Cancer neuroscience: State of the field, emerging directions

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1689 - 1707

Published: April 1, 2023

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, promoting plasticity throughout life, the plays parallel roles in regulation of cancers. Foundational discoveries have elucidated direct paracrine electrochemical communication between neurons cancer cells, as well indirect interactions through neural effects on immune stromal cells tumor microenvironment a wide range malignancies. Nervous system-cancer can regulate oncogenesis, growth, invasion metastatic spread, treatment resistance, stimulation tumor-promoting inflammation, impairment anti-cancer immunity. Progress neuroscience may create an important new pillar therapy.

Language: Английский

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ME/CFS and Long COVID share similar symptoms and biological abnormalities: road map to the literature

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

Some patients remain unwell for months after "recovering" from acute COVID-19. They develop persistent fatigue, cognitive problems, headaches, disrupted sleep, myalgias and arthralgias, post-exertional malaise, orthostatic intolerance other symptoms that greatly interfere with their ability to function can leave some people housebound disabled. The illness (Long COVID) is similar myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) as well persisting illnesses follow a wide variety of infectious agents following major traumatic injury. Together, these are projected cost the U.S. trillions dollars. In this review, we first compare ME/CFS Long COVID, noting considerable similarities few differences. We then in extensive detail underlying pathophysiology two conditions, focusing on abnormalities central autonomic nervous system, lungs, heart, vasculature, immune gut microbiome, energy metabolism redox balance. This comparison highlights how strong evidence each abnormality, illness, helps set priorities future investigation. review provides current road map literature biology both illnesses.

Language: Английский

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Transforming the understanding of brain immunity

Science, Journal Year: 2023, Volume and Issue: 380(6640)

Published: April 6, 2023

Contemporary studies have completely changed the view of brain immunity from envisioning as isolated and inaccessible to peripheral immune cells an organ in close physical functional communication with system for its maintenance, function, repair. Circulating reside special niches brain's borders, choroid plexus, meninges, perivascular spaces, which they patrol sense a remote manner. These niches, together meningeal lymphatic skull microchannels, provide multiple routes interaction between system, addition blood vasculature. In this Review, we describe current ideas about their implications aging, diseases, immune-based therapeutic approaches.

Language: Английский

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The enteric nervous system relays psychological stress to intestinal inflammation

Cell, Journal Year: 2023, Volume and Issue: 186(13), P. 2823 - 2838.e20

Published: May 25, 2023

Language: Английский

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The neuroscience of cancer

Nature, Journal Year: 2023, Volume and Issue: 618(7965), P. 467 - 479

Published: June 14, 2023

Language: Английский

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Inflammatory memory and tissue adaptation in sickness and in health

Nature, Journal Year: 2022, Volume and Issue: 607(7918), P. 249 - 255

Published: July 13, 2022

Language: Английский

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Brain borders at the central stage of neuroimmunology

Nature, Journal Year: 2022, Volume and Issue: 612(7940), P. 417 - 429

Published: Dec. 14, 2022

Language: Английский

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A body–brain circuit that regulates body inflammatory responses

Nature, Journal Year: 2024, Volume and Issue: 630(8017), P. 695 - 703

Published: May 1, 2024

Language: Английский

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Immune sensing of food allergens promotes avoidance behaviour

Nature, Journal Year: 2023, Volume and Issue: 620(7974), P. 643 - 650

Published: July 12, 2023

Abstract In addition to its canonical function of protection from pathogens, the immune system can also alter behaviour 1,2 . The scope and mechanisms behavioural modifications by are not yet well understood. Here, using mouse models food allergy, we show that allergic sensitization drives antigen-specific avoidance behaviour. Allergen ingestion activates brain areas involved in response aversive stimuli, including nucleus tractus solitarius, parabrachial central amygdala. requires immunoglobulin E (IgE) antibodies mast cells but precedes development gut inflammation. ability allergen-specific IgE promote cysteinyl leukotrienes growth differentiation factor 15. Finally, a comparison C57BL/6 BALB/c strains revealed strong effect genetic background on These findings thus point probably evolved niche selection avoid unfavourable environments.

Language: Английский

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Central regulation of stress-evoked peripheral immune responses

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(10), P. 591 - 604

Published: Aug. 25, 2023

Language: Английский

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