Nature Reviews Rheumatology, Journal Year: 2023, Volume and Issue: 19(12), P. 790 - 804
Published: Nov. 3, 2023
Language: Английский
Annual Review of Neuroscience, Journal Year: 2023, Volume and Issue: 46(1), P. 211 - 231
Published: March 14, 2023
Emotions are fundamental to our experience and behavior, affecting motivating all aspects of lives. Scientists various disciplines have been fascinated by emotions for centuries, yet even today vigorous debates abound about how define best study their neural underpinnings. Defining from an evolutionary perspective acknowledging important functional roles in supporting survival allows the emotion states diverse species. This approach enables taking advantage modern tools behavioral, systems, circuit neurosciences, allowing precise dissection mechanisms behavior underlying processes model organisms. Here we review findings processing across species try identify points convergence as well next steps pursuit understanding emerge activity.
Language: Английский
Citations
63
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5742 - 5742
Published: March 17, 2023
The tryptophan and kynurenine pathway is well-known to play an important role in nervous, endocrine, immune systems, as well the development of inflammatory diseases. It has been documented that some metabolites are considered have anti-oxidative, anti-inflammatory, and/or neuroprotective properties. Importantly, many these may possess immune-regulatory properties could alleviate inflammation response. abnormal activation might be involved pathophysiological process various immune-related diseases, such bowel disease, cardiovascular osteoporosis, polycystic ovary syndrome. Interestingly, brain memory system intricate immunity via modulation glial function. In further deliberation this concept with engram, roles gut microbiota lead remarkable treatments for prevention therapeutics intractable
Language: Английский
Citations
63
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(8), P. 3194 - 3206
Published: Aug. 1, 2023
Social behaviors, how individuals act cooperatively and competitively with conspecifics, are widely seen across species. Rodents display various social many different behavioral paradigms have been used for investigating their neural circuit bases. behavior is highly vulnerable to brain network dysfunction caused by neurological neuropsychiatric conditions such as autism spectrum disorders (ASDs). Studying mouse models of ASD provides a promising avenue toward elucidating mechanisms abnormal potential therapeutic targets treatment. In this review, we outline recent progress key findings on underlying behavior, particular emphasis rodent studies that monitor manipulate the activity specific circuits using modern systems neuroscience approaches. mediated distributed brain-wide among major cortical (e.g., medial prefrontal cortex (mPFC), anterior cingulate cortex, insular (IC)) subcortical nucleus accumbens, basolateral amygdala (BLA), ventral tegmental area) structures, influenced multiple neuromodulatory oxytocin, dopamine, serotonin). We particularly draw special attention IC unique area mediates multisensory integration, encoding ongoing interaction, decision-making, emotion, empathy. Additionally, synthesis demonstrates dysfunctions in mPFC-BLA circuitry neuromodulation prominent. Pharmacological rescues local or systemic oral) administration drugs provided valuable clues developing new agents ASD. Future efforts technological advances will push forward next frontiers field, elucidation inter-brain dynamics during real virtual interactions, establishment circuit-based therapy affecting functions.
Language: Английский
Citations
50
Science, Journal Year: 2024, Volume and Issue: 385(6708)
Published: Aug. 1, 2024
Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense. However, the matrix of interactions between arrays molecularly defined neuron subsets immunocyte lineages remains unclear. We used a chemogenetic approach to activate eight distinct neuronal subsets, assessing effects by deep immunophenotyping, microbiome profiling, transcriptomics organs. Distinct immune perturbations followed activation: Nitrergic neurons regulated T helper 17 (T
Language: Английский
Citations
25
Cell, Journal Year: 2024, Volume and Issue: 187(9), P. 2079 - 2094
Published: April 1, 2024
Several conceptual pillars form the foundation of modern immunology, including clonal selection theory, antigen receptor diversity, immune memory, and innate control adaptive immunity. However, some immunological phenomena cannot be explained by current framework. Thus, we still do not know how to design vaccines that would provide long-lasting protective immunity against certain pathogens, why autoimmune responses target antigens others, or response infection sometimes does more harm than good. Understanding these mysteries may require question existing assumptions develop test alternative explanations. Immunology is increasingly at a point when, once again, exploring new perspectives becomes necessity.
Language: Английский
Citations
19
Annual Review of Immunology, Journal Year: 2024, Volume and Issue: 42(1), P. 489 - 519
Published: June 28, 2024
Recent advances have contributed to a mechanistic understanding of neuroimmune interactions in the intestine and revealed an essential role this cross talk for gut homeostasis modulation inflammatory infectious intestinal diseases. In review, we describe innervation by intrinsic extrinsic neurons then focus on bidirectional communication between immune cells. First, highlight contribution neuronal subtypes development colitis discuss different epithelial cell types that are regulated via release neuropeptides neurotransmitters. Next, review inflammation visceral hypersensitivity summarize how mediators induce peripheral central sensitization gut-innervating sensory neurons. Finally, outline importance cells microbiota survival function populations at during bacterial helminth infection.
Language: Английский
Citations
17
Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(3), P. 471 - 483
Published: Jan. 30, 2024
Language: Английский
Citations
16
Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)
Published: Jan. 19, 2025
Major depressive disorder is a prevalent mental disorder, yet its pathogenesis remains poorly understood. Accumulating evidence implicates dysregulated immune mechanisms as key contributors to disorders. This review elucidates the complex interplay between peripheral and central components underlying pathology. Peripherally, systemic inflammation, gut dysregulation, dysfunction in organs including gut, liver, spleen adipose tissue influence brain function through neural molecular pathways. Within nervous system, aberrant microglial astrocytes activation, cytokine imbalances, compromised blood-brain barrier integrity propagate neuroinflammation, disrupting neurotransmission, impairing neuroplasticity, promoting neuronal injury. The crosstalk immunity creates vicious cycle exacerbating neuropathology. Unraveling these multifaceted immune-mediated provides insights into major disorder's pathogenic basis potential biomarkers targets. Modulating both responses represent promising multidimensional therapeutic strategy.
Language: Английский
Citations
5
Nature, Journal Year: 2025, Volume and Issue: 638(8050), P. 333 - 342
Published: Feb. 12, 2025
Language: Английский
Citations
3
Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
2