Gas Therapy: Generating, Delivery, and Biomedical Applications

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

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Inorganic nitrate benefits contrast-induced nephropathy after coronary angiography for acute coronary syndromes: the NITRATE-CIN trial

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(18), P. 1647 - 1658

Published: March 21, 2024

Contrast-induced nephropathy (CIN), also known as contrast-associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity and mortality following coronary angiographic procedures in high-risk patients remains unmet need. In pre-clinical studies inorganic nitrate, which is chemically reduced vivo to nitric oxide, renoprotective but this observation yet be translated clinically. study, efficacy nitrate prevention CIN presenting with syndromes (ACS) reported.

Language: Английский

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Structurally Oriented Carbon Dots as ROS Nanomodulators for Dynamic Chronic Inflammation and Infection Elimination

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22055 - 22070

Published: Aug. 8, 2024

The selective elimination of cytotoxic ROS while retaining essential ones is pivotal in the management chronic inflammation. Co-occurring bacterial infection further complicates conditions, necessitating precision and an efficacious treatment strategy. Herein, dynamic nanomodulators are rationally constructed through regulating surface states herbal carbon dots (CDs) for on-demand inflammation or elimination. phenolic OH containing CDs derived from honeysuckle (HOCD) dandelion (DACD) demonstrated appropriate redox potentials, ensuring their ability to scavenge such as ·OH ONOO–, invalidity toward O2·–, H2O2, NO. This enables efficient without affecting signal pathways. C–N/C═N taxus leaves (TACD) DACD renders them with suitable band structures, facilitating absorption red region generation O2·– upon light irradiation sterilization. Specifically, facilely prepared demonstrates fascinating modulating ability, making it highly addressing concurrent infection, diabetic wound infection. regulation strategy facilitates realization precise minimal side effects, holding immense potential clinical practice.

Language: Английский

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Advances in the Regulation of Inflammatory Mediators in Nitric Oxide Synthase: Implications for Disease Modulation and Therapeutic Approaches

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1204 - 1204

Published: Jan. 30, 2025

Nitric oxide synthases (NOS) are crucial enzymes responsible for the production of nitric (NO), a signaling molecule with essential roles in vascular regulation, immune defense, and neurotransmission. The three NOS isoforms, endothelial (eNOS), neuronal (nNOS), inducible (iNOS), tightly regulated by inflammatory mediators cellular pathways. While physiological NO is vital maintaining homeostasis, dysregulated activity contributes to pathogenesis numerous diseases, including cardiovascular disorders, neurodegenerative conditions, cancer. Recent advances understanding molecular mechanisms regulation have unveiled novel therapeutic opportunities, isoform-specific modulators, upstream pathways, nanotechnology-enhanced delivery systems. This review highlights these advancements, offering insights into how targeting its regulatory network can enable precise effective strategies managing inflammation-driven pathologies.

Language: Английский

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Aggregation-induced emission-based fluorescent probes for cellular microenvironment detection

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 274, P. 117130 - 117130

Published: Jan. 5, 2025

Language: Английский

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Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 4984 - 4984

Published: Nov. 23, 2022

Long COVID, a condition characterized by symptom and/or sign persistence following an acute COVID-19 episode, is associated with reduced physical performance and endothelial dysfunction. Supplementation of l-arginine may improve muscle function stimulating nitric oxide synthesis. A single-blind randomized, placebo-controlled trial was conducted in adults aged between 20 60 years persistent fatigue attending post-acute outpatient clinic. Participants were randomized 1:1 to receive twice-daily orally either combination 1.66 g plus 500 mg liposomal vitamin C or placebo for 28 days. The primary outcome the distance walked on 6 min walk test. Secondary outcomes handgrip strength, flow-mediated dilation, persistence. Fifty participants placebo. Forty-six (median (interquartile range) age 51 (14), 30 [65%] women), 23 per group, received intervention which they allocated completed study. At days, increased (+30 (40.5) m; placebo: +0 (75) m, p = 0.001) induced greater improvement strength (+3.4 (7.5) kg) compared (+1 (6.6) kg, 0.03). dilation active group than (14.3% (7.3) vs. 9.4% (5.8), reported two (8.7%) 21 (80.1%; < 0.0001). supplementation improved walking performance, function, long COVID. This supplement may, therefore, be considered restore relieve symptoms this patient population.

Language: Английский

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Magnesium and the Brain: A Focus on Neuroinflammation and Neurodegeneration

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 223 - 223

Published: Dec. 23, 2022

Magnesium (Mg) is involved in the regulation of metabolism and maintenance homeostasis all tissues, including brain, where it harmonizes nerve signal transmission preserves integrity blood–brain barrier. Mg deficiency contributes to systemic low-grade inflammation, common denominator most diseases. In particular, neuroinflammation hallmark neurodegenerative disorders. Starting from a rapid overview on role magnesium this narrative review provides evidences linking derangement balance with multiple sclerosis, Alzheimer’s, Parkinson’s

Language: Английский

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A Multifunctional Nanozyme with NADH Dehydrogenase‐Like Activity and Nitric Oxide Release under Near‐Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: June 16, 2023

In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need develop new antibacterial agents effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH NAD+ , thus disrupting redox balance in bacterial cells and resulting death; meanwhile, onsite NIR light-delivered NO eradicates methicillin-resistant Staphylococcus aureus (MRSA) biofilms, promotes wound healing; furthermore, shows excellent photothermal effect that enhances efficacy as well. With combination dehydrogenase activity, therapy, gas displays both vitro vivo MRSA infection biofilm eradication, which provides therapeutic modality treating inflammatory wounds.

Language: Английский

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Apoptosis and eryptosis: similarities and differences

APOPTOSIS, Journal Year: 2023, Volume and Issue: 29(3-4), P. 482 - 502

Published: Nov. 30, 2023

Language: Английский

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Hyperlipidemia and Cardiovascular Risk in Children and Adolescents

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 809 - 809

Published: March 7, 2023

Atherosclerotic cardiovascular disease (ASCVD) represents the major cause of morbidity and mortality worldwide. The onset atherosclerosis process occurs during childhood adolescence, subsequently leading to as young adults. Several risk factors can be identified in children adolescents; however, hyperlipidemia, conjunction with global obesity epidemic, has emerged most prevalent, playing a key role development ASCVD. Therefore, screening for hyperlipidemia is strongly recommended detect high-risk presenting these disorders, patients deserve more intensive investigation intervention. Treatment should initiated early possible order reduce future In this review, we will discuss lipid metabolism focusing on correlations therapeutic management or almost completely avoid

Language: Английский

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