionic PSS shells, polymer chain entanglements, CHs feature superior properties with a high tensile strength (0.25 MPa), fracture strain (1015%), toughness (1.22 MJ m ‐3 ), energy 36.5 kJ ‐2 extremely hysteresis (5%), display fatigue resistance. As result, indicate gauge factor up 10.46, broad range (1‐900%) pressure (0.05‐100 kPa), fast responsive rate, thus qualifying monitoring reliably accurately large tiny human movements daily life. Moreover, hydrogel‐assembled triboelectric nanogenerators (TENGs) exhibit stable electrical output performances, which greatly promising flexible wearable electronics.

Language: Английский

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Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150756 - 150756

Published: March 26, 2024

Language: Английский

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Bioinspired wet adhesive carboxymethyl cellulose-based hydrogel with rapid shape adaptability and antioxidant activity for diabetic wound repair

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122014 - 122014

Published: March 4, 2024

Language: Английский

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Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: April 3, 2024

Abstract Burns can cause severe damage to the skin due bacterial infection and inflammation. Although conductive hydrogels as electroactive burn‐wound dressings achieve remarkable effects on accelerating wound healing, issues such imbalance between their high conductivity mechanical properties, easy dehydration, low transparency must be addressed. Herein, a double‐network eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide‐polymerization crosslink) thiolated hyaluronic acid (disulfide‐bonding crosslink). The introduction of PDESs provides with (up 0.25 S·m −1 ) strength (tensile strain 59–77%) simulating those natural human skin, well satisfactory tissue adhesiveness, self‐healing ability, antibacterial properties. When combined exogenous electrical stimulation, exhibits ability reduce inflammation, stimulate cell proliferation migration, promote collagen deposition angiogenesis, facilitate remodeling. This shows great potential dressing for healing major burn wounds.

Language: Английский

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Janus Polyurethane Adhesive Patch with Antibacterial Properties for Wound Healing

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(13), P. 15970 - 15980

Published: March 19, 2024

Despite the rapid development of tissue adhesives, flaws including allergies, poor stability, and indiscriminate double-sided adhesive properties limit their application in medical field. In this work, Janus polyurethane patches were spontaneously prepared by adjusting difference functional group distribution between top bottom sides patch during emulsion drying. Consequently, adhesion was exhibited on surface, while surface can easily adhere to metals, polymers, glasses, tissues. The strength pork skin two surfaces is more than 5 times. quaternary ammonium salt hydrophilic components enable removal absorption water from achieve wet adhesion. Animal experiments have demonstrated that multifunctional promote wound closure healing infected wounds. This facile effective strategy construct provides a promising method for tissue-adhesives.

Language: Английский

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Polysaccharide- and protein-based hydrogel dressings that enhance wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135482 - 135482

Published: Sept. 1, 2024

Language: Английский

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Hydrogel Wound Dressings Accelerating Healing Process of Wounds in Movable Parts

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6610 - 6610

Published: June 15, 2024

Skin is the largest organ in human body and requires proper dressing to facilitate healing after an injury. Wounds on movable parts, such as elbow, knee, wrist, neck, usually undergo delayed inefficient due frequent movements. To better accommodate wounds, a variety of functional hydrogels have been successfully developed used flexible wound dressings. On one hand, mechanical properties, adhesion, stretchability, self-healing, make these suitable for mobile wounds promote process; other bioactivities, antibacterial antioxidant performance, could further accelerate process. In this review, we focus recent advances hydrogel-based dressings propose challenges perspectives

Language: Английский

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Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Language: Английский

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Nanocomposite Hydrogel for Real‐Time Wound Status Monitoring and Comprehensive Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Abstract Current skin sensors or wound dressings fall short in addressing the complexities and challenges encountered real‐world scenarios, lacking adequate capability to facilitate repair. The advancement of methodologies enabling early diagnosis, real‐time monitoring, active regulation drug delivery for timely comprehensive treatment holds paramount significance complex chronic wounds. In this study, a nanocomposite hydrogel is devised monitoring condition treatment. Tannins siRNA containing matrix metalloproteinase‐9 gene interference are self‐assembled construct degradable nanogel modified with bovine serum albumin. pH indicator encapsulated within dual‐crosslinking synthesized norbornene dianhydride‐modified paramylon. exhibited excellent shape adaptability due borate bonding, click polymerization reaction led rapid situ curing hydrogel. system not only monitors pH, temperature, exudate alterations, peristalsis during healing but also exhibits hemostatic, antimicrobial, anti‐inflammatory, antioxidant properties, modulates macrophage polarization, facilitates vascular tissue regeneration. This therapeutic approach, which integrates pathological parameters treatment, anticipated address clinical issues associated diabetic wounds infected wounds, offering broad prospects application.

Language: Английский

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