Four Key Steps Control Glycolytic Flux in Mammalian Cells DOI Creative Commons

Lukas B. Tanner,

Alexander G. Goglia, Monica Wei

et al.

Cell Systems, Journal Year: 2018, Volume and Issue: 7(1), P. 49 - 62.e8

Published: June 28, 2018

Language: Английский

Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus DOI
Marc Foretz, Bruno Guigas, Benoı̂t Viollet

et al.

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(10), P. 569 - 589

Published: Aug. 22, 2019

Language: Английский

Citations

524
TH2 cell development and function DOI
Jennifer A. Walker, Andrew N. J. McKenzie

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 18(2), P. 121 - 133

Published: Oct. 30, 2017

Language: Английский

Citations

501
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability DOI Creative Commons

Mark R. Sullivan,

Laura V. Danai,

Caroline A. Lewis

et al.

eLife, Journal Year: 2019, Volume and Issue: 8

Published: April 16, 2019

Cancer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availability. Therefore, knowledge of levels essential to understand tumor metabolism. To measure the extracellular available tumors, we utilized quantitative metabolomics methods absolute concentrations >118 metabolites in plasma and interstitial fluid, fluid that perfuses tumors. Comparison revealed nutrients tumors differ from those present circulation. Further, comparing between autochthonous transplant models murine pancreatic lung adenocarcinoma, found type, anatomical location animal diet affect local These data provide a comprehensive characterization microenvironment widely used cancer identify factors influence metabolite

Language: Английский

Citations

470
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity DOI Creative Commons

Ken Yoshii,

Koji Hosomi,

Kento Sawane

et al.

Frontiers in Nutrition, Journal Year: 2019, Volume and Issue: 6

Published: April 17, 2019

Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases. Since B vitamins synthesized by plants, yeasts, bacteria, but not mammals, mammals must acquire from dietary or microbial sources, such as the intestinal microbiota. Similarly, some bacteria unable synthesize them diet other for their growth survival. This suggests composition function microbiota may affect usage and, extension, Here, we review immunological functions metabolism with respect control

Language: Английский

Citations

463
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors DOI Creative Commons
Shihao Xu,

Omkar Chaudhary,

Patricia Rodríguez-Morales

et al.

Immunity, Journal Year: 2021, Volume and Issue: 54(7), P. 1561 - 1577.e7

Published: June 7, 2021

Language: Английский

Citations

462
The impact of cellular metabolism on chromatin dynamics and epigenetics DOI
Michael A. Reid, Ziwei Dai, Jason W. Locasale

et al.

Nature Cell Biology, Journal Year: 2017, Volume and Issue: 19(11), P. 1298 - 1306

Published: Oct. 23, 2017

Language: Английский

Citations

440
The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity DOI Creative Commons
Jan P. Böttcher, Caetano Reis e Sousa

Trends in cancer, Journal Year: 2018, Volume and Issue: 4(11), P. 784 - 792

Published: Sept. 29, 2018

Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection immunogenic cancers and success T cell-based immunotherapies. The unique role cDC1 reflects ability to initiate de novo cell responses after migrating tumor-draining lymph nodes, as well attract cells, secrete cytokines, present tumor antigens within microenvironment, enhancing local cytotoxic function. Strategies aimed at increasing abundance tumors their functionality provide attractive new avenues boost anti-tumor immunity overcome resistance

Language: Английский

Citations

438
Amino Assets: How Amino Acids Support Immunity DOI Creative Commons
Beth Kelly, Erika L. Pearce

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(2), P. 154 - 175

Published: July 9, 2020

Language: Английский

Citations

413
Metabolic landscape of the tumor microenvironment at single cell resolution DOI Creative Commons
Zhengtao Xiao, Ziwei Dai, Jason W. Locasale

et al.

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: Aug. 21, 2019

The tumor milieu consists of numerous cell types each existing in a different environment. However, characterization metabolic heterogeneity at single-cell resolution is not established. Here, we develop computational pipeline to study programs single cells. In two representative human cancers, melanoma and head neck, apply this algorithm define the intratumor landscape. We report an overall discordance between analyses cells those bulk tumors with higher activity malignant than previously appreciated. Variation mitochondrial found be major contributor heterogeneity. Surprisingly, expression both glycolytic strongly correlates hypoxia all types. Immune stromal could also distinguished by their features. Taken together analysis establishes framework for characterizing metabolism using data defines principles microenvironment.

Language: Английский

Citations

398
Helper T cell differentiation DOI Open Access
Jordy Saravia, Nicole M. Chapman, Hongbo Chi

et al.

Cellular and Molecular Immunology, Journal Year: 2019, Volume and Issue: 16(7), P. 634 - 643

Published: March 12, 2019

Citations

395