Redox Biology,
Journal Year:
2024,
Volume and Issue:
72, P. 103123 - 103123
Published: March 12, 2024
Redox
signaling,
a
mode
of
signal
transduction
that
involves
the
transfer
electrons
from
nucleophilic
to
electrophilic
molecule,
has
emerged
as
an
essential
regulator
inflammatory
macrophages.
reactions
are
driven
by
reactive
oxygen/nitrogen
species
(ROS
and
RNS)
redox-sensitive
metabolites
such
fumarate
itaconate
which
can
post-translationally
modify
specific
cysteine
residues
in
target
proteins.
In
past
decade
our
understanding
how
ROS,
RNS,
control
macrophage
function
expanded
dramatically.
this
review,
we
discuss
latest
evidence
regulate
is
dysregulated
with
disease.
We
highlight
key
tools
assess
redox
signaling
important
questions
remain.
Cell Metabolism,
Journal Year:
2022,
Volume and Issue:
34(11), P. 1620 - 1653
Published: Nov. 1, 2022
The
analogy
of
mitochondria
as
powerhouses
has
expired.
Mitochondria
are
living,
dynamic,
maternally
inherited,
energy-transforming,
biosynthetic,
and
signaling
organelles
that
actively
transduce
biological
information.
We
argue
the
processor
cell,
together
with
nucleus
other
they
constitute
mitochondrial
information
processing
system
(MIPS).
In
a
three-step
process,
(1)
sense
respond
to
both
endogenous
environmental
inputs
through
morphological
functional
remodeling;
(2)
integrate
network-based
physical
interactions
diffusion
mechanisms;
(3)
produce
output
signals
tune
functions
systemically
regulate
physiology.
This
input-to-output
transformation
allows
metabolic,
biochemical,
neuroendocrine,
local
or
systemic
enhance
organismal
adaptation.
An
explicit
focus
on
signal
transduction
emphasizes
role
communication
in
biology.
framework
also
opens
new
avenues
understand
how
mediate
inter-organ
processes
underlying
human
health.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(30)
Published: Aug. 26, 2023
Nitric
oxide
(NO)
is
a
gaseous
molecule
that
has
central
role
in
signaling
pathways
involved
numerous
physiological
processes
(e.g.,
vasodilation,
neurotransmission,
inflammation,
apoptosis,
and
tumor
growth).
Due
to
its
form,
NO
short
half-life,
physiology
concentration
dependent,
often
restricting
function
target
site.
Providing
from
an
external
source
beneficial
promoting
cellular
functions
treatment
of
different
pathological
conditions.
Hence,
the
multifaceted
pathology
garnered
massive
interest
developing
strategies
deliver
exogenous
for
various
regenerative
biomedical
complexities.
NO-releasing
platforms
or
donors
capable
delivering
controlled
sustained
manner
tissues
organs
have
advanced
past
few
decades.
This
review
article
discusses
detail
generation
via
enzymatic
synthase
as
well
multiple
biological
modulates.
The
methods
incorporating
into
diverse
biomaterials
including
physical,
chemical,
supramolecular
techniques
are
summarized.
Then,
these
highlighted
terms
advancing
medical
problems.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(16), P. 5607 - 5651
Published: Jan. 1, 2023
Since
their
inception,
rhodamine
dyes
have
been
extensively
applied
in
biotechnology
as
fluorescent
markers
or
for
the
detection
of
biomolecules
owing
to
good
optical
physical
properties.
Accordingly,
they
emerged
a
powerful
tool
visualization
living
systems.
In
addition
fluorescence
bioimaging,
molecular
design
derivatives
with
disease
therapeutic
functions
(e.g.,
cancer
and
bacterial
infection)
has
recently
attracted
increased
research
attention,
which
is
significantly
important
construction
libraries
diagnostic
integration.
However,
reviews
focusing
on
integrated
strategies
dye-based
diagnosis
treatment
wide
application
are
extremely
rare.
this
review,
first,
brief
history
development
dyes,
transformation
from
bioimaging
therapy,
concept
optics-based
integration
its
significance
human
presented.
Next,
systematic
review
several
excellent
rhodamine-based
well
treatment,
Finally,
challenges
practical
future
outlook
clinical
translation
also
discussed.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(33)
Published: April 21, 2023
Nanozymes,
nanomaterials
with
enzyme-mimicking
activity,
have
attracted
tremendous
interest
in
recent
years
owing
to
their
ability
replace
natural
enzymes
various
biomedical
applications,
such
as
biosensing,
therapeutics,
drug
delivery,
and
bioimaging.
In
particular,
the
nanozymes
capable
of
regulating
cellular
redox
status
by
mimicking
antioxidant
mammalian
cells
are
great
therapeutic
significance
oxidative-stress-mediated
disorders.
As
distinction
physiological
oxidative
stress
(oxidative
eustress)
pathological
distress)
occurs
at
a
fine
borderline,
it
is
challenge
design
that
can
differentially
sense
two
extremes
cells,
tissues
organs
mediate
appropriate
chemical
reactions.
this
Review,
we
summarize
advances
development
redox-active
applications.
We
primarily
highlight
prooxidant
disease
model
systems,
cancer,
neurodegeneration,
cardiovascular
diseases.
The
future
perspectives
emerging
area
research
challenges
associated
applications
described.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(3), P. 753 - 753
Published: March 20, 2023
Nitric
oxide,
a
ubiquitous
molecule
found
throughout
the
natural
world,
is
key
implicated
in
many
central
and
benefic
molecular
pathways
has
well-established
role
function
of
nervous
system,
as
numerous
studies
have
previously
shown.
Dysregulation
its
metabolism,
mainly
upregulation
nitric
oxide
production,
been
proposed
trigger
and/or
aggravator
for
neurological
affections.
Increasing
evidence
supports
implication
this
prevalent
neurodegenerative
diseases,
such
Parkinson’s
disease,
Alzheimer’s
or
amyotrophic
lateral
sclerosis.
The
mechanisms
neurotoxicity
center
around
increased
quantities
that
are
produced
brain,
their
cause,
and,
most
importantly,
pathological
metabolic
cascades
created.
These
lead
to
formation
neuronal
toxic
substances
impair
neurons’
structure
on
multiple
levels.
purpose
review
present
main
causes
well
important
pathophysiological
triggered
by
could
help
explain
part
complex
picture
diseases
develop
targeted
therapies.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15200 - 15200
Published: Oct. 15, 2023
Nitric
oxide
(NO)
plays
an
important
and
diverse
signalling
role
in
the
cardiovascular
system,
contributing
to
regulation
of
vascular
tone,
endothelial
function,
myocardial
haemostasis,
thrombosis,
amongst
many
other
roles.
NO
is
synthesised
through
nitric
synthase
(NOS)-dependent
L-arginine-NO
pathway,
as
well
nitrate-nitrite-NO
pathway.
The
three
isoforms
NOS,
namely
neuronal
(NOS1),
inducible
(NOS2),
(NOS3),
have
different
localisation
functions
human
body,
are
consequently
thought
differing
pathophysiological
Furthermore,
we
continue
develop
a
deepened
understanding
roles
NOS
disease,
possibility
therapeutically
modulating
activity
has
emerged.
Indeed,
impaired
(or
dysfunctional),
overactive
dysregulated)
attractive
therapeutic
targets
disease.
This
review
aims
describe
recent
advances
elucidating
physiological
within
mechanisms
dysfunctional
dysregulated
We
then
discuss
modulation
target
development
novel
therapeutics.
Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
240(3)
Published: Jan. 25, 2024
Abstract
Our
aim
is
to
present
an
updated
overview
of
the
erythrocyte
metabolism
highlighting
its
richness
and
complexity.
We
have
manually
collected
connected
available
biochemical
pathways
integrated
them
into
a
functional
metabolic
map.
The
focus
this
map
on
main
consisting
glycolysis,
pentose
phosphate
pathway,
redox
metabolism,
oxygen
purine/nucleoside
membrane
transport.
Other
recently
emerging
are
also
curated,
like
methionine
salvage
glyoxalase
system,
carnitine
lands
cycle,
as
well
remnants
carboxylic
acid
metabolism.
An
additional
goal
review
dynamics
providing
key
numbers
used
perform
basic
quantitative
analyses.
By
synthesizing
experimental
computational
data,
we
conclude
that
foundations
Additionally,
can
sense
levels
oxidative
stress
adjusting
mechanics,
function.
In
conclusion,
fine‐tuning
controls
one
most
important
biological
processes,
is,
loading,
transport,
delivery.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
