Emerging therapies in cancer metabolism

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(8), P. 1283 - 1303

Published: Aug. 1, 2023

Language: Английский

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Cold and hot tumors: from molecular mechanisms to targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 18, 2024

Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.

Language: Английский

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Metabolic regulation of the hallmarks of stem cell biology

Cell stem cell, Journal Year: 2024, Volume and Issue: 31(2), P. 161 - 180

Published: Feb. 1, 2024

Language: Английский

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Molecular and cellular mechanisms underlying the failure of mitochondrial metabolism drugs in cancer clinical trials

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(3)

Published: Feb. 1, 2024

Language: Английский

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Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(5), P. 1066 - 1079

Published: May 1, 2024

The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD

Language: Английский

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Lactate and lactylation in cancer

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 11, 2025

Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation fate regulation in physiological pathological settings, particularly intricate conditions such as cancer. Specifically, been demonstrated to be pivotal molding tumor microenvironment (TME) through its effects different cell populations. Within cells, impacts signaling pathways, augments shuttle process, boosts resistance oxidative stress, contributes lactylation. In various populations, interplay between immune cells governs processes differentiation, response, surveillance, treatment effectiveness. Furthermore, communication stromal/endothelial supports basal membrane (BM) remodeling, epithelial-mesenchymal transitions (EMT), metabolic reprogramming, angiogenesis, drug resistance. Focusing production transport, specifically dehydrogenase (LDH) monocarboxylate transporters (MCT), shown promise Inhibitors targeting LDH MCT act both suppressors enhancers immunotherapy, leading a synergistic therapeutic effect when combined with immunotherapy. The review underscores importance progression provides valuable perspectives potential approaches that target vulnerability metabolism, highlighting Heel Achilles for cancer treatment.

Language: Английский

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The Warburg Effect Explained: Integration of Enhanced Glycolysis with Heterogeneous Mitochondria to Promote Cancer Cell Proliferation

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15787 - 15787

Published: Oct. 31, 2023

The Warburg effect is the long-standing riddle of cancer biology. How does aerobic glycolysis, inefficient in producing ATP, confer a growth advantage to cells? A new evaluation large set literature findings covering and its yeast counterpart, Crabtree effect, led an innovative working hypothesis presented here. It holds that enhanced glycolysis partially inactivates oxidative phosphorylation induce functional rewiring TCA cycle enzymes generate non-canonical metabolic pathways sustain faster rates. has been structured by constructing two maps, one for metabolism other effect. New lines investigation, suggested these are discussed as instrumental leading toward better understanding biology order allow development more efficient metabolism-targeted anticancer drugs.

Language: Английский

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The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(11)

Published: Nov. 11, 2023

Abstract Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily attributed to persistent infection of high-risk Human papillomavirus (HPV). Despite extensive research, pathogenesis CC remains unclear. N6-methyladenosine (m6A) methylation, most prevalent form epigenetic modification in RNA, intricately linked cell proliferation, metastasis, metabolism, and therapeutic resistance within tumor microenvironment (TME) CC. The involvement writer, reader, eraser m6A impacts advancement tumors through regulation RNA stability, nuclear export, translation efficiency, degradation. Here, we discuss biogenesis m6A, atypical expressions regulators, mechanisms molecular interactions, their functions Furthermore, elucidate non-coding RNA. In context precision medicine, advancements genomics, proteomics, high-throughput sequencing technologies, summarize application clinical diagnosis treatment Additionally, new perspectives on detection methods, immune regulation, nano-drug development are presented, which lay foundation for further research provide ideas

Language: Английский

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NIR-II imaging-guided precise photodynamic therapy for augmenting tumor-starvation therapy by glucose metabolism reprogramming interference

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(9), P. 1263 - 1274

Published: Feb. 9, 2024

Language: Английский

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Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: May 22, 2024

Abstract Radiotherapy is one of the mainstream approaches for cancer treatment, although clinical outcomes are limited due to radioresistance tumor cells. Hypoxia and metabolic reprogramming hallmarks initiation progression closely linked radioresistance. Inside a tumor, rate angiogenesis lags behind cell proliferation, underdevelopment abnormal functions blood vessels in some loci result oxygen deficiency cells, i.e., hypoxia. This prevents radiation from effectively eliminating hypoxic Cancer cells switch glycolysis as main source energy, phenomenon known Warburg effect, sustain their rapid proliferation rates. Therefore, pathways involved hypoxia-induced promising intervention targets treatment. In this review, we discussed mechanisms underlying hypoxia detail, including DNA repair, role stem oxidative stress relief, autophagy regulation, immune escape. addition, proposed existence feedback loop between energy hypoxia, which associated with development exacerbation tumors. Simultaneous blockade other tumor-specific can be an effective approach overcome comprehensive overview provides new insights into radiosensitivity progression.

Language: Английский

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