CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Nature, Journal Year: 2019, Volume and Issue: 569(7755), P. 270 - 274

Published: May 1, 2019

Language: Английский

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Tumor microenvironment complexity and therapeutic implications at a glance

Cell Communication and Signaling, Journal Year: 2020, Volume and Issue: 18(1)

Published: April 7, 2020

Abstract The dynamic interactions of cancer cells with their microenvironment consisting stromal (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity cell, clonal evolution increase multidrug resistance ending in cell progression metastasis. reciprocal cell-cell/ECM interaction tumor hijacking non-malignant force lose function acquire new phenotypes that promote development invasion cells. Understanding underlying cellular molecular mechanisms governing these can be used as a novel strategy indirectly disrupt interplay contribute efficient safe therapeutic strategies fight cancer. Furthermore, tumor-derived circulating materials also diagnostic tools precisely predict monitor outcome therapy. This review evaluates such potentials various advanced models, focus on 3D systems well lab-on-chip devices.

Language: Английский

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Macrophages and Metabolism in the Tumor Microenvironment

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(1), P. 36 - 50

Published: July 1, 2019

Language: Английский

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Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

Frontiers in Immunology, Journal Year: 2018, Volume and Issue: 8

Published: Jan. 9, 2018

The immune system is the most important protective physiological of organism. It has many connections with other systems and is, in fact, often considered as part larger neuro-endocrine-immune axis. Most experimental data on changes aging show a decline parameters when compared to young healthy subjects. bulk these termed immunosenescence. Immunosenescence been for some time detrimental because it leads subclinical accumulation proinflammatory factors inflamm-aging. Together, immunosenescence inflamm-aging are suggested stand at origin diseases elderly, such infections, cancer, autoimmune disorders, chronic inflammatory diseases. However, an increasing number immune-gerontologists have challenged this negative interpretation respect its significance aging-related alterations system. If one considers from evolutionary perspective, they can be viewed preferably adaptive or remodeling rather than solely detrimental. Whereas conceivable that global may lead various diseases, also obvious needed extended survival/longevity. Recent cumulative suggest that, without existence immunosenescence/inflamm-aging duo (representing two sides same phenomenon), human longevity would greatly shortened. This review summarizes recent dynamic reassessment aging. Accordingly, attempts intervene by targeting rejuvenation, more suitable aim maintain general homeostasis function appropriately improving immune-inflammatory-functions.

Language: Английский

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Mitochondrial metabolism and cancer

Cell Research, Journal Year: 2017, Volume and Issue: 28(3), P. 265 - 280

Published: Dec. 8, 2017

Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view instrumental development of powerful imaging tools that are still used clinics, it is now clear mitochondria play key role oncogenesis. Besides exerting central bioenergetic functions, provide indeed building blocks tumor anabolism, control redox calcium homeostasis, participate transcriptional regulation, govern cell death. Thus, constitute promising targets novel anticancer agents. However, tumors arise, progress, respond to therapy context an intimate crosstalk with host immune system, many immunological functions rely on intact mitochondrial metabolism. Here, we review cell-intrinsic cell-extrinsic mechanisms through which influence all steps oncogenesis, focus therapeutic potential targeting metabolism therapy.

Language: Английский

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Targeting Metabolism for Cancer Therapy

Cell chemical biology, Journal Year: 2017, Volume and Issue: 24(9), P. 1161 - 1180

Published: Sept. 1, 2017

Language: Английский

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Targeting Tumor-Associated Macrophages in Cancer

Trends in Immunology, Journal Year: 2019, Volume and Issue: 40(4), P. 310 - 327

Published: March 17, 2019

Language: Английский

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Harnessing innate immunity in cancer therapy

Nature, Journal Year: 2019, Volume and Issue: 574(7776), P. 45 - 56

Published: Oct. 2, 2019

Language: Английский

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Unraveling the Complex Interplay Between T Cell Metabolism and Function

Annual Review of Immunology, Journal Year: 2018, Volume and Issue: 36(1), P. 461 - 488

Published: April 20, 2018

Metabolism drives function, on both an organismal and a cellular level. In T cell biology, metabolic remodeling is intrinsically linked to development, activation, differentiation, survival. After naive cells are activated, increased demands for currency in the form of ATP, as well biomass growth, proliferation, production effector molecules, met by rewiring metabolism. Consequently, pharmacological strategies being developed perturb or enhance selective processes that skewed immune-related pathologies. Here we review most recent advances describing changes occur during lifecycle. We discuss how metabolism can have profound effects health disease where it might be promising target treat variety

Language: Английский

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The clinical role of the TME in solid cancer

British Journal of Cancer, Journal Year: 2018, Volume and Issue: 120(1), P. 45 - 53

Published: Nov. 9, 2018

The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial stromal fibroblasts, variety immune that control growth invasion. It is well established anti-tumour immunity critical hurdle must be overcome for tumours to initiate, grow spread can modulated using current immunotherapies achieve meaningful clinical responses. Pioneering studies in melanoma, ovarian colorectal cancer have demonstrated certain features microenvironment (TME)—in particular, degree infiltration by cytotoxic T cells—can predict patient's outcome. More recently, renal cell highlighted importance assessing phenotype infiltrating early relapse. Furthermore, intricate interactions with non-immune cellular players fibroblasts modulate impact TME. Here, we review components TME solid how they shape contexture, summarise numerous evaluating its significance prognostic theranostic perspective.

Language: Английский

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